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| 1 | Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma显示文摘Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse,steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative potential, but fewer than 20% of patients are suitable candidates. Interventional treatments are offered to the vast majority of patients. Radiofrequency(RFA) and microwave ablation(MWA) are among the therapeutic modalities, with similar indications which include the presence of up to three lesions, smaller than 3 cm in size, and the absence of extrahepatic disease. The therapeutic effect of both methods relies on thermal injury, but MWA uses an electromagnetic field as opposed to electrical current used in RFA. Unlike MWA, the effect of RFA is partially limited by the heat-sink effect and increased impedance of the ablated tissue. Compared with RFA, MWA attains a more predictable ablation zone, permits simultaneous treatment of multiple lesions, and achieves larger coagulation volumes in a shorter procedural time. Major complications of both methods are comparable and infrequent(approximately 2%-3%), and they include haemorrhage, infection/abscess, visceral organ injury, liver failure, and pneumothorax. RFA may incur the additional complication of skin burns. Nevertheless, there is no compelling evidence for differences in clinical outcomes, including local recurrence rates and survival. | Loukia S Poulou Evanthia Botsa Ioanna Thanou Panayiotis D Ziakas Loukas Thanos | 2015 | World Journal of Hepatology2015，7，8： | 37 |
| 2 | Modified porous tantalum rod technique for the treatment of femoral head osteonecrosis显示文摘AIM: To study a modified porous tantalum technique for the treatment of osteonecrosis of the femoral head.METHODS: The porous tantalum rod was combined with endoscopy,curettage,autologous bone grafting and use of bone marrow aspirates from iliac crest aspiration in 49 patients(58 hips) with a mean age of 38 years.The majority of the patients had idiopathic osteonecrosis,followed by corticosteroid-induced osteonecrosis.Thirtyeight hips were of Steinberg stage Ⅱ disease and 20 hips were of stage Ⅲ disease.Patients were followed for 5 years and were evaluated clinically with the Merle D'Aubigne and Postel score and radiologically.The primary outcome of the study was survival based on the conversion to total hip arthroplasty(THA).Secondary outcomes included deterioration of the osteonecrosis to a higher disease stage at 5 years compared to the preoperative period and identification of factors that were associated with survival.The Kaplan-Meier survival analysis was performed to evaluate the survivorship ofthe prosthesis,and the Fisher exact test was performed to test associations between various parameters with survival.RESULTS: No patient developed any serious intraoperative or postoperative complication including implant loosening or migration and donor site morbidity.During the 5-year follow up,1 patient died,7 patients had disease progression and 4 hips were converted to THA.The 5-year survival based on conversion to THA was 93.1% and the respective rate based on disease progression was 87.9%.Stage Ⅱ disease was associated with statistically significant better survival rates compared to stage Ⅲ disease(P = 0.04).The comparison between idiopathic and