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| 1 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 2 | Terahertz endoscopic imaging for colorectal cancer detection:Current status and future perspectives显示文摘Terahertz(THz) imaging is progressing as a robust platform for myriad applications in the field of security,health,and material science.The THz regime,which comprises wavelengths spanning from microns to millimeters,is non-ionizing and has very low photon energy:Making it inherently safe for biological imaging.Colorectal cancer is one of the most common causes of death in the world,while the conventional screening and standard of care yet relies exclusively on the physician's experience.Researchers have been working on the development of a flexible THz endoscope,as a potential tool to aid in colorectal cancer screening.This involves building a single-channel THz endoscope,and profiling the THz response from colorectal tissue,and demonstrating endogenous contrast levels between normal and diseased tissue when imaging in reflection modality.The current level of contrast provided by the prototype THz endoscopic system represents a significant step towards clinical endoscopic application of THz technology for invivo colorectal cancer screening.The aim of this paper is to provide a short review of the recent advances in THz endoscopic technology and cancer imaging.In particular,the potential of single-channel THz endoscopic imaging for colonic cancer screening will be highlighted. | Pallavi Doradla Cecil Joseph Robert H Giles | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 3 |
| 3 | Influence of salts and alcohols on the conformation of partially folded intermediate of stem bromelain at low pH显示文摘 | SOGHRA K H SHEEBA R PALLAVI S | 2005 | The International Journal of Biochemistry & Cell Biology2005，37，2： | 1 |
| 4 | Screening and assessment of laccase producing fungi isolated from different envi~ ronmental samples 显示文摘 | Viswanath B Chandra M S Pallavi H | 2008 | Afr J Biotechno12008，7，8： | 1 |
| 5 | Studies on pullout capacity of anchors in marine clays for mooring systems 显示文摘 | RAO S N LATHA K H PALLAVI B | 2006 | Applied Ocean Research2006，28，： | 1 |
| 6 | Medical image segmentation based on vigorous smoothingand edge detection ideology显示文摘 | Pujar Jagadish H Gurjal Pallavi S Shambhavi I) S | 2010 | International Journal of E-lectrical Computer Energetic and Computer Engineering2010，4，8： | 1 |
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