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| 1 | Colorectal carcinogenesis:Insights into the cell death and signal transduction pathways:A review显示文摘Colorectal carcinogenesis(CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of cancers, especially in patients 60 years of age. Inflammatory polyps are currently gaining attention in CRC, and a growing body of evidence denotes the role of inflammation in CRC. Several experimental models are being employed to investigate CRC in animals, which include the APC^(min/+) mouse model, Azoxymethane, Dimethyl hydrazine, and a combination of Dextran sodium sulphate and dimethyl hydrazine. During CRC progression, several signal transduction pathways are activated. Among the major signal transduction pathways are p53, Transforming growth factor beta, Wnt/β-catenin, Delta Notch, Hippo signalling, nuclear factor erythroid 2-related factor 2 and Kelch-like ECH-associated protein 1 pathways. These signalling pathways collaborate with cell death mechanisms, which include apoptosis, necroptosis and autophagy, to determine cell fate. Extensive research has been carried out in our laboratory to investigate these signal transduction and cell death mechanistic pathways in CRC. This review summarizes CRC pathogenesis and the related cell death and signal transduction pathways. | Ashok kumar Pandurangan Thomas Divya Kalaivani Kumar Vadivel Dineshbabu Bakthavatchalam Velavan Ganapasam Sudhandiran | 2018 | World Journal of Gastrointestinal Oncology2018，10，9： | 10 |
| 2 | Electrochemical Performance and ex situ Analysis of ZnMn2O4 Nanowires as Anode Materials for Lithium Rechargeable Batteries显示文摘一个维的 ZnMn2O4 nanowires 在李作为阳极材料被准备了并且调查可充电的电池。在宽度的大约 15 nm 和在长度的 500 nm 显示出的高度水晶的 ZnMn2O4 nanowires 大约 650 mAh 獲獥 ? 的一个高特定的能力 ? 肐? 肐? | Sung-Wook Kim Hyun-Wook Lee Pandurangan Muralidharan Dong-Hwa Seo Won-Sub Yoon Do Kyung Kim Kisuk Kang | 2011 | Nano Research2011，4，5： | 7 |
| 3 | Syzygium cumini(L.)Skeels:A review of its phytochemical constituents and traditional uses显示文摘Syzygium cumini(S.cumini)(L.) Skeels(jambolan) is one of the widely used medicinal plants in the treatment of various diseases in particular diabetes.The present review has been primed to describe the existing data on the information on botany,phytochemical constituents,traditional uses and pharmacological actions of 5.cumini(L.) Skeels(jambolan).Electronic database search was conducted with the search terms of Eugenia jambolana,S.cumini,jambolan,common plum and java plum.The plant has been viewed as an antidiabetic plant since it became commercially available several decades ago.During last four decades,numerous folk medicine and scientific reports on the antidiabetic effects of this plant have been cited in the literature.The plant is rich in compounds containing anthocyanins,glucoside,ellagic acid,isoquercetin,kaemferol and myrecetin.The seeds are claimed to contain alkaloid,jambosine,and glycoside jambolin or antimellin,which halts the diastalic conversion of starch into sugar.The vast number of literatures found in the database revealed that the extracts of different parts of jambolan showed significant pharmacological actions.We suggest that there is a need for further investigation to isolate active principles which confer the pharmacological action.Hence identification of such active compounds is useful for producing safer drugs in the treatment of various ailments including diabetes. | Muniappan Ayyanar Pandurangan Subash-Babu | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，3： | 4 |
| 4 | Investigation of anticancer potencies of newly generated Schiff base imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines显示文摘A new series of multi-heterocyclic Schiff base was constructed starting from 4'-(imidazol-1-yl[56_TD$IF])-acetophenone which was converted to its 2-bromoethanone precursor which on cyclic condensation with thiourea yielded final thiazol-2-amine intermediate(3) to be reacted with substituted aldehydes to generate final imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines(4a–4i). New Schiff base was investigated for their in vitro cytotoxic efficacies against a panel of three human cancer cell