|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 2 | The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration显示文摘 | Gurniak C B Perlas E Witke W | 2005 | Dev Biol2005，278，1： | 1 |
| 3 | Feasibility and efficacy of ultrasound-guided block of the saphenous nerve in the adductor canal显示文摘 | Manickam B Perlas A Duggan E | 2009 | Reg Anesth Pain Med2009，34，6： | 1 |
| 4 | Epileptic seizures as a cause of unilateral pulmonary edema 显示文摘 | Koppel B S Pearl M Perla E | 1987 | Epilepsia1987，28，1： | 1 |
| 5 | Evaluation of traumatic brain injury: brain potentials in diagnosis, function, and rognosis 显示文摘 | DUNCAN CC SUMMERS AC PERLA E J | 2011 | Int J Psychophysiol2011，82，1： | 1 |
| 6 | Minimum effective volume d local anesthetic for ultrasound - guided supraclavicular brachial plexus block 显示文摘 | Duggam E El Beheiry H Perlas A | 2009 | Reg Anesth Pain Med2009，34，3： | 1 |
| 7 | Characterization of gonadal sex cord - stromal tumor cell line from inhibin - alpha and p53 - deftcient mice:the role of activin al an aautocrine growth factor显示文摘 | Shikone T Matzuk MM Perlas E | 1994 | Mol Endocrionol1994，8，8： | 1 |
| 8 | Follow up after a family based genetic screening programme for familial hypercholesterolaemia: is screening alone enough? 显示文摘 | Merel C van Maarle Marlies E A Stouthard Perla J Marang-van de Mheen | 2002 | BMJ2002，324，： | 1 |
| 9 | Utilization of Feed Pea, Pisum Sativum, Meal as a Protein Source in Practical Diets for Juvenile Tiger Shrimp, Penaeus Monodon 显示文摘 | Myrna N Bautista T Perla S E | 2003 | Aquaculture2003，，225： | 1 |
| 10 | Cystine knot of the gonadotropin alpha subunit is critical for intracellular behavior but not for in zitro biological activity显示文摘 | Sato A Perlas E Menahem D B | 1997 | J Biol Chem1997，272，18： | 1 |
| 11 | Characterization of gonadal sex cord-tromal tumor cell line from inhibin-alpha and p53-deficient mice:the role of activin al an aautocrine growth factor显示文摘 | Shikone T Matzuk MM Perlas E | 1994 | Mol Endocrionol1994，8，8： | 1 |
| 12 | Parent materials, buried soils and fragipans in northwestern Buenos Aires Province, Argentina 显示文摘 | PERLA A I JORGE E G | 1998 | Quaternary International1998，5152，： | 1 |
| 13 | A theory of snow slab failure 显示文摘 | Perla R Lachapelle E | 1970 | Journalof Geophysics research1970，75，： | 1 |
| 14 | Follicle-stimulating hormone enhances the development of preantral follicles in juvenile rats显示文摘 | McGEE E A PERLAS E LAPOLT P S | 1997 | Biol Reprod1997，57，5： | 1 |
| 15 | Characterization of gonadal sex cord-stromal tumor cell line from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor显示文摘 | Shikone T Matzuk MM Perlas E | 1994 | Mol Endocrionol1994，8，8： | 1 |
| 16 | Ecological footprint of the national capital region households: Bridging the gap between nutrition and environment显示文摘 | Serafico M E Espinoza M M Perlas L A | 2012 | Philippine Journal of Science2012，141，1： | 1 |
| 17 | Identification of novel peptide hormones in the human proteome by hidden Markov model screening显示文摘 | MIRABEAU O PERLAS E SEVERINI C | 2007 | Genome Res2007，17，3： | 1 |
| 18 | Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor 显示文摘 | Shikone T Matzuk MM Perlas E | 1994 | Mol Endocrinol1994，8，： | 1 |
| 19 | Characterization of gonadal sex cord-stromal tumor cell line from inhibin-alpha and p53-deficient mic:the role of activin as an autocrine growth factor显示文摘 | Shikone T Matzuk MM Perlas E | 1994 | MolEndocrionol1994，8，8： | 1 |
| 20 | Identification of novel peptide hormones in the human proteome by hidden Markov model screening 显示文摘 | Mirabeau O Perlas E Severini C | 2007 | Genome Res2007，17，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员