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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | PCR amplifica- tion of the Irish potato famine pathogen from historic specimens 显示文摘 | RISTAINO J B GROVES C T PARRA G R | 2001 | Nature2001，411，6838： | 1 |
| 3 | Bioleaching of refractory gold concentrates at high pulp densities in a nonconventional rotating-drum reactor 显示文摘 | HERRERA M N ESCOBAR B PARRA N GONZALEZ C VARGAS T | 1998 | Minerals and Metallurgy Processing1998，15，： | 1 |
| 4 | Oxidative stress by Helicobacter pylofi causes apoptosis through mitochondrial pathway in gastric epithelial cells显示文摘 | Calvino - FernOndez M Benito - Martinez S Parra - Cid T | 2008 | Apoptosis2008，13，10： | 1 |
| 5 | Influence of vegetable shortening and emulsifiers on the unfrozen water content and textural properties of frozen French bread dough显示文摘 | MATUDA T G PARRA D F LUGAO A B | 2005 | Lebensmittel Wissenschaft und Technologie2005，38，： | 1 |
| 6 | PCR amplification of the Irish potato famine pathogen from historic specimens 显示文摘 | Ristanio J B Groves C T Parra G R | 2001 | Nature2001，411，： | 1 |
| 7 | Proteolytic activity of lactobacilli in a model goats’milk curd system显示文摘 | Parra L Requena T Casal V | 1996 | Lett Appl Microbiol1996，，： | 1 |
| 8 | Extinction of premixed methane-air flames by water mist显示文摘 | Parra T | 2004 | Fire Safety Journal2004，39，7： | 1 |
| 9 | Mechanical and microstructural investigation of friction spot welded AA6181-T4 aluminum alloy显示文摘 | ROSENDO T PARRA B TIER M A D | | 0，，： | 1 |
| 10 | The mycobacterial heparin-bind- ing hemagglutinin is a protective antigen in the mouse aerosol chall- enge model of tuberculosis显示文摘 | Parra M Pickett T Delogu G | 2004 | Infect Immun2004，72，12： | 1 |
| 11 | Mechanical and micro- structual investigation of friction spot welded AA6181-T4 alumin- ium alloy显示文摘 | Rosenda T Parra B Tier M A D | 2011 | Materials & Dsign2011，32，3： | 1 |
| 12 | PCR amplifica- tion of the Irish potato famine pathogen from historic specimens 显示文摘 | Ristaino J B Groves C T Parra G R | 2001 | Nature2001，411，6838： | 1 |
| 13 | Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes 显示文摘 | Parra M Mahmoudi T Verdin E | 2007 | Genes Dev2007，21，6： | 1 |
| 14 | Influence of vegetable shortening and emulsifiers on the unfrozen water content and textural properties of frozen French bread dough显示文摘 | MATUDA T G PARRA D F LUGAO A B | 2005 | Lebensmittel Wissenschaft und Technologie2005，38，： | 1 |
| 15 | The electrical leak location method for geomembrane liners显示文摘 | Glenn T Darilek Jorge O Parra | 1989 | Journal of Hazardous Materials1989，21，： | 1 |
| 16 | FK506 in the maturation of dendritic cells显示文摘 | Cos J Villalba T Parra R Gallardo D Bilbao I Margarit C | 2002 | Haematologica2002，87，7： | 1 |
| 17 | Proteolytic activity of lactobacilliin a model goats'milk curd system显示文摘 | PARRA L REQUENA T CASAL V | 1996 | Lett Appl Microbiol1996，23，6： | 1 |
| 18 | Numerical and experimental analysis of different ventilation systems in deep mines 显示文摘 | PARRA M T VILLAFRUELA J M CASTRO F | 2006 | Building and Environment2006，41，： | 1 |
| 19 | Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease显示文摘 | Izquierdo JL Almonacid C Parra T | 2006 | Arch Bronconeumol2006，42，7： | 1 |
| 20 | The mycobacterial heparin-binding hemagglutinin is a protective antigen in themouse aerosol challenge model of tuberculosis显示文摘 | Parra M Picket T Delogu G | 2004 | Infect Immun2004，72，12： | 1 |
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