lines namely, MCF7(human breast cancer), HCT116(human colon cancer), and DU145(human prostate cancer) and one normal skin fibroblast(SF). Most of these synthetic derivatives shown important cytotoxic actions against individual carcinoma cell line collections, but weak actions against SF, which is as anticipated. Observations of SAR suggested that the difference in the characteristics of substituents attached to the Schiff base function leads to the interesting variations within pharmacological effects of resultant molecular systems. Structural analysis performed using FT-IR,~1H NMR,^(13)C NMR spectroscopy and CHN analysis for final potent anticancer Schiff base, which warrant further investigations. | Nikhil M. Parekh Bhupendra M. Mistry Muthuraman Pandurangan Surendra K. Shinde Rahul V. Patel | 2017 | Chinese Chemical Letters2017，28，3： | 2 |
| 5 | Long-term Outcomes of Patients With Autoimmune Hepatitis Managed at a Nontransplant Center显示文摘 | Barbara Hoeroldt Elaine McFarlane Asha Dube Pandurangan Basumani Mohammed Karajeh Michael J. Campbell Dermot Gleeson | 2011 | Gastroenterology2011，，7： | 2 |
| 6 | Friction stir weld failure mechanisms in aluminum-armor structures under ballistic impact loading conditions显示文摘 | GRUJICIC M PANDURANGAN B ARAKERE A YEN C F CHEESEMAN B A | 2013 | J Mat Eng and Perform2013，22，： | 1 |
| 7 | Potential targets for preven- tion of colorectal cancer: a focus on PI3K/ Akt/mTOR and Wnt pathways 显示文摘 | Pandurangan AK | 2013 | Asian Pac J Cancer Prey2013，14，4： | 1 |
| 8 | Co and Mn impregnated MCM-41: their applications to vapour phase oxidation of isopropylbenzene显示文摘 | VETRIVEL S PANDURANGAN A | 2005 | Journal of Molecular Catalysis A: Chemical2005，227，2： | 1 |
| 9 | Robust computation of aggregates in wireless sensor networks: Distributed randomized algorithms and analysis显示文摘 | Chen Jen-Yeu Pandurangan G Xu Dong-yan | 2006 | IEEE Transactions on Parallel and Distributed Systems2006，17，9： | 1 |
| 10 | A highly efficient catalyst for the esterification of acetic acid using n-butyl alcohol 显示文摘 | Jermy B R Pandurangan A | 2005 | Journal of Molecular Catalysis A : Chemical2005，237，12： | 1 |
| 11 | Synthesis, characterization and catalytic application of MCM-41mesoporous molecular sieves containing Zn and Al显示文摘 | Selvaraj M Pandurangan A Seshadri K S | 2003 | Applied Catalysis A2003，242，2： | 1 |
| 12 | Efficient synthesis of diacetal of pentacrythritol under microwave irradiation using heteropolyacid H3PW12O40显示文摘 | Rabindran JB Pandurangan A | | 0，，07： | 1 |
| 13 | Comparison of mesoporous Al-MCM-41 molecular sieves in the production of p-cymene for isopropylation of toluene显示文摘 | Selvaraj M Pandurangan A Seshadri K S | 2002 | Journal of Molecular Catalysis A: Chemical2002，186，12： | 1 |
| 14 | Musculoskeletal computational analysis of the influence of car-seat design/ adjustments on long-distance driving fatigue显示文摘 | Grujicic M Pandurangan B Xie X | 2010 | InternationalJournal of Industrial Ergonomics2010，40，3： | 1 |
| 15 | Lattice based forward-secure identity based encryption scheme with shorter ciphertext 显示文摘 | Singh K Pandurangan C Banerjee A | 2013 | dournal of Internet Services and information Security2013，3，12： | 1 |
| 16 | Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis显示文摘 | Pandurangan Ashokkumar Ganapasam Sudhandiran | 2008 | Biomedicine & Pharmacotherapy2008，，： | 1 |
| 17 | Heteropoly acid(H3P W12 040 ) supported MCM-41: An efficient solid acid catalyst for the green synthesis of xanthenedionc deriva- tives显示文摘 | Karthikeyan G Pandurangan A | 2009 | J Mol Catal A:Chem2009，311，12： | 1 |
| 18 | Fa- tigue-life computational analysis for the self-expanding endovascular nitinol stents 显示文摘 | GRUJICIC M PANDURANGAN B SNIPES J S | 2012 | J Mater Eng Perform2012，21，11： | 1 |
| 19 | Synthesis of geminal diacetates (acylals) using heterogeneous H3PWI204o sup- ported MCM - 41 molecular sieves 显示文摘 | JERMY B R PANDURANGAN A | 2008 | Catal Commun2008，9，5： | 1 |
| 20 | Vapour phase isopropylation of phenol over zinc- and iron-containing Al-MCM-41 molecular sieves显示文摘 | R Savidha A Pandurangan | 2003 | Applied Catalysis A General2003，，1： | 1 |
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