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	题名	作者	年代	出处	被引量
1	Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment显示文摘Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and even among individual tumor regions.In recent years,large-scale genomic studies and new next-generation sequencing technologies have uncovered more scientifc details about tumor heterogeneity,with significant implications for the choice of specific molecular biomarkers and clinical decision making Genomic heterogeneity signifcantly contributes to the generation of a diverse cell population during tumor development and progression,representing a determining factor for variation in tumor treatment response.It has been considered a prominent contributor to therapeutic failure,and increases the likelihood of resistance to future therapies in most common cancers.The understanding of molecular heterogeneity in cancer is a fundamental component of precision oncology,enabling the identification of genomic alteration of key genes and pathways that can be targeted therapeutically.Here,we review the emerging knowledge of tumor genomics and heterogeneity,as well as potential implications for precision medicine in cancer treatment and new therapeutic discoveries.An analysis and interpretation of the TCGA database was included.	Jialing Zhang Stephan Stanislaw Späth Sadie L.Marjani Wengeng Zhang Xinghua Pan	2018	Precision Clinical Medicine2018，1，1：	5
2	Biomechanical ana- lysis of alveolar bone stress around implants with different thread designs and pitches in the mandi- bular molar area显示文摘	Lan TH Du JK Pan CY	2012	Clin Oral Investig2012，16，2：	1
3	Biomechanical analysis of alveolar bone stress around implants with different thread designs and pitches in the mandibular molar area显示文摘	Lan TH Du JK Pan CY		0，，02：	1
4	Effects of deep brain stimulation in relatively young-onset multiple system atrophy Parkinsonism 显示文摘	Zhu XY Pan TH Ondo WG	2014	J Neurol Sci2014，342，12：	1
5	Location and size of infarct on functional outcome of noncardioembolic ischemic stroke显示文摘	Pan SL Wu SC Wu TH	2006	Disabil Rehabil2006，28，：	1
6	Small functional adrenal cortical adenoma:treatment with CT -guided percutaneous acetic acid injection-report of three cases显示文摘	Liang HL Pan HB Lee TH	1999	Radiology1999，213，2：	1
7	Effects of green tea polyphenols on dopamine uptake and on MPP^+-induced dopamine neuron injury显示文摘	Pan TH Fei J Zhou XD	2003	Life Sci2003，72，9：	1
8	Use of Pseudomonas putida EstA as an anchoring motif for display of a periplasmic enzyme on the surface of Escherichia coli显示文摘	Yang TH Pan JG Seo YS	2004	Appl Environ Microbio2004，70，12：	1
9	Biological effects of pramipexole on dopaminergic neuron-associated genes:relevance to neuroprotection显示文摘	PAN TH XIE W JANKOVIC J	2005	Neurosci Lett2005，377，2：	1
10	Trace elements in hair of patients with blackfoot disease显示文摘	PAN TC LIN TH TSENG C I	1993	Biol Trace Elem Res1993，39，：	1
11	Upper thoracic sympathectomy for axillary osmidrosis or bromidrosis显示文摘	Kao TH Pan HC Sun MH	2004	J Clin Neurosci2004，11，7：	1
12	Effect of Mn - Zn ferrite on apatite - wollastonite glass - ceramic ( A - W GC ) 显示文摘	Da LG Zhou DL Pan TH	2009	Biomed Mater2009，4，04：	1
13	cnlorectal cancer incidence among young adults in california 显示文摘	Singh KE Taylor TH Pan CG	2014	Adolesc Young Adult On- col2014，3，4：	1
14	Moscatilin induces apoptosis inhuman colorectal cancer cells; a crucial role of c-Jun NH2-terminalprotein kinase activation caused by tubulin depolymerization andDNA damage显示文摘	Chen TH Pan SL Guh JH	2008	Clin Cancer Res2008，14，42：	1
15	Upper thoraciu sympathectomy for axillary osmidrosis or bromidrosis显示文摘	Kao TH Pan HC Sun MH eI al	2004	J Clin Neurosci2004，11，7：	1
16	Efficacy and tolerability be- tween an olmesartan/amlodipine fixed-dose combination and an amlodipine double dose in mild to moderate hypertension 显示文摘	LIN TH TSAI CD PAN JP	2013	Kaohsiung J Med Sci2013，29，5：	1
17	Roles of autophagy in cetux-imab-mediated cancer therapy against EGFR显示文摘	Li XQ Lu Y Pan TH	2010	Autophagy2010，6，8：	1
18	Ca2+oscillatory pattern in fertilized mouse eggs affects gene expression and development to term显示文摘	Ozil J P Banrezes B Tóth S Pan H	2006	Dev Biol2006，300，2：	1
19	Localization of nerve growth factor, trkA and P75 immunoreactivity in the hippocampal formation and basal forebrain of adult rats显示文摘	Lee TH Kato H Pan LH	1998	Neuroscience1998，83，4：	1
20	Fluorimetric liquid chromatographic analysis of amantadine in urine and pharmaceutical formulation显示文摘	Duh TH Wu HL Pan CW	2005	J Chromatogr A2005，1088，12：	1

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