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| 1 | FIT阳性结直肠癌筛查对象的结肠胶囊内窥镜检查与CT结肠成像检查对比:一项前瞻性随机试验--VICOCA研究显示文摘背景:结肠胶囊内窥镜检查(colon capsule endoscopy,CCE)和CT结肠成像(CT colonography,CTC)是用于结直肠癌(CRC)筛查的微创技术。我们的目的在于比较CCE和CTC在CRC筛查发现粪便免疫化学试验(faecal immunochemicaltest,FIT)阳性的受试者中识别结直肠肿瘤患者的效能。主要研究结果是CCE和CTC检出肿瘤性病变效能的比较。方法:VICOCA研究是一项于2014年3月至2016年5月进行的前瞻性、单中心随机试验。在进行结肠镜检查之前,共向662人提出检查建议,其中349人被随机分入CCE组或CTC组。内镜医师并未知晓CCE和CTC检查的结果。结果:共349人纳入分组,其中CCE组173人、CTC组176人。共290人同意参加该研究,其中CCE组147人、CTC组143人。在意向筛查分析中,CCE组检出结直肠肿瘤的敏感度、特异度、阳性预测值和阴性预测值分别为98.1%、76.6%、93.7%和92.0%,CTC组相应分别为64.9%、95.7%、96.8%和57.7%。在检出显见的肿瘤性病变方面,CCE组和CTC组的敏感度分别为96.1%和79.3%。CCE组对晚期结直肠肿瘤的检出率有相比CTC组更高的趋势(分别为100%和93.1%,RR=1.07,P=0.08)。CCE组和CTC组均识别出所有癌症患者。CCE组检出存在任一肿瘤性病变患者的比例高于CTC组(分别为98.6%和81.0%,RR=1.22,P=0.002)。结论:虽然两种技术在识别晚期结直肠肿瘤患者方面的效能相近,但CCE检出任一肿瘤性病变的敏感度更高。 | 佟伟华 GONZáLEZ-SUáREZ B PAGéS M ARAUJO I K | 2020 | 结直肠肛门外科2020，26，6： | 4 |
| 2 | Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model显示文摘AIM:To investigate the role of epidermal growth factor receptor(EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor erlotinib.METHODS:Sprague-Dawley rats received trinitrobenzene sulfonic acid(TNBS;30 mg in 50% ethanol,ic),followed 6 wk later by reactivation with TNBS(5 mg/kg,iv) for 3 d.To induce colitis-associated dysplasia,rats then received TNBS(iv) twice a week for 10 wk.One group received erlotinib(10 mg/kg,ip) for 1 wk before the start of the reactivation of the colitis and 2 wk after(21 d);the rest received the vehicle.After rats were euthanized,the colons were removed and analyzed for damage and expression of the EGFR downstream effectors Erk1/2 and c-Myc.RESULTS:Ninety percent of the vehicle-treated animals had dysplasia in any region of the colon.Erlotinib-treated animals had a significant decrease in the incidence of dysplasia compared to vehicle-treated animals in all regions of the colon(50.00% ± 11.47% vs 90.00% ± 10.00% in proximal,P < 0.05;15.00% ± 8.19% vs 50.00% ± 16.67% in mid,P < 0.05;and 20.00% ± 9.17% vs 70.00% ± 15.28% in distal,P < 0.01).Erlotinib-treated animals also had reduced cell proliferation,reduced active Erk1/2,and reduced c-Myc in colon epithelium compared with the vehicle-treated animals.In vitro,erlotinib treatment was shown to markedly decrease c-Myc and pErk1/2 levels in rat epithelial cells.Proliferation of rat epithelial cells was stimulated by epidermal growth factor and inhibited by erlotinib(P < 0.05).CONCLUSION:Erlotinib can decrease the development of colitis-associated dysplasia,suggesting a potential therapeutic use for erlotinib in patients with long-standing colitis. | Beatriz Pagán Angel A Isidro Myrella L Cruz Domenico Coppola Caroline B Appleyard | 2011 | World Journal of Gastroenterology2011，17，44： | 1 |
| 3 | A new fluorimetric assay for cytotoxity measurements in vitro 显示文摘 | Pag B Page M Noe I C | 1993 | International Journal of Oncology1993，3，： | 1 |
| 4 | Transfusion and recombinant human erythropoietin requirements differ between dialysis modalities显示文摘 | House AA Pham B Pagé DE | 1998 | Nephrol Dial Transplant1998，13，7： | 1 |
| 5 | A new fluorimetric assay for cytotoxity measurements in vitro显示文摘 | Pagé B Pagé M Noèl C | 1993 | International Journal of Oncology1993，3，： | 1 |
| 6 | Optimization of the tetrazolium-based colorimetric assay for the measurement of cell number and cytotoxicity显示文摘 | Pag~ M Bejaoui N Cinq M B | 1988 | Int J Immunopharmacol1988，10，： | 1 |
| 7 | G proteincoupled receptor 84,a microglia-associated protein expressed in neuroinflammatory conditions显示文摘 | Bouchard C Pagé J Bédard A | 2007 | Glia2007，55，： | 1 |
| 8 | A systematic study of topographical memory and posterior cerebral artery infarctions显示文摘 | Busigny T Pagès B Barbeau EJ | 2014 | Neurology2014，83，： | 1 |
| 9 | cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization显示文摘 | Rasmussen U B Vouret-Craviari V Jallat S Sehlesinger Y Pag(e)s G Pavirani A | 1991 | FEBS Lett1991，288，： | 1 |
| 10 | Tranfusion and recombinant human erythropoietin requirements differ between dialysis modalities 显示文摘 | House A A Pham B Pag D E | 1996 | Nephrol Dial Transplant1996，13，7： | 1 |
| 11 | G protein-coupled receptor 84,a microglia-associated protein expressed in neuroinflammatory conditions显示文摘 | Bouchard C PagéJ Bédard A | 2007 | Glia2007，55，： | 1 |
| 12 | IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines显示文摘 | Sophie Molet Qutayba Hamid Francis Davoine b Esra Nutku Rame Taha a Nathalie Pagé Ron Olivenstein Jack Elias Jamila Chakir | 2001 | The Journal of Allergy and Clinical Immunology2001，，3： | 1 |
| 13 | Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability显示文摘 | Jorge Gracia‐Sancho Bàrbara Lavi?a Aina Rodríguez‐Vilarrupla Héctor García‐Calderó Mercedes Fernández Jaume Bosch Joan‐Carles García‐Pagán | 2008 | Hepatology2008，，4： | 1 |
| 14 | Multiple factor analysis and clustering of a mixture of quantitative, categorical and frequency data显示文摘 | Mónica Bécue-Bertaut Jér?me Pagès | 2007 | Computational Statistics and Data Analysis2007，，6： | 1 |
| 15 | Derivative Asset Pricing with Transaction Cost显示文摘 | Bensaid B Lesne J P Pagès | 1992 | Mathematical Finance1992，，2： | 1 |
| 16 | Root system architecture:Opportunities and constraints for genetic improvement of crops显示文摘 | de Dorlodot S Forster B Pagès L | | 0，，10： | 1 |
| 17 | Isolation of an attenuated myxoma virus field strain that can confer protection against myxomatosis on contacts of vaccinates显示文摘 | Bárcena J Pagès-MantéA March R | 2000 | Arch Virol2000，145，4： | 1 |
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