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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 3 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 4 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 5 | Elevated CO2 and water depth regulation of methane emissions:Comparison of woody and non-woody wetland plant species显示文摘 | VANN C D PATRICK MEGONIGAL J | 2003 | Biogeochemistry2003，63，2： | 1 |
| 6 | Nitrous oxide emission from Gulf Coast wetlands 显示文摘 | Smith C J DeLaune R D Patrick W H Jr | 1983 | Geochimica et Cosmochimica Acta1983，47，10： | 1 |
| 7 | Al and Si:their speciation,distribution,and toxicity显示文摘 | Glen F Van Landeghem Marc E De Broe Patrick C D'Haese | 1998 | Clinical Biochemistry1998，31，5： | 1 |
| 8 | Chernobyl Cs-137 used to determine sediment accretion rates at selected north European coastal wetlands显示文摘 | Callaway J C Delaune R D Patrick W H | 1996 | Limnology and Oceanography1996，41，3： | 1 |
| 9 | PCB and PAH releases from power stations and waste incineration processes in the UK 显示文摘 | PATRICK H D FOAN C FIEDLER H | 2003 | Chemosphere2003，50，4： | 1 |
| 10 | Fiber grating sensors 显示文摘 | A D Kersey M A Davis H J Patrick M LeBlanc K P Koo C G Askins M A Putnam E J Friebele | 1997 | Lightwave Technology1997，15，8： | 1 |
| 11 | Power budgetingof a multiple- input Buck-Boost converter显示文摘 | Nicholas D B Patrick L C | 2005 | IEEE Transaction on Pow- er Electronics2005，20，6： | 1 |
| 12 | Blackbody emissivity considerations for radiometric calibration of the MODIS airborne simulation (MAS) thermal channels显示文摘 | Christopher C Moeller Patrick S Grant Dan D Laporte | 1996 | SPIE1996，2820，： | 1 |
| 13 | The use of the analysis of variance to assess the influence of mixing during composting显示文摘 | Patrick D S Benedita C Walker L P | 2000 | Process Biochemistry2000，35，： | 1 |
| 14 | Chernobyl Cs-137 used to determine sediment accretion rate at selected north European coastal wetlands 显示文摘 | CALLAWAY J C DELAUNE R D PATRICK W H | 1996 | Limnol Oceanogr1996，41，3： | 1 |
| 15 | The reduction of silica carbon and silicon carbide 显示文摘 | Patrick D M Lee J G Ivan B C | 1979 | J Am Ceram Soc1979，62，34： | 1 |
| 16 | Nanoparticles in cancer therapy and diagnosis显示文摘 | IRENE B CATHERINE D PATRICK C | 2002 | Adv Drug Deliv Rev2002，54，5： | 1 |
| 17 | Nitrous ox- ide emission from Gulf Coast wetlands显示文摘 | SMITH C J DELAUNE R D PATRICK W H | 1983 | GeochimicaetCosmo chimicaActa1983，47，10： | 1 |
| 18 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
| 19 | Permeability ad channel-mediated transport of boric acid across membrane vesicles isolated from squash roots 显示文摘 | CHRISTOS D MAARTEN J C PATRICK H B | 2000 | Plant Physiol2000，124，： | 1 |
| 20 | Persistent abnormal left ventricular systolic torsion in dilated cardiomyopathy after partial left ventriculectomy显示文摘 | Randolph M Setser Jane M Kasper Michael L Lieber Randall C Starling Patrick M McCarthy Richard D White | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，： | 1 |
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