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55篇 您的检索式:作者名="PERELMAN M"
    题名 作者 年代 出处 被引量
1白细胞介素-13刺激大鼠气道黏液高分泌的分子机制显示文摘目的研究白细胞介素-13(IL-13)在体内对支气管/肺黏液分泌的作用并探讨其作用机制。方法所有SD大鼠被随机分为IL-13组、对照组和IL-13 plus SP600125组。Western检测大鼠支气管/肺组织黏蛋白(MUC)5AC,磷酸化细胞外信号调节激酶1/2(p-ERK1/2)和磷酸化c-Jun氨基端激酶1/2(p-JNK1/2)的表达变化,RT-PCR检测大鼠支气管/肺组织STAT4和STAT6 mRNA表达水平。EMSA检测通路下游作用因子FOXA2和激活蛋白1的表达。结果同对照组相比,IL-13刺激10 h后大鼠支气管/肺组织MUC5AC和p-JNK1/2表达升高,而p-ERK1/2表达无显著变化;使用SP600125阻断JNK通路表达后,MUC5AC表达减弱;IL-13刺激10 h后大鼠支气管/肺组织STAT4 mRNA表达无显著变化,STAT6 mRNA表达显著升高,EMSA提示IL-13刺激后大鼠支气管/肺组织FOXA2结合活性显著降低,而激活蛋白1结合活性没有明显变化。结论 IL-13能够刺激大鼠支气管/肺组织黏液分泌,其作用机制可能是通过调控STAT6-FOXA2信号通路。江德鹏 Victor P Kolosov Juliy M Perelman 周向东 2011南方医科大学学报2011,31,1:2
2The expression of three genes in primary non-small celt lung cancer is associated with metastatic spread to the brain显示文摘Grinberg-Rashi H Ofek E Perelman M 2009Clin Cancer Res2009,15,5:1
3Detection of preinvasive cancer cells 显示文摘Backman V Wallace M B Perelman L T 2000Nature2000,406,:1
4Disorders of orgasm and ejaculation in men显示文摘McMahon CG Abdo C Incrocci L Perelman M Rowland D Waldinger M Xin ZC 2004Sex Med2004,1,1:1
5Platelet-acti- vating factor, PAF acetylhydrolase, and severe ana- phylaxis显示文摘Vadas P Gold M Perelman B 2008N Engl J Med2008,358,1:1
6Surgery for pulmonary tuberculosis显示文摘Perelman M Strelzov V P 1997World J Surg1997,21,:1
7Self-reported premature ejaculation and aspects of sexual functioning and satisfaction显示文摘Rowland D Perelman M Althof S 2004J Sex Med2004,1,2:1
8Relationship between the severity of experimental diabetes and altered lung phospholipid metabolism 显示文摘Engle M J Perelman R H McMahon K E 1984Prec Soc Exp Biol Med1984,176,:1
9Self-reported premature ejaculation and aspects of sexual functioning and satisfaction 显示文摘Rowland D Perelman M Althof S 2004J Sex Med2004,1,2:1
10The medial instep plantar faseiotomy显示文摘Perelman G K Figura M A Sandberg N S 1995Foot Ankle Surg1995,34,:1
11From bloodless surgery to patient blood management显示文摘Shander A Javidroozi M Perelman S 2012Mt Sinai J Med2012,79,1:1
12Platelet - activating factor, PAF acetylhydrolase, and severe anaphylaxis 显示文摘Vadas P Gold M Perelman B 2008New England Jour- nal of Medicine2008,358,1:1
13The medial instep plantart fasciotomy显示文摘PERELMAN G K FIGURA M A SANDBERG W S 1995J Foot Ankle Surg1995,34,5:1
14Computational Fluid Dynamics Simulation of Coal-fired Utility Boilers: an Engineering Tool显示文摘KORYTNYI E SAVELIEV R PERELMAN M 2009Fuel2009,88,1:1
15Using SimPoint for accurate and efficient simulation 显示文摘PERELMAN E HAMERLY G BIESBROUCK M V 2003ACM SIGMETRICS Performance Evaluation Review2003,31,1:1
16Syringomatous adenoma of the nipple; a ease report显示文摘Yosepovich A Perelman M Ayalon S 2005Pathol Res Pract2005,201,5:1
17Syringomatous adenoma of the nipple: a case report显示文摘Yosepovich A Perelman M Ayalon S 2005Pathol Res Pract2005,201,5:1
18Platelet-activating factor,PAF acetylhydrolase,and severe anaphylaxis显示文摘Vadas P Gold M Perelman B 0,,1:1
19Transient neonatal myasthenia gravis revealing a myasthenia gravis and a systemic lupus erythematosus in the mother:case report and review of the literature显示文摘Saint-Faust M Perelman S Dupont D 2010Am J Perinatol2010,27,2:1
20Natural antioxidant activity in some microalgal species显示文摘Perelman A Matsukawa R Schlosberg M 1998Israel Journal of Plant Sciences1998,46,2:1
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