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| 1 | Surgical vs percutaneous radiofrequency ablation for hepatocellular carcinoma in dangerous locations显示文摘AIM:To compare the long-term outcome of percutaneous vs surgical radiofrequency ablation(RFA) for hepatocellular carcinoma(HCC) in dangerous locations.METHODS:One hundred and sixty-two patients with HCC in dangerous locations treated with percutaneous or surgical RFA were enrolled in this study.The patients were divided into percutaneous RFA group and surgical RFA group.After the patients were regularly followed up for a long time,their curative rate,hospital stay time,postoperative complications and 5-year local tumor progression were compared and analyzed.RESULTS:No significant difference was observed in curative rate between the two groups(91.3% vs 96.8%,P = 0.841).The hospital stay time was longer and more analgesics were required while the incidence of bile duct injury and RFA-related hemorrhage was lower in surgical RFA group than in percutaneous RFA group(P < 0.05).The local progression rate of HCC in dangerous locations was significantly lower in surgical RFA group than in percutaneous RFA group(P = 0.05).The relative risk of local tumor progression was 14.315 in percutaneous RFA group.CONCLUSION:The incidence of severe postoperative complications and local tumor progression is lower after surgical RFA than after percutaneous RFA. | Ji-Wei Huang Roberto Hernandez-Alejandro Kristopher P Croome Lu-Nan Yan Hong Wu Zhe-Yu Chen Pankaj Prasoon Yong Zeng | 2011 | World Journal of Gastroenterology2011，17，1： | 14 |
| 2 | Laparoscopic fenestration vs open fenestration in patients with congenital hepatic cysts: A meta-analysis显示文摘AIM: To determine whether the outcomes of laparoscopic fenestration (LF) were superior to open fenestration (OF) for congenital liver cysts.METHODS: Comparative studies published between January 1991 and May 2010 on Medline (Ovid),Emsco,PubMed,Science Direct;Cochrane Reviews;CNKI;Chinese Biomedical Database,VIP and other electronic databases were searched.Randomized controlled trials (RCTs) and retrospective case-control studies on the management of congenital hepatic cysts were collected according to the pre-determined eligibility criteria to establish a literature database.Retrieval was ended in May 2010.Meta-analysis was performed using RevMan 5.0 software (Cochrane library).RESULTS: Nine retrospective case-control studies involving 657 patients,comparing LF with OF were included for the final pooled analysis.The meta-analysis results showed less operative time [mean difference (MD): -28.76,95% CI: -31.03 to 26.49,P < 0.00001];shorter hospital stay (MD: -3.35,95% CI: -4.46 to -2.24,P < 0.00001);less intraoperative blood loss (MD: -40.18,95% CI: -52.54 to -27.82,P < 0.00001);earlier return to regular diet (MD: -29.19,95% CI: -30.65 to -27.72,P < 0.00001) and activities after operation (MD: -21.85,95% CI: -31.18 to -12.51,P < 0.0001) in LF group;there was no significant difference between the two groups in postoperative complications (odds ratio: 0.99,95% CI: 0.41 to 2.38,P = 0.98) and cysts recurrence rates.CONCLUSION: The short-term outcomes of LF for patients with congenital hepatic cysts were superior to open approach,but its long-term outcomes should be verified by further RCTs and extended follow-up. | Prasoon Pankaj | 2011 | World Journal of Gastroenterology2011，17，28： | 14 |
| 3 | Immunotherapy for hepatocellular carcinoma: From basic research to clinical use显示文摘Hepatocellular carcinoma(HCC) is a common cancer worldwide with a poor prognosis. Few strategies have been proven efficient in HCC treatment, particularly for those patients not indicated for curative resection or transplantation. Immunotherapy has been developed for decades for cancer control and is attaining more attention as a result of encouraging outcomes of new strategies such as chimeric antigen receptor T cells and immune checkpoint blockade. Right at the front of the new era of immunotherapy, we review the immunotherapy in HCC treatment, from basic research to clinical trials, covering anything from immunomodulators, tumor vaccines and adoptive immunotherapy. The mechanisms, efficacy and safety as well as the approach particulars are unveiled to assist readers to gain a concise but extensive understanding of immunotherapy of HCC. | Yu-Peng Hong Zi-Duo Li Pankaj Prasoon Qi Zhang | 2015 | World Journal of Hepatology2015，7，7： | 6 |
| 4 | Synchronous intraoperative radiofrequency ablation for multiple liver metastasis and resection of giant solid pseudopapillary tumors of the pancreas显示文摘 | LI Jia-xin WU Hong HUANG Ji-wei Pankaj Prasoon ZENG Yong | 2012 | Chinese Medical Journal2012，，9： | 5 |