non-idiopathic osteonecrosis and between steroid-induced and non-steroid-induced osteonecrosis did not showed any statistically significant difference in survival rates.The clinical evaluation revealed statistically significantly improved Merle d'Aubigne scores at 12 mo postoperatively compared to the preoperative period(P < 0.001).The mean preoperative Merle d'Aubigne score was 13.0(SD: 1.8).The respective score at 12 mo improved to 17.0(SD: 2.0).The 12-mo mean score was retained at 5 years.CONCLUSION: The modified porous tantalum rod technique presented here showed encouraging outcomes.The survival rates based on conversion to THA are the lowest reported in the published literature. | Emilios E Pakos Panayiotis Megas Nikolaos K Paschos Spyridon A Syggelos Antonios Kouzelis Georgios Georgiadis Theodoros A Xenakis | 2015 | World Journal of Orthopedics2015，6，10： | 20 |
| 3 | Seminal characteristics and sexual behavior in men of different age groups: is there an aging effect?显示文摘瞄准:估计精液的特征以及各种各样的年龄组的人的性行为在那些特征上建立变老的效果的存在。方法:精液样品从人被收集(n = 792 ) 仅仅在女因素不孕的情况下经历在试管内授精或子宫内的授精。样品在交际用一台精液的收集设备被收集并且根据世界卫生组织手工地评估了() 标准。人们根据他们的年龄被划分成四个组:(i) 20-30,(i i ) 31-40,(iii ) 41-50 并且(iv ) 到一张性行为问询表的 51-60 年,和他们的精液的特征和回答被比较。结果:数据统计上在测试的精液的特征显示出有效差量最尤其是在精子集中,活动性,活动性的等级,低亚硫酸钠渗透的胀大和正常精子形态学。而且,当使用严格的标准时,在有年龄的正常精子形态学的衰落是更显著的而非标准。也在全部的精子计数有差别,总计能动精子并且总计功能的精子部分(估计了由并且严格的标准) 。有效差量也以他们一直在试试到 conceive,性频率和性满足的年的数字在老人在性行为范型被观察。结论:数据当他们变老,清楚地在人在精液特征和性行为上说明变老的效果。当在构画出由的平淡的精液分析为精液特征建议正常的标准值时,变老的效果被考虑,这被建议标准。 | Panayiotis M. Zavos Khalied Kaskar Juan R. Correa Suresh C. Sikka | 2006 | Asian Journal of Andrology2006，8，3： | 10 |
| 4 | 丹江口水库蓄水后汉江中下游水文时空变化的定量评估及其生态影响显示文摘采用变化范围法(RVA)定量研究了丹江口水库蓄水后汉江中下游水文情势的时空变化,评估出汉江干流变化度最大的江段和水文特征指标类别,分析了其对应的生态影响,并针对汉江流域的四大家鱼和水华问题进行了敏感水文指标的变化度分析。结果显示:丹江口大坝蓄水后,汉江下游河道流量是中变化度占主导,比例范围为47~63%;水位是高变化度占主导,襄阳站和皇庄站高变化度的水文指标所占比例远大于其它站点,依次为53%和75%,各站水位较蓄水前下降了1~2 m。黄家港站高/低流量脉冲出现的频率减少(变化度为-0.49和-0.62),且持续的时间变短(变化度为-0.87和-0.74)。皇庄站和襄阳站流量和水位的月均值和极值较蓄水前减少,逆转次数在高RVA范围内较蓄水前增加(变化度为1.82)。四大家鱼产卵的敏感水文指标出现频率较蓄水前减少,且为中高变化度。下游河道枯水期流量和水位减小,增加了水华发生几率。 | 柏慕琛 班璇 DIPLAS Panayiotis 肖飞 | 2017 | 长江流域资源与环境2017，26，9： | 10 |
| 5 | Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis显示文摘BACKGROUND:Cirrhosis is associated with several extrahepatic manifestations including portopulmonary hypertension (PPHT).Recent data suggest that endothelins (ETs) are related to the pathophysiology of PPHT.The study aimed to measure serum ET levels in hospitalized cirrhotic patients and to determine their association with PPHT and patient outcome.METHODS:Fifty-seven cirrhotic patients [43 males;median age 58 (28-87) years] underwent Doppler echocardiography.Patients with systolic pulmonary arterial pressure ≥40 mmHg and pulmonary acceleration time <100 ms were deemed to have PPHT.ET-1,2,and 3 serum levels were measured with an ELISA assay.All-cause mortality was recorded over a median period of 24 months.RESULTS:Nine out of 57 patients (15.8%) had PPHT.Among various clinical variables,only autoimmune hepatitis was associated with PPHT (OR=11.5;95% CI,1.58-83.4;P=0.01).ET-1 levels [9.1 (1.6-20.7) vs 2.5 (1.4-9.2) pg/mL,P=0.02] and the ET-1/ET-3 ratio [4.73 (0.9-22.4) vs 1.6 (0.3-10.7),P=0.02] were significantly higher in patients with PPHT than in those without.ET-2 and ET-3 levels did not differ between the two groups.There was no difference in