|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 2 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 3 | Clinical evaluation of xylazine with barbiturate and non - barbitturate anesthesia in dogs显示文摘 | Pathak J C Pandey S S Sukla B P | 1998 | Indian Veterinary Journal1998，75，10： | 2 |
| 4 | Solid-state fermentation for the production of Monascus pigments from jackfruit seed 显示文摘 | Babitha S Soccol C R Pandey A | 2007 | Bioresouree Technology2007，98，8： | 1 |
| 5 | Biotreatment of waste gas containing pyridine in a biofilter 显示文摘 | Pandey R A Padoley K V Mukherji S S | 2007 | Bioresource Technology2007，98，12： | 1 |
| 6 | Multilayer perceptron in damage detection of bridge structures显示文摘 | Pandey P C Barai S V | 1995 | Computers & Structures1995，54，4： | 1 |
| 7 | Influence of source and time of potassium application on potato growth, yield, economics and crisp quality 显示文摘 | Kumar P Pandey S K Singh B P | 2007 | Potato Research2007，50，： | 1 |
| 8 | Concentrations of heavy metals and aquatic macrophytes of Govind Ballabh Pant Sagar an anthropogenic lake affected by coal mining effluent显示文摘 | MISHRA V K UPADHYAY A R PANDEY S K | 2008 | Environmental Monitoring and Assessment2008，141，： | 1 |
| 9 | Experimental investiga- tion on waste heat recovery by refinery oil sludge incinera- tion using fluidised-bed technique 显示文摘 | Sankaran S Pandey S Sumathy K | 1998 | J Environ SciHealth Part A1998，33，5： | 1 |
| 10 | ExtraceUular xyla- nase production by Pleurotus species on lignocellulosic wastes under in vivo condition using novel pretreatment显示文摘 | Singh M P Pandey A K Vishwakarma S K | 2012 | Cellular and Molecu- lar Biology2012，58，1： | 1 |
| 11 | Central core myopathy with RYR1 mutation masks 5q spinal muscular atrophy显示文摘 | Pandey R Chandratre S Roberts A | | 0，，： | 1 |
| 12 | Analysis of wind regimes for energy estimation显示文摘 | Mathew S Pandey K P Kumar A V | | 0，，03： | 1 |
| 13 | Surgical con- siderations in pediatric necrotizing fasciitis 显示文摘 | Pandey A Gangopadhyay A N Sharma S P | 2009 | Indian Assoc Pediatr Surg2009，14，1： | 1 |
| 14 | Endovascular coil embolization of ruptured and unruptured posterior circulation aneurysms:review of a 10-year expemrience显示文摘 | PANDEY A S KOEBBE C ROSENWASSER R H | 2007 | Neurosurgery2007，60，4： | 1 |
| 15 | Intelligent hybrid wavelet models for short-term load forecasting显示文摘 | Pandey A S Singh D Sinha S K | 2010 | IEEE Transactions on Power Systems2010，25，3： | 1 |
| 16 | Liquid-liquid two phase flow through a horizontal T- junction显示文摘 | PANDEY S GUPTA A CHAKRABARTI D P | 2006 | Chemical Engineering Research ~ De- sign2006，84，10： | 1 |
| 17 | Dynamic model of worms with vertical transmission in computer network显示文摘 | MIISHRA B K PANDEY S K | 2011 | Applied Mathematics and Computation2011，217，21： | 1 |
| 18 | Analytical Applications of Room-Temperature Ionic Liquids:A Review of Recent Efforts显示文摘 | Pandey S | 2006 | Anal Chim Acta2006，556，： | 1 |
| 19 | Analytical applications of room-temperature ionic liquids:A reviewof recent efforts显示文摘 | PANDEY S | 2006 | Analytica Chimica Acta2006，55，6： | 1 |
| 20 | A mathematical model for peristaltic transport of micro-polar fluids 显示文摘 | Pandey S K Tripathi D | 2011 | Applied Bionics and Biomechanics2011，8，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员