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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Guillain–Barré syndrome, transverse myelitis and infectious diseases显示文摘Guillain–Barrésyndrome(GBS)and transverse myelitis(TM)both represent immunologically mediated polyneuropathies of major clinical importance.Both are thought to have a genetic predisposition,but as of yet no specific genetic risk loci have been clearly defined.Both are considered autoimmune,but again the etiologies remain enigmatic.Both may be induced via molecular mimicry,particularly from infectious agents and vaccines,but clearly host factor and co-founding host responses will modulate disease susceptibility and natural history.GBS is an acute inflammatory immune-mediated polyradiculoneuropathy characterized by tingling,progressive weakness,autonomic dysfunction,and pain.Immune injury specifically takes place at the myelin sheath and related Schwann-cell components in acute inflammatory demyelinating polyneuropathy,whereas in acute motor axonal neuropathy membranes on the nerve axon(the axolemma)are the primary target for immune-related injury.Outbreaks of GBS have been reported,most frequently related to Campylobacter jejuni infection,however,other agents such as Zika Virus have been strongly associated.Patients with GBS related to infections frequently produce antibodies against human peripheral nerve gangliosides.In contrast,TM is an inflammatory disorder characterized by acute or subacute motor,sensory,and autonomic spinal cord dysfunction.There is interruption of ascending and descending neuroanatomical pathways on the transverse plane of the spinal cord similar to GBS.It has been suggested to be triggered by infectious agents and molecular mimicry.In this review,we will focus on the putative role of infectious agents as triggering factors of GBS and TM. | Yhojan Rodríguez Manuel Rojas Yovana Pacheco Yeny Acosta-Ampudia Carolina Ramírez-Santana Diana M Monsalve M Eric Gershwin Juan-Manuel Anaya | 2018 | Cellular & Molecular Immunology2018，15，6： | 7 |
| 3 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 4 | Successful operation of a cooperative SLR station of China and Argentina in San Juan显示文摘We introduced the observations and researches using a Satellite Laser Ranging (SLR) system with high precision, which was designed and made in China and installed in the Observatory of San Juan Uni- versity, Argentina, the capability of the system and the achievement of the cooperative procedure be- tween China and Argentina. The SLR station in San Juan, set up by China and Argentina, is quite sig- nificant for improving the distribution of SLR stations and enhancing the orbital coverage of the whole earth. Since the SLR system started to work in the Observatory of San Juan University in the beginning of 2006, the operation is rather good, and rich data with high precision have been obtained. Further plan of the cooperation for the near future is also presented. | HAN YanBen LIU WeiDong E ACTIS R PODESTA WANG TanQiang GUO TangYong QU Feng A M PACHECO A A GONZALEZ E ALONSO XIANG QingGe HUANG DongPing YIN ZhiQiang | 2008 | Chinese Science Bulletin2008，53，16： | 2 |
| 5 | Evaluation of genetically engineered derivatives of a chinese strain of foot-and-mouth disease virus reveals a novel cell-binding site which functions in cell culture and in animals 显示文摘 | Zhao Q Z Pacheco M Mason P W | 2003 | J Virol2003，77，5： | 1 |
| 6 | Active linking in evolutionary games显示文摘 | Traulsen A Nowak M A | 2006 | Journal of Theoretical Biology2006，243，3： | 1 |
| 7 | Selenium and aflatoxin levels in raw Brazil nuts from the Amazon basin 显示文摘 | PACHECO A M SCUSSEL1 V M | 2007 | J Agrle Food Chem2007，55，11： | 1 |
| 8 | Preparation of palladium and silver alloy membrane on a porous or-alumina tube via simultaneous electroless plating 显示文摘 | PACHECO TANAKA D A LLOSA TANCO M A NIWA S | 2005 | J Membr Sci2005，247，12： | 1 |
| 9 | An experimental and analytical study of autoparametric resonance in a 3DOF model of cable-stayed-beam 显示文摘 | Fujino Y Wamitchai P Pacheco B M | 1993 | Nonlinear Dynamics1993，4，2： | 1 |
| 10 | Active stiffness control of cable vibration 显示文摘 | Fujino Y Warnitchai P Pacheco B M | 1993 | Journal of Applied Mechanics ASME1993，60，4： | 1 |
| 11 | Investigation of cold filling reeeiverpanels and piping in molten - nit - rate - salt central - receiver solar power plants 显示文摘 | PACHECO J E RALPH M E | 1994 | Journal of Solar Energy Engineering1994，117，4： | 1 |
| 12 | An investigation of the dependent of atmospheric corrosion rate on temperature using printed-circuit iron cells 显示文摘 | A M G Pacheco M G S Ferreira | 1994 | Corrosion Science1994，36，5： | 1 |
| 13 | Prognostic significance of the combined expression of matrix metalloproteinase-9, urokinase type plasminogen activator and its receptor in breast cancer as measured by Northern blot analysis 显示文摘 | Pacheco MM Nishimoto IN Mour? o Neto M | 2001 | Int J Biol Markers2001，16，1： | 1 |
| 14 | Role of nonstructural proteins 3A and 3B in host range and pathogenicity of foot-and-mouth disease virus显示文摘 | Pacheco J M Henry T M O'Donnell V K | 2003 | JVirol2003，77，24： | 1 |
| 15 | Should tetracycline treatment be used more extensively for rheumatoid arthritis? Metaanalysis demonstrates clinical benefit with reduction in disease activity显示文摘 | Stone M Fortin P R Pacheco -Tena C | 2003 | J Rheumatol2003，30，10： | 1 |
| 16 | 显示文摘 | Lopez de Alba P L Pacheco M Urbina B | 1988 | Rev Cubana Quim1988，4，： | 1 |
| 17 | Coevolution of strategy and structure in complex networks with dynamic linking 显示文摘 | Pacheco J M Traulsen A Nowak M A | 2006 | Phys Rev Lett2006，97，25： | 1 |
| 18 | Synchronization of human walking observed during lateral vibration of a congested pedestrian bridge 显示文摘 | Fujino Y Pacheco B M Nakamura S | 1993 | Earthquake Engineer- ing and Structural Dynamics1993，22，： | 1 |
| 19 | Social and clinical comparison between schizophrenia and bipolar disorder type I with psychosis in costa rica显示文摘 | Pacheco A Barguil M Contreras J | 2009 | Soc Psychiatry Psychiatr Epidemiol2009，30，8： | 1 |
| 20 | Expression of a novel factor,com1,in early tumor progression of breast cancer显示文摘 | Ree AH Pacheco MM Tvermyr M | 2000 | Clin Cancer Res2000，6，5： | 1 |
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