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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Prolonged remission from eltrombopag in chronic refractory idiopathic thrombocytopenic purpura显示文摘 | Noronha V Philip SD Joshi A | 2012 | Int J Hematol2012，96，3： | 1 |
| 3 | Clonal propagation of Vanilla planifolia (Sslisb) Ames using tissue culture显示文摘 | Philip V J Nainar A Z | 1986 | J Plant Physiol1986，122，： | 1 |
| 4 | High-performance high-speed steels by design显示文摘 | Steven G Nehrenberg A E Philip T V | 1964 | Trans ASM1964，57，64： | 1 |
| 5 | End-stage renal disease and economic incentives:The international study of health care organization and fi- nancing显示文摘 | AviDor Mark V Pauly Margaret A Eichleay Philip J Held | 2007 | International Journal of Health Care Finance and Economics2007，，2： | 1 |
| 6 | Recursive temporal denoising and motion estimation in video显示文摘 | ZLOKOLICA V PIITIRICA A PHILIPS W | 2004 | IEEE2004，3，： | 1 |
| 7 | The antibiotic activity of the lac- toperoxidase-thiocyanate-hydrogen peroxide system in the calf ab- sorption of nutrients in the pig显示文摘 | Reiter A A Marshal V M Philips S M | 1980 | Res Vet Sci1980，28，： | 1 |
| 8 | The growth of Mg(OH)2 crystals from MgCl2 and Ca(OH)2 in a brine environment显示文摘 | Philips V A Kolbe J L Opperharser H | 1997 | Journal of Crystal Growth1997，41，： | 1 |
| 9 | Investigation of the attachment of Thiobacillus ferrooxidans to mineral sulfides using scanning elctron microscopy analysis显示文摘 | SAMPSON M L PHILIPS C V BALL A S | 2000 | Minerals Engineering2000，13，： | 1 |
| 10 | Hybrid block replacementheterogeneous component lives 显示文摘 | Philip A S Cristiano A V C | 2010 | European Journal ofOperational Research2010，206，2： | 1 |
| 11 | Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts显示文摘 | Philips A Roux P Coulon V | 2000 | J Biol Chem2000，275，8： | 1 |
| 12 | Effect of pH on the growth of Mg(OH)2 crystals in an aqueous environment at 60℃显示文摘 | PHILIPS V A KOLBE J L OPPERHAUSER H | 1977 | Crystal Growth1977，41，： | 1 |
| 13 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 14 | The growth of Mg(OH)2 crystals from MgCl2 and Ca(OH)2 in a brine environment显示文摘 | Philips V A Kobe J L Opperharser H | 1997 | Journal of Crystal Growth1997，41，： | 1 |
| 15 | Directly heated high surface area so!id phase microextraction sampler for rapid field forensic analyses显示文摘 | SCOTY A R ROBERT V M PHILIP A S | 2009 | Analytical Chemistry2009，81，21： | 1 |
| 16 | Phase Ⅱ study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma显示文摘 | Philip P A Zalupski M M Vaitkevicius V K | 2001 | Cancer2001，92，3： | 1 |
| 17 | Randomized, placebocontrolled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis 显示文摘 | Guruprasad P James A Philip V | 2008 | Gastroenterology2008，135，4： | 1 |
| 18 | Investigation of anode and cathode jets influence on electric arc properties with current up to 500 kA 显示文摘 | PHILIP G R ALEXANDER A B ALEXANDER V B | 2003 | IEEE Transaction on Plasma Science2003，31，2： | 1 |
| 19 | Cortisol is necessary for seawater tolerance in larvae of a marine teleost the summer flounder显示文摘 | PHILIP A V MARICRUZ M NEIL D M | 2007 | General and Comparative Endocrinology2007，151，1： | 1 |
| 20 | Microbial community structure in the North Pacific ocean 显示文摘 | Brown M V Philip G K Bunge J A | 2009 | The ISME Journal2009，3，12： | 1 |
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