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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Performance Evaluation and Design Trade-Offs for Network on Chip Interconnect Architectures显示文摘 | Pande P P Grecu C Jones M | 2005 | IEEE Trans on Computers2005，54，8： | 1 |
| 3 | Structural basis for influence of viral glycans on ligand binding by influenza hemagglutinin显示文摘 | Kasson P M Pande V S | 2008 | BiophysJ2008，95，7： | 1 |
| 4 | Yield stress of fine grained materials 显示文摘 | Masumura R A Hazzledine P M Pande C S | 1998 | Acta Metallurgica Inc1998，46，13： | 1 |
| 5 | A technique for load-shedding based on voltage stability consideration显示文摘 | Arya L D Pande V S Kothari D P | 2005 | International Journal of Electrical Power & Energy Systems2005，27，7： | 1 |
| 6 | The contribution of different fractions of fines to pulp drainage in mechanical pulps显示文摘 | Liu X A Whiting P Pande H | 2001 | Journal of Pulp and Paper Science2001，27，4： | 1 |
| 7 | Behavior problems in nephrotie syndrome 显示文摘 | MEHTA M BAGGA A PANDE P | 1995 | Indian Pediatr1995，32，12： | 1 |
| 8 | Phencyclidine biock of Ca^2+-ATPase in rat heart sarcoplasmic reticulum显示文摘 | PANDE M CAMERON J A VIG P J | 1998 | Toxicology1998，129，23： | 1 |
| 9 | Behavior problems in nephrotic syndrome 显示文摘 | Mehta M Bagga A Pande P | 1995 | Indian Pediatr1995，32，12： | 1 |
| 10 | A Technical Note on Integrated Product Quality Model Using Artificial Neural Networks显示文摘 | Suneel T S Pande S S Date P P | | 0，，： | 1 |
| 11 | Synthesis and characterization of muhiwalled carbon nanotubes-polymethyl methacrylate composites prepared by in situ polymerization method显示文摘 | Pande S Mathur R B Singh B P | 2009 | Polymer Composites2009，30，： | 1 |
| 12 | Cell cycle phase,cellular Ca2+ and development in Dictyostelium discoideum显示文摘 | Azhar M Kennady P K Pande G | | 0，，2： | 1 |
| 13 | Operations for portal hyper-tension due to extrahepatic obstruction : results and 10 year followup显示文摘 | Pande GK Reddy VM Kar P | 1987 | BMJ (Clin Res Ed)1987，295，6606： | 1 |
| 14 | Design development and testing of a solar PV pump based drip system for orchards显示文摘 | Pande P C Singh A K Ansari S | 2003 | Renewable2003，2003，28： | 1 |
| 15 | Relationship between intraocular lens biomaterials and posterior capsule opacification显示文摘 | Ursell P G Spalton D J Pande M V | 1998 | J Cataract Refract Surg1998，24，3： | 1 |
| 16 | Performance evaluationand design trade-offs for network-on-chip interconnectarchitectures显示文摘 | Pande P P Grecu C Jones M | 2005 | IEEE Transactions on Computers2005，54，8： | 1 |
| 17 | Relationship between intraocular lens bio-materials and posterior capsule opacification 显示文摘 | Ursell P G Spalton D J Pande M V | 1998 | J Cataract Refract Surg1998，24，3： | 1 |
| 18 | Plant availabili- ty of nickel as influenced by farmyard manure and its critical toxic limits in french bean显示文摘 | PANDE J SRIVASTAVA P C SINGH S K | 2012 | Journal of Plant Nutrition2012，35，： | 1 |
| 19 | Anatomy of highperformance 2D similarity calculations显示文摘 | Haque I S Pande V S Walters W P | | 0，，09： | 1 |
| 20 | Use of distillery waste as a fertilizer显示文摘 | PANDE H P SINHA B K SINGH G B | 1995 | Sugarcane: agro-industrial alternatives1995，，： | 1 |
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