|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer显示文摘AIM: To investigate the role of endothelial nitric oxide synthase-786 T > C promoter polymorphism in the etiology of gastric cancer(GC). METHODS: A total of 150 GC patients and 150 control subjects were included in the study. The information on demographic features was elicited with an informed consent from all the patients and control subjects using a structured questionnaire. Helicobacter pylori(H. pylori) infectivity status was tested in antral biopsies from all the subjects by rapid urease test following the method of Vaira et al. Genomic DNA was isolated from whole blood samples following the salting out method of Lahiri et al. Genotype analysis of the rs2070744 polymorphism was carried out by allele-specific polymerase chain reaction method. The genotypes were determined based on the appearance of bands on an agarose gel stained with ethidium bromide under ultraviolet gel documentation with the help of 100 bp ladder. Odds ratios and corresponding 95%CIs were determined using java stat online software. RESULTS: There was a significant difference in the distribution of C allele(C vs T; P = 0.000, OR = 5.038) in patient group compared to the control subjects exhibiting a fivefold increased risk for GC. When the T/T and C/C genotypes were compared, there was an enhanced GC risk for individuals with C/C genotype(T/T vs C/C; P = 0.000). Among the demographic factors, smoking and alcoholism were the common risk factors in patients compared to the control subjects(P < 0.05). Patients with smoking and alcoholism developed cancer even in heterozygous T/C condition(smoking: P = 0.020 and alcoholism: P = 0.005). Individuals with H. pylori infection showed seven fold increased risk for cancer. All the patients with C/C genotype revealed a significant association between H. pylori infection and GC. Among the patients 2.4% of them revealed familial incidence of GC. No significant difference was noticed between cases and controls with regard to consanguinity(P = 0.473).CONCLUSION: The Present data suggest that eN OS-786 C/C genotype and C allele may be considered as potential risk factors in patients with GC. | Devulapalli Krishnaveni Bhayal Amar Chand Porika Shravan Kumar Malladi Uma Devi Macherla Ramanna Akka Jyothy Nallari Pratibha N Balakrishna Ananthapur Venkateshwari | 2015 | World Journal of Gastrointestinal Oncology2015，7，7： | 2 |
| 2 | Mast cell stabilization,lipoxygenase inhibition,hyaluronidase inhibition,antihistaminic and antispasmodic activities of Aller-7,a novel botanical formulation for allergic rhinitis显示文摘 | Amit A Saxena VS Pratibha N | | 0，，： | 1 |
| 3 | Mast cell stabilization,lipoxygenase inhibition,hyaluronidase inhibition,antihistaminic and antispasmodic activities of Aller-7,a novel botanical formulation for allergic rhinitis显示文摘 | AMIT A SAXENA V S PRATIBHA N | 2003 | Drugs Exp Clin Res2003，29，： | 1 |
| 4 | Mast cell stabilization, li- poxygenase inhibition, hyaluronidase inhibition, antihistaminic and antispasmodic activities of Aller - 7, a novel botanical formulation for allergic rhinitis 显示文摘 | Amit A Saxena VS Pratibha N | 2003 | Drugs Exp Clin Res2003，29，： | 1 |
| 5 | Mast cell stabiliza- tion, lipoxygenase inhibition, hyaluronidase inhibition, anti- histaminic and antispasmodic activities of Aller-7, a novel botanical formulation for allergic rhinitis 显示文摘 | Amit A Saxena VS Pratibha N | 2003 | Drugs Exp Clin Res2003，29，3： | 1 |
| 6 | Estimation of paracetamol andlornoxicam by isocratic,gradient,and elevated temperature hplc using propylene carbonate显示文摘 | VARSHA N PRATIBHA V SONI M | 2014 | Liq Chromatogr Related Technol2014，37，8： | 1 |
| 7 | Morphometry of buccal mucosal cells in fluorosis: a new paradigm显示文摘 | Rao S M Sherlin H J Anuja N Pratibha R Priya P Chandrasekar T | 2011 | Hum Exp Toxicol2011，30，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员