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| 1 | Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors显示文摘AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013') with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas.RESULTS: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size. | Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge | 2015 | World Journal of Gastrointestinal Surgery2015，7，4： | 23 |
| 2 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 3 | Acupuncture Treatment for Idiopathic Trigeminal Neuralgia:A Longitudinal Case-Control Double Blinded Study显示文摘Objective: To evaluate the treatment effect of acupuncture on patients with idiopathic trigeminal neuralgia(ITN) by case-control longitudinal blinded study. Methods: Sixty ITN patients and 30 healthy subjects were included. The ITN patients were randomly assigned to acupuncture group(15 cases), sham-acupuncture group(15 cases) and carbamazepine group(30 cases), respectively. Clinical orofacial evaluation(including pain intensity and medication doses), research diagnostic criteria for temporomandibular disorders(RDC/TMD) and Helkimo indexes(for functional evaluation of the masticatory system), and quantitative sensory testing for sensory thresholds(gustative, olfactory, cold, warm, touch, vibration and superficial and deep pain) were evaluated before treatment, immediately after treatment, and 6 months after treatment. Results: The mean pain intensity by the Visual Analogue Scale only decreased in the acupuncture group at the last evaluation(P=0.012). Patients in the sham-acupuncture group had an increase in carbamazepine doses according to the prescriptions(P<0.01). There was a reduction in secondary myofascial pain and mandibular limitations at the acupuncture and sham-acupuncture groups, however only the acupuncture group kept the changes after 6 months(P<0.01, P=0.023). There was a decrease in mechanical thresholds in the acupuncture group(tactile, P<0.01; vibration, P=0.027) and an increase in deep pain thresholds in both acupuncture and sham-acupuncture groups(P=0.013). Conclusion: Acupuncture can be an option in the treatment of ITN due to its analgesic effect in both ITN and secondary myofascial pain associated with it. | Michelle Cristina Ichida Mariana Zemuner Jorge Hosomi Hong Jin Pai Manoel Jacobsen Teixeira JoséTadeu Tesseroli de Siqueira Silvia R D T de Siqueira | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 6 |
| 4 | 脂肪肝、特定部位和多部位动脉粥样硬化与10年心血管风险评估的关系显示文摘【据《Hepatology》2018年8月报道】题:脂肪肝、特定部位和多部位动脉粥样硬化与10年心血管风险评估的关系(作者PaisR等)尽管脂肪肝患者的亚临床动脉粥样硬化患病率明显增加,但脂肪肝与动脉粥样硬化,特定部位、多部位动脉粥样硬化和心血管风险预测之间的关系尚未完全了解。研究了2554例具有大于1项心血管危险因素患者的脂肪变性、动脉粥样硬化的发生部位、多部位动脉粥样硬化、冠状动脉钙化(CAC)和10年心血管风险评分(FRS)之间的关系,排除了心血管意外事件、其他慢性肝病以及饮酒<50g/d的患者。 | Pais R 罗利婷 牛俊奇 | 2019 | 临床肝胆病杂志2019，35，1： | 4 |
| 5 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 6 | Helicobacter pylori culture supematant interferes with epidermal growth factor-activated signal transduction in human gastric KATO Ill cells 显示文摘 | Pai R Wyle FA Cover TL | 1998 | Am J Pathol1998，152，6： | 1 |
| 7 | Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation显示文摘 | Pai R Lin C Tran T | 2005 | Biochem Biophys Res Commun2005，331，： | 1 |
| 8 | Surface roughness and its effects on the heat transfer mechanism in spray cooling 显示文摘 | Pais M R Chow L C Mathefdey E T | 1992 | ASME Journal of Heat Transfer1992，114，1： | 1 |
| 9 | Pedunculated cribriform adenocarcinoma of the base of the tongue显示文摘 | Prasad K C Kaniyur V Pai R R | 2004 | Ear Nose Throat J2004，83，1： | 1 |
| 10 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 11 | PLD growth of CuAlO2 显示文摘 | Neumann-Spallart M Pai S P Pinto R | 2007 | Thin Solid Films2007，515，24： | 1 |
| 12 | Sensitivity based selection of control parameters for multimachine power systems显示文摘 | Padiyar K R | 1980 | IEEE Trans on Power Apparatus and Systems1980，99，： | 1 |
| 13 | A complete equipment cir- cuit of a linear induction motor with sheet secondary 显示文摘 | PAI R M ION Boldea NASAR S A | 1988 | IEEE Transactions on Magnetics1988，24，1： | 1 |
| 14 | Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models显示文摘 | Desnoyers LR Pai R Ferrando RE | | 0，，01： | 1 |
| 15 | Survival after cardiopulmonary resuscitation in an urban Indian hospital显示文摘 | Rajaram R Rajagopalan RE Pai M | 1999 | Natl Med J India1999，12，2： | 1 |
| 16 | Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma显示文摘 | Ward C Pais M Bish R | 2002 | Thorax2002，57，4： | 1 |
| 17 | Mast cell profile in uterine cervix 显示文摘 | Naik R Pai MR Poornima-Baliga B | 2004 | Indian J Pathol Microbiol2004，47，2： | 1 |
| 18 | Prostaglandins promote colon cancer cell invasion;signaling by cross-talk between two distinct growth factor receptors 显示文摘 | Pai R Nakamura T Moon WS | 2003 | FASEB J2003，17，： | 1 |
| 19 | Anal- ysis of water - lubricated journal bearings with multiple axial Grooves 显示文摘 | MAJUMDAR B C PAI R HARGREAVES D J | 2004 | Journal of Engineering Tribology2004，218，： | 1 |
| 20 | Mass mortality of Penae- us monodon larvae due to antibiotic -resistant Vibrio harveyi infection 显示文摘 | KARUNASAGAR I PAI R MALATHI G R | 1994 | Aquaculture1994，128，34： | 1 |
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