survival between the two groups,although ET-1 levels were associated with an adverse outcome in Cox regression analysis (HR=1.11;95% CI,1.02-1.22;P=0.02 per unit increase in ET-1).CONCLUSION:Our data suggest that ET-1 and the ET-1/ET-3 ratio are elevated in patients with PPHT and that ET-1 is associated with a poor outcome irrespective of PPHT. | Aristotelis Tsiakalos Gregorios Hatzis Ioannis Moyssakis Aggelos Karatzaferis Panayiotis D Ziakas George E Tzelepis | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 6 | Role of surgery in colorectal liver metastases:Too early or too late?显示文摘As colorectal cancer and colorectal liver metastases become a serious public health problem,new treatment modalities are needed in order to achieve better results. In the last decade there has been very important progress in oncology,with new and more effective chemotherapeutic agents administered alone or in combination improving the resectability rate in up to 40%of patients with colorectal liver metastases.Advances in interventional radiology,in particular,with the use of portal vein embolization and radiofrequency thermal ablation are new strategies allowing major liver resections and treatment of small liver metastases or early recurrences.Surgery,however,remains the gold standard strategy with intention to treat.In this review article we will describe the advanced role of surgery in the multidisciplinary approach to colorectal liver metastases,and the clinical problems the liver surgeon has to deal with,such as theresectability of the metastases,the presence of bilobar liver lesions and extrahepatic disease,the impact of chemotherapy in already resectable liver metastases,the problem of vanishing metastases after chemotherapy and the dilemma of staged or combined liver and colon operations and which organ first in the clinical scenario of synchronous colorectal liver metastases. | Dimitrios Dimitroulis Nikolaos Nikiteas Theodore Troupis Dimitrios Patsouras Panayiotis Skandalakis Gregory Kouraklis | 2010 | World Journal of Gastroenterology2010，16，28： | 5 |
| 7 | Research and development in drug innovation: reflections from the 2013 bioeconomy conference in China, lessons learned and future perspectives显示文摘The enormous progress biotechnology,bioinformatics and nanotechnology made in recent years provides opportunities and scientific framework for development of biomedicine and constitutes a paradigm shift in pharmaceutical R&D and drug innovation.By analyzing the data and related information at R&D level over the past decades,developmental tendency and R&D patterns were summarized.We found that a growing number of biologics in the pipeline of pharma companies with successful products already in the market though,small molecular entities have primarily dominated drug innovation.Additionally,small/medium size companies will continue to play a key role in the development of small molecule drugs and biologics in a multi-channel integrated process.More importantly,modern and effective R&D strategies in biomedicine development to predict and evaluate efficacy and/or safety of 21st century therapeutics are urgently needed.To face new challenges,developmental strategies were proposed,in terms of molecular targeted medicine,generic drugs,new drug delivery system and protein-based drugs.Under the current circumstances,interdisciplinary cooperation mode and policy related to drug innovation in China were deeply discussed as well. | Changxiao Liu Panayiotis P.Constantinides Yazhuo Li | 2014 | Acta Pharmaceutica Sinica B2014，4，2： | 5 |
