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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 3 | Prognostic significance of progesterone receptor-positive tumor cells within immunohis- tochemically defined luminal a breast cancer 显示文摘 | Prat A Cheang MC Martin M | 2013 | J Clin On- col2013，31，2： | 1 |
| 4 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 5 | Extracorporeal high-intensity focused ultrasound for VX2 liver tumors in therabbit显示文摘 | PRAT F CENTARTI M SIBILLE A etal | 1995 | Hepatology1995，21，2： | 1 |
| 6 | Deconstructing the molecular portraits of breast cancer显示文摘 | PRAT A PEROU C M | 2011 | Mol Oncol2011，5，1： | 1 |
| 7 | Deconstructing the molecular portraits of breast cancer显示文摘 | PRAT A PEROU C M | 2011 | Molecular Oncology2011，5，1： | 1 |
| 8 | Ultrasound-assisted extraction for rapid determination of Zn,Cu,Fe,Mg andMn in liver of diabetic rats under different antioxidant treatments显示文摘 | Prat M L Lopez-Gonzalvez A Ruiz M A | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，49，4： | 1 |
| 9 | Conserved MYC transcription factors play a key role in jasmonae signaling both in tomato and Arabidopsis显示文摘 | BOTER M RUIZ-RIVERO O ABDEEN A PRAT S | 2004 | Genes2004，18，： | 1 |
| 10 | Extracorporeal high2intensity focused ultrasound for VX2 liver tumors in the rabbit显示文摘 | Prat F Centarti M Sibille A | 1995 | Hepatology1995，21，3： | 1 |
| 11 | Prognostic significance ofprogesterone receptor- positive tumor cells withinimmunohistochemically defined luminal A breast cancer显示文摘 | Prat A Cheang MC Martin M | 2013 | J ClinOncol2013，31，2： | 1 |
| 12 | Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer显示文摘 | Prat A Cheang M C U Martín M | 2013 | J Clin Oncol2013，31，2： | 1 |
| 13 | Naturally occurring allele diversity allows potato cultivation in northern latitudes 显示文摘 | Kloosterman B Abelenda J A Gomez Mdel M Oortwijn M de Boer J M Kowitwanich K Horvath B M van Eck H J Smaczniak C Prat S Visser R G Baehem C W | 2013 | Nature2013，495，7440： | 1 |
| 14 | Extracorporeal high-intensity focused ultrasound for VX2 liver tumors in the rabbit显示文摘 | Prat F Centarti M Sibille A | 1995 | Hepatolo- gy1995，21，3： | 1 |
| 15 | Inducetion of a putative Ca2+ - ATPase mRNA in Nacl - adapted cells显示文摘 | Narasimhan M L Botella M A Chen Z | 1992 | Plant Physiol1992，100，： | 1 |
| 16 | Residue analysis of macrolides in poultry muscle by liquid chromatography-electrospray mass spectrometry显示文摘 | Codony R Compano R Granados M Garcia-Regueiro J A Prat M D | | 0，，： | 1 |
| 17 | Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer显示文摘 | Prat A Cheang MC Martin M | 2013 | J Clin Oncol2013，31，2： | 1 |
| 18 | Deconstructing the molecular portraits of breast cancer显示文摘 | Prat A Perou C M | 2011 | Mol Oncol2011，5，1： | 1 |
| 19 | Transcatheter aortic valve replace- ment : early results of the FRANCE ( FRench Aortic National CoreValve and Edwards) registry显示文摘 | Eltchaninoff H Prat A Gilard M | 2011 | Eur Heart J2011，32，2： | 1 |
| 20 | Intestinal perforation by foreign bodies显示文摘 | Pinero Madrona A Fermlndez Herndndez JA Carrasco Prats M | 2000 | Eur J Surg2000，166，4： | 1 |
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