| 5 | Hemi-portocaval shunt: A simple salvage maneuver for small-for-size graft during living donor liver transplantation: a case report显示文摘自从在最后几十年的生活施主肝移植(LDLT ) 的快扩大, small-for-size 症候群(SFSS ) 作为一个坚韧的问题出现了。此处, LDLT 的第一个案例在中国的大陆联合了 hemi-portocaval 分流被报导。门静脉的 overperfusion 很好被调制,接受者太平无事地恢复了。LDLT 联合了 hemi-portocaval 分流是为在 LDLT 阻止 SFSS 的一个可行过程。 | HUANG Ji-wei YAN Lu-nan CHEN Zhe-yu WU Hong LU Qiang XU Ying-long Pankaj Prasoon ZENG Yong | 2011 | Chinese Medical Journal2011，，14： | 4 |
| 6 | Laparoscopy Versus Open Distal Gastrectomy for Advanced Gastric Cancer: A Systematic Review and Meta-Analysis显示文摘 | Jianguo Qiu Prasoon Pankaj Hui Jiang Yong Zeng Hong Wu | 2013 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2013，，1： | 3 |
| 7 | Laparoscopy Versus Open Distal Gastrectomy for Advanced Gastric Cancer: A Systematic Review and Meta-Analysis显示文摘 | Jianguo Qiu Prasoon Pankaj Hui Jiang Yong Zeng Hong Wu | 2013 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2013，，1： | 2 |
| 8 | ''Sandwich'' treatment for diospyrobezoar intestinal obstruction: A case report显示文摘Intestinal obstruction is a common clinical entity encountered in surgical practice.The objective of this report is to corroborate an atypical scenario of intestinal obstruction in a Chinese patient and to focus on the diagnosis and treatment.A 27-year-old male presented with a history of gastric pain combined with nausea and abdominal distension that had been present for 5 d.The presence of a foreign body was detected by computed tomography and observed as an abnormal density within the stomach.A diospyrobezoar was revealed during gastroscopy,the extraction of which was preventeddue to its size and firmness.An endoscopic holmium laser joined with a snare was used to fragment the obstruction,which was followed by management with a conservative'sandwich'treatment strategy involving intestinal decompression with an ileus tube and Coca-Cola lavage between endoscopic lithotripsy fragmentation procedures.This strategy resulted in the successful removal of the diospyrobezoar along with multiple small bowel obstructions.The patient was discharged after abatement of symptoms.The case presented here demonstrates the implementation of a conservative,yet successful,treatment as an alternative to conventional surgical removal of intestinal obstructions. | Yi-Xiong Zheng Pankaj Prasoon Yan Chen Liang Hu Li Chen | 2014 | World Journal of Gastroenterology2014，20，48： | 1 |
| 9 | Laparoscopy Versus Open Distal Gastrectomy for Advanced Gastric Cancer: A Systematic Review and Meta-Analysis显示文摘 | Jianguo Qiu Prasoon Pankaj Hui Jiang Yong Zeng Hong Wu | 2013 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2013，，1： | 1 |
| 10 | Risk factors for incomplete polyp resection during colonoscopy显示文摘Colonoscopic polypectomy is extremely effective in protecting against colorectal cancers,and recognition of adenomas by colonoscopy is of paramount importance in preventing colorectal cancer(CRC)and CRC-associated mortality.Incomplete polyp resection(IPR)occurs routinely in medical practice following polypectomy.We conducted a comprehensive literature search to identify studies that reported on the potential risk factors for IPR using MEDLINE,EMBASE,and PubMed.Publication time was limited between January 2004 and July 2021.Our search revealed assessments of the position,morphology,and histologic variation of the polypsdas well as the relevant skills that may interfere with IPR.The included studies showed that colonic polyps with a diameter>20 mm and proximal in location should be dealt with cautiously.For smaller polyps,cold-snare polypectomy appeared to be the most effective method used to accomplish comprehensive polyp removal.In addition,endoscopist experience in narrow-band imaging in polyp detection were also associated with IPR.Therefore,polypectomy should be performed cautiously if the polyp growth is expected to be cancerous and situated in the proximal portion of the colon or rectum,and modalities should be standardized so as to lower the potential risk for IPR. | Weifeng Lao Pankaj Prasoon Gaoyang Cao Lian Tat Tan Sheng Dai Giridhar Hanumappa Devadasar Xuefeng Huang | 2021 | Laparoscopic, Endoscopic and Robotic Surgery2021，4，4： | 0 |
| 11 | Autologous bone marrow transplantation in decompensated liver: Systematic review and meta-analysis显示文摘AIM:To evaluate the efficacy of autologous bone marrow mononuclear cell transplantation in decompensated liver disease.METHODS:Medline,EMBASE,PubMed,Science Direct,and the Cochrane Library were searched for relevant studies.Retrospective case-control studies were included along with randomized clinical trials.Metaanalysis was performed in line with recommendations from the Cochrane Collaboration software review manager.Heterogeneity was assessed using a randomeffects model.RESULTS:Four randomized controlled trials and four retrospective studies were included.Cell transplantation increased serum albumin level by 1.96 g/L(95%CI:0.74-3.17;P = 0.002],2.55 