| 8 | Nonlinear dynamic analysis of multi-base seismically isolated structures with uplift potentialⅡ:verification examples显示文摘当分析模型的数字确认在同伴纸发展了因为多底的非线性的动态分析地震地孤立结构,在这份报纸介绍的工作服务。到这个目的,二个数字例子用合并到节目 3D-BASIS-ME-MB 的计算算法被分析了,根据最新提出的分析模型发展了。第一个例子使在公牛在大学在地震模拟器上被测试并且也为节目 SAP2000 被用作一个确认例子的七故事的模型结构担心。第二个例子与一个段层式的地震隔离的系统使二塔的、有多层楼的结构担心。为确认的目的, 3D-BASIS-ME-MB 生产的关键结果与从另外的结构 / 有限的元素程序获得的试验性的结果,或结果相比。在两个例子,分析结构在适用的条件下面激动高举,因此产出对验证发达分析工具的能力的许多兴趣的一个盒子。关键词地震隔离 - 非线性的动态分析 - 高举 - 确认 - 多重上层建筑 / | Panayiotis C.Roussis Panos C.Tsopelas Michael C.Constantinou | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 5 |
| 9 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 10 | 长江葛洲坝下游鱼类资源量的关键水文指标识别显示文摘采用遗传规划法和相关系数法识别影响鱼类资源量的关键水文指标,结果显示坝下经济鱼类天然捕捞产量与年最大流量、高流量脉冲历时、10月和12月的月均流量正相关;四大家鱼鱼苗丰度与涨水率、7日最大流量、5月和6月的月均流量正相关;中华鲟繁殖群体数量与基流指数和涨水率呈正相关,与年最小流量、日均流量逆转次数负相关。这些水文指标分别反映了流量的量值、变化率和历时等特征对鱼类的影响。建立了关键水文指标与鱼类资源量之间的非线性函数关系式,通过对比计算值与实测值发现遗传规划法的拟合效果明显优于相关系数法,表明遗传规划法更适用于识别影响鱼类资源量的关键水文指标。 | 班璇 DIPLAS Panayiotis 吕晓蓉 肖飞 李书娟 | 2019 | 水利水电科技进展2019，39，1： | 4 |
| 11 | 中华鲟产卵栖息地的三维水力因子适宜性分析显示文摘建立三维水动力学模型分析中华鲟产卵栖息地水力因子的时空分布和中华鲟产卵时的适宜水力特性,为设计最佳的生态调度方案提供科技支撑。研究结果表明,中华鲟产卵栖息地的上产卵区水深和流速的变化主要受流量影响,涡量的变化主要受地形影响;中华鲟产卵前需要高流量脉冲刺激产卵。坝下与隔流堤之间流速和涡量值的大小与波动远大于其他区域,均值为2.4 m/s和11 m2/s。产卵栖息地水体表层、中层和底层的流速和水平涡量分布格局相似,均是在上产卵区值较大,空间分布多样性高。水体中层垂向涡量的值远大于底层和表层。产卵栖息地水体表层、中层和底层水力分布特征为中华鲟繁殖提供了有利的水力条件,体现出中华鲟对产卵栖息地不同功能区的自主选择性。 | 班璇 高欣 Panayiotis DIPLAS 肖飞 石小涛 | 2018 | 水科学进展2018，29，1： | 4 |
| 12 | A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon)显示文摘 | Constantinos Simillis Panayiotis Symeonides Andrew J. Shorthouse Paris P. Tekkis | 2010 | Surgery2010，，6： | 3 |
| 13 | Variable change in renal function by hypertonic saline显示文摘AIM: To investigate the effects of hypertonic saline in the neurocritical care population.METHODS: We retrospectively reviewed our hospital's use of hypertonic saline(HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change(Cr), and HS formulation(3% Na Cl, 3% Na Cl/sodium acetate mix, and 23.4% Na Cl) to patients receiving normal saline or lactated ringers. The patients(n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data. RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation Ⅱ scores and GlasgowComa Scale scores occurred between different saline formulations. No significant correlation of Cl- or Na+ with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury(TBI) patients demonstrated moderate correlation between Na+ and Cr of 0.45. Stroke patients demonstrated weak correlations between Na+ and Cr, and Cl- and Cr(0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl- and Cr at 0.29.CONCLUSION: Cr directly correlates with Na+ or Cl- in stroke, Na+ in TBI, and Cl- in other populations. Prospective comparison of HS and renal function is needed. | Jesse J Corry Panayiotis Varelas Tamer Abdelhak Stacey Morris Marlisa Hawley Allison Hawkins Michelle Jankowski | 2014 | World Journal of Critical Care Medicine2014，3，2： | 3 |
| 14 | Complications after tibia plateau fracture surgery显示文摘 | Panayiotis J. Papagelopoulos Antonios A. Partsinevelos George S. Themistocleous Andreas F. Mavrogenis Demetrios S. Korres Panayotis N. Soucacos | 2005 | Injury2005，，6： | 2 |
