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923篇 您的检索式：作者名="Parsons C"

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	题名	作者	年代	出处	被引量
1	Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China.	Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang	2022	Stroke & Vascular Neurology2022，7，1：	2
2	Temperature dependence of slow adsorption and desorption kinetics of organic compounds in sediments显示文摘	Cornelissen C van Noort P C M Parsons J R	1997	Environ Sci Techuol1997，31，：	1
3	Phytase, Citric Acid and 1α- Hydroxycholecalciferol Improve Phytate Phosphorus Utilization in Chicks Feed Corn-soybean Meal Diet 显示文摘	Snow J Baker D H Parsons C M	2004	Pouh Sci2004，83，：	1
4	Childhood predictors of adult obesity:a systematic review显示文摘	Parsons T J Power C Logan S	1999	Int J Obes Relat Metab Disord1999，23，8：	1
5	Biotites as indicators of fluorine fugacities in late stage magmatic fluids: the Gardar province of south Greenland 显示文摘	Finch A A Parsons I Mingard S C	1995	J Petrol1995，36，：	1
6	Development and in vitro evaluation of sustained release poloxamer 407 ( P407 ) gel formulations of ceftiofur 显示文摘	Zhang L Parsons DL Navarre C	2002	J Control Release2002，85，：	1
7	A randomised pilot trial of ' locking plate' fixation versus intramedullary nailing for extra-articular fractures of the distal tibia显示文摘	Mauffrey C McGuinness K Parsons N		0，，：	1
8	Visual distortion of a limb modulates the pain and swelling evoked by movement显示文摘	Moseley GL Parsons TJ Spence C	2008	Curr Biol2008，18，22：	1
9	Estimating the probability of identity in a random dog population using 15 highly polymorphic canine STR markers 显示文摘	Eichmann C Berger B Steinlechner M Parson W	2005	Forensic Science International2005，151，1：	1
10	A second conserved GAF domain cysteine is required for the blue/green photoreversibility of cy- anobacteriochrome TIr0924 from Thermosynecho- coccus elongates 显示文摘	Rockwell N C Njuguna S L Roberts L Castillo E Parson V L Dwojak S Lagarias J C Spiller S C	2008	Biochemistry2008，47，：	1
11	Effect of variable speed wind turbine generator on stability of a weak grid显示文摘	MULJADI E BUTTERFIELD C P PARSONS B	2007	IEEE Transactions on Energy Conversion2007，22，1：	1
12	A proposal for standardization in forensic canine DNA typing: allele nomenclature of six canine-specific STR loci 显示文摘	Hellmann AP Rohleder U Eichmann C Pfeiffer I Parson W Schleenbecker U	2006	Journal of Forensic Science2006，51，：	1
13	Fetal and early life growth and body mass index from birth to early adulthood in1958British co-hort:Longitudinal study显示文摘	PARSONS TJ POWER C MANOR O	2001	BMJ2001，323，7325：	1
14	Effects of model orientation and wall heating condition on local heat transfer in a rotating two-pass square channel with 90° rib turbulators显示文摘	Parsons J A Han J C Zhang Y M	1995	International Journal of Heat and Mass Transfer1995，38，：	1
15	InSAR Observations of Low Slip Rates on the Major Faults of Western Tibet显示文摘	WRIGHT T J PARSONS B ENGLAND P C	2004	Science2004，305，：	1
16	Middle cerebral artery occlusion produces secondary,remote impairment in hippocampal plasticity of rats-involvement of N-methyl-D-aspartate receptors显示文摘	Sopala M Frankiewicz T Parsons C	2000	Neuroscience Letters2000，281，：	1
17	Effect of variable speed wind turbine generator on stability of a weak grid显示文摘	MULJADI E BUTTERFIELD C P PARSONS B	2007	IEEE Transactions on Energy Conversion2007，22，1：	1
18	Nutritional evaluation of lectin-free soybeans for poultry 显示文摘	Douglas M W Parsons C M Hymowitz T	1999	Pouh Sci1999，78，：	1
19	Systemic infusion of angiotensin II exacerbate liver fibrosis in bile duet ligation rata显示文摘	Bataller R Gabele E Parsons C J	2005	Hepatology2005，41，5：	1
20	CdZnTe and CdTe detector arrays for hard X-ray and gamma-ray astronomy 显示文摘	Stahle C M Parker B H Parsons A M	1999	Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment1999，436，12：	1

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