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| 1 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 2 | Influence of Education on Subcortical Hyperintensities and Global Cognitive Status in Vascular Dementia显示文摘 | Lane EM Paul RH Moser DJ Fletcher TD Cohen RA | | 0，，： | 1 |
| 3 | Influence of education onsubcortical hyperintensities and global cognitive status in vascul indementia 显示文摘 | Lane EM Paul RH Moser DJ | 2011 | J Int Neumpsychol Soc2011，17，3： | 1 |
| 4 | Anti-biofilm efficacy of ni-tric oxide-releasing silica nanoparticles 显示文摘 | Hetriek EM Shin JH Paul HS e( al | 2009 | Biomatefials2009，30，： | 1 |
| 5 | Choosing the ideal nephrostomy tube显示文摘 | Paul EM Marcovich R Lee BR | 2003 | BJU Int2003，92，7： | 1 |
| 6 | Osteosclerotic prostate cancer metastsis to murine bone are enhanced with increased bone formation显示文摘 | Gomes RR Jr Buttke P Paul EM | 2009 | Clin Exp Metastasis2009，26，7： | 1 |
| 7 | Enhanced osteoclastic resorp- tion and responsiveness to mechanical load in gap junction deficient bone 显示文摘 | Zhang Y Paul EM Sathyendra V | 2011 | PLoS One2011，6，23： | 1 |
| 8 | choosing the ideal nephrostomy tube显示文摘 | Paul EM Marcovich R Lee BR | 2003 | BJU Int2003，92，： | 1 |
| 9 | Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis 显示文摘 | Paul EM Gary PZ | 2004 | BMJ2004，328，7453： | 1 |
| 10 | Short-term outcome analysis of total pelvic reconstruction with mesh:the vaginal approach显示文摘 | Shan DK Paul EM Rastinehad AR | 2004 | J Urol2004，171，1： | 1 |
| 11 | Malignant esophageal and esophagorespiratory fistula:palliation with polyethylene covered Z-stents显示文摘 | Richard R Katherine EM Paul CL | 1997 | Radiology1997，202，： | 1 |
| 12 | Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing显示文摘 | Loiselle AE Paul EM Lewis GS | 2013 | J Orthop Res2013，311，： | 1 |
| 13 | Stimulation of tumor cell growth by vasoactive intestinal peptide 显示文摘 | Scholar EM Paul S | 1991 | Cancer1991，67，6： | 1 |
| 14 | Can paronyehiacause are- motenecrotizing soft tissue infection 显示文摘 | Julian EL Anne EM Paul L | 2011 | J Emerg Med2011，40，1： | 1 |
| 15 | Mutations in the Gene Encoding IFT Dynein Complex Component WDR34 Cause Jeune Asphyxiating Thoracic Dystrophy显示文摘 | Miriam Schmidts Julia Vodopiutz Sonia Christou-Savina Claudio R. Cortés Aideen M. McInerney-Leo Richard D. Emes Heleen H. Arts Beyhan Tüysüz Jason D’Silva Paul J. Leo Tom C. Giles Machteld M. Oud Jessica A. Harris Marije Koopmans Mhairi Marshall Nursel El | 2013 | The American Journal of Human Genetics2013，，5： | 1 |
| 16 | Choosing the ideal nephrostomy tube显示文摘 | Paul EM Marcovich R Lee BR Smith AD | 2003 | BJU Int2003，92，： | 1 |
| 17 | Meta-analysis of parenteral nutrition versus enteral nutrition in patients with actue pancreatitis 显示文摘 | PAUL EM GRAY PZ | 2004 | BMJ2004，328，7453： | 1 |
| 18 | Thyroid function in term and late preterm infants with respiratory distress in relation to se- verity of illness显示文摘 | Paul DA Mackley A Yencha EM | 2010 | Thyroid2010，20，2： | 1 |
| 19 | Osteoblast and osteocyte-spe- cific loss of Connexin43 resuhs in delayed bone formation and heal- ing during murine fracture healing 显示文摘 | Loiselle AE Paul EM Lewis GS | 2013 | J Orthop Res2013，31，1： | 1 |
| 20 | Stimulation of tumor cell growth by vasoactive intestinal peptide 显示文摘 | Scholar EM Paul S | 1991 | Cancer1991，67，4： | 1 |
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