| 15 | 牛精液保存和质量评定显示文摘前言精液可以在-196℃的液氮中保存,解冻后仍具有较高的受精能力。尽管如此,冷冻—解冻后的精液中仍有不少精子死亡和失去活力。因此,为了获得较高的受精率,输精剂量一定要高于新鲜精液。卵黄或牛奶是牛冷冻精液稀释液的基本成分。 | Panayiotis M.Zavos 郭年藩 张才乔 | 1990 | 国外畜牧科技1990，17，1： | 2 |
| 16 | Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel显示文摘 | Panayiotis P. Constantinides Karel J. Lambert Alex K. Tustian Brian Schneider Salima Lalji Wenwen Ma Bryan Wentzel Dean Kessler Dilip Worah Steven C. Quay | 2000 | Pharmaceutical Research2000，，2： | 2 |
| 17 | Scalable Distributed Sensor Fault Diagnosis for Smart Buildings显示文摘The enormous energy use of the building sector and the requirements for indoor living quality that aim to improve occupants' productivity and health, prioritize Smart Buildings as an emerging technology. The Heating, Ventilation and Air-Conditioning(HVAC) system is considered one of the most critical and essential parts in buildings since it consumes the largest amount of energy and is responsible for humans comfort. Due to the intermittent operation of HVAC systems, faults are more likely to occur, possibly increasing eventually building's energy consumption and/or downgrading indoor living quality. The complexity and large scale nature of HVAC systems complicate the diagnosis of faults in a centralized framework. This paper presents a distributed intelligent fault diagnosis algorithm for detecting and isolating multiple sensor faults in large-scale HVAC systems.Modeling the HVAC system as a network of interconnected subsystems allows the design of a set of distributed sensor fault diagnosis agents capable of isolating multiple sensor faults by applying a combinatorial decision logic and diagnostic reasoning. The performance of the proposed method is investigated with respect to robustness, fault detectability and scalability. Simulations are used to illustrate the effectiveness of the proposed method in the presence of multiple sensor faults applied to a 83-zone HVAC system and to evaluate the sensitivity of the method with respect to sensor noise variance. | Panayiotis M.Papadopoulos Vasso Reppa Marios M.Polycarpou Christos G.Panayiotou | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，3： | 2 |
| 18 | Nonlinear dynamic analysis of multi-base seismically isolated structures with uplift potential Ⅰ:formulation显示文摘现代地震联盟者的复杂性孤立结构在它捕获象隔离乾那样的潜在的不连续的现象的全部和能力要求结构的系统和隔离系统的分析高举并且他们上层建筑和隔离硬件上的效果。在这篇论文,一个分析模型被开发,一个计算算法被提出分析复杂地震联盟者甚至当经历高度非线性的现象例如时,孤立上层建筑高举。计算模型有与强壮的非线性为隔离设备的各种各样的类型建模的能力,分析多重底(多达五个底) 上的多重上层建筑(多达五座分开的上层建筑) ,并且捕获忍受轴的力量上的侧面的负担的效果,包括适用高举。此处开发的模型被利用了形成软件平台 3D-BASIS-ME-MB,它与现代隔离系统为复杂结构的分析和设计向练习工程社区提供一个万用的工具。 | Panos C.Tsopelas Panayiotis C.Roussis Michael C.Constantinou | 2009 | Earthquake Engineering and Engineering Vibration2009，8，3： | 2 |
| 19 | Public Sector Technical Inefficiency in Large U.S. Cities显示文摘 | Philip J Grossman Panayiotis Mavros Robert W Wassmer | 1999 | Journal of Urban Economics1999，，2： | 2 |
| 20 | Accurate Assessment of Patient Effective Radiation Dose and Associated Detriment Risk From Radiofrequency Catheter Ablation Procedures显示文摘 | Kostas Perisinakis John Damilakis Nicholas Theocharopoulos Emmanouel Manios Panayiotis Vardas Nicholas Gourtsoyiannis | 2001 | Circulation: Journal of the American Heart Association2001，，1： | 2 |
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