g/L(95%CI:0.32-4.79;P= 0.03),and 3.65 g/L(95%CI:0.76-6.54;P = 0.01)after 1,3,and 6 mo,respectively.Patients who had undergone cell transplantation also had a lower level of total bilirubin[mean difference(MD):-1.37 mg/dL;95%CI:-2.68-(-0.06);P = 0.04]after 6 mo.This decreased after 1 year when compared to standard treatment(MD:-1.26;95%CI:-2.48-(-0.03);P =0.04].A temporary decrease in alanine transaminase and aspartate transaminase were significant in the cell transplantation group.However,after 6 mo treatment,patients who had undergone cell transplantation had a slightly longer prothrombin time(MD:5.66 s,95%CI:0.04-11.28;P = 0.05).Changes in the model for endstage liver disease score and Child-Pugh score were not statistically significant.CONCLUSION:Autologous bone marrow transplantation showed some benefits in patients with decompensated liver disease.However,further studies are still needed to verify its role in clinical treatment for end-stage liver disease. | Prasoon Pankaj Qi Zhang Xue-Li Bai Ting-Bo Liang | 2015 | World Journal of Gastroenterology2015，21，28： | 0 |
| 12 | Esophago-gastro-duodenoscopy could be an important tool in the diagnostic dilemma inherent in perforated peptic ulcer: A case report显示文摘Acute abdomen is a common and sometimes dramatic clinical condition,which can be fatal if diagnosis is not made in time.Perforated peptic ulcer is a cause of an acute abdomen,which can be diagnosed by imaging investigations.However,erect chest X-ray and CT scan may not always establish the diagnosis.Herein we report a case of a patient with acute abdomen,where radiological imaging and CT scan were not able to provide a clear diagnosis.The patient was diagnosed with perforated peptic ulcer by esophago-gastro-duodenoscopy,and underwent laparotomy to repair the anterior wall duodenal perforation with an omental patch.Early endoscopic evaluation seems to be an essential tool for upper gastrointestinal evaluation in acute abdomen cases with inconclusive imaging results. | Pankaj Prasoon Giridhar Hanumappa Devadasar Tun Aung Kyaw Mohd.Akthar Ansari Mulky Damodar Kamath Chean Leung Chong | 2022 | Laparoscopic, Endoscopic and Robotic Surgery2022，5，2： | 0 |
| 13 | The EORTC QLQ-C30 and QLQ-CR29 may play a complementary role to LARS score in evaluating the quality of life for patients following laparoscopic and robotic rectal cancer surgery显示文摘Objective:To analyze whether the European Organisation for Treatment and Research of Cancer(EORTC)Quality of Life Questionnaires(QLQ-C30 and QLQ-CR29)complement the low anterior resection of rectum syndrome(LARS)score in evaluating the quality of life of patients who underwent laparoscopic or robotic rectal cancer surgery.Methods:Initially,335 patients who underwent laparoscopic or robotic rectal cancer surgery were randomly selected at Sir Run Run Shaw Hospital,Zhejiang University School of Medicine from June 2013 to September 2020.All the patients took the questionnaires of LARS score,QLQ-C30 and QLQ-CR29.Totally,questionnaires filled out by 224 patients were qualified after screening.Patients were divided into three groups according to LARS score:No LARS group(score 0-20),minor LARS group(score 21-29)and major LARS group(score 30-42).The scores of QLQ-C30 as well as QLQ-CR29 among the three groups were compared.Results:Major,minor and no LARS groups had 140 cases,40 cases and 44 cases respectively.In the scales of QLQ-C30,significant differences were discovered in global quality of life,physical function,role function,emotional function,cognitive function,social function,fatigue,pain,dyspnea,sleep disturbance,constipation and diarrhea between the no and major LARS groups(p<0.05).While the differences were only found in global quality of life and diarrhea between the minor and major LARS groups(p<0.05).In QLQ-CR29,scales of urinary frequency,blood and mucus in stool,body image,flatulence,fecal incontinence,sore skin,stool frequency,embarrassment,impotence,abdominal pain,buttock pain,bloating,dry mouth,hair loss,taste,anxiety and weight,had significant differences between the no and major LARS groups(p<0.05).Only six scales,ie blood and mucus in stool,flatulence,fecal incontinence,stool frequency,embarrassment and dysuria had significant differences between the minor and major LARS groups(p<0.05).Conclusion:For patients following laparoscopic or robotic low anal sphincter preserving surgery,LARS score,QLQ-C30 and QLQ-CR29 scores are consistent in overall trends.To guide disease evaluation and individualized treatment,as well as to evaluate efficacy,we suggest getting pre-and post-operative LARS scores incorporating QLQ-C30 and QLQ-CR29 scores as a comprehensive evaluation system. | Weifeng Lao Pankaj Prasoon Yangtao Pan Yiming Lv Lian Tat Tan | 2021 | Laparoscopic, Endoscopic and Robotic Surgery2021，4，3： | 0 |
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