|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Regulative effect of Taohong Siwu decoction(桃红四物汤) on extracellular matrix of endometrium in drug-induced abortion显示文摘OBJECTIVE: To explore the effects of Taohong Siwu decoction(桃红四物汤, THSWD) on the extracellular matrix of endometrium in rats following drug-induced abortion.METHODS: Thirty-six pregnant female rats were administered mifepristone and misoprostol to induce abortion, and amounts of uterine bleeding were recorded. Pathological damage and collagen accumulation were detected by hematoxylin-eosin staining and Masson’s trichrome staining in uterus, respectively. Myeloperoxidase was evaluated by immunohistochemistry.The expression levels of fibronectin, laminin, matrix metalloproteinase 9(MMP-9), and tissue inhibitor of metalloproteinase 1(TIMP-1) were quantified using western blotting.RESULTS: THSWD could promote endometrial protection in rats following drug-induced abortion.The contents of cellulose and myeloperoxidase were significantly decreased in uterine tissue of THSWD-treated groups. Moreover, THSWD significantly decreased the expression levels of fibronectin, laminin, and TIMP-1. THSWD also significantly increased MMP-9 expression and the MMP-9/TIMP-1 ratio.CONCLUSION: THSWD plays a critical role in endometrial protection by reducing extracellular matrix deposition and uterine fibrosis. These effects may have been achieved by increasing MMP-9, reducing TIMP-1, and/or altering the ratio of MMP-9/TIMP-1. | WANG Mengmeng GUO Dongdong HAN Lan PENG Daiyin CHEN Weidong ZHANG Yanyan | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 5 |
| 2 | Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice显示文摘Alveolar epithelial cells(AECs)injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding and subsequent pulmonary fibrosis(PF).Nevertheless,the exact mechanisms regulating the regeneration of AECs post-injury still remain unclear.SMARCA4 is a part of the large ATP-dependent chromatin remodelling complex SWI/SNF,which is essential for kidney and heart fibrosis.We investigates SMARCA4 function in lung fibrosis by establishing PF mice model with bleomycin firstly and found that the expression of SMARCA4 was mainly enhanced in alveolar type II(ATII)cells.Moreover,we established an alveolar epithelium-specific SMARCA4-deleted SP-C-rtTA/(tetO)7-Cre/SMARCA4f/f mice(SOSM4D/D)model,as well as a new SMARCA4-deleted alveolar type II(ATII)-like mle-12 cell line.We found that the bleomycin-induced PF was more aggressive in SOSM4D/D mice.Also,the proliferation of ATII cells was decreased with the loss of SMARCA4 in vivo and in vitro.In addition,we observed increased proliferation of ATII cells accompanied by abnormally high expression of SMARCA4 in human PF lung sections.These data uncovered the indispensable role of SMARCA4 in the proliferation of ATII cells,which might affect the progression of PF. | Danyi Peng Daozhu Si Rong Zhang Jiang Liu Hao Gou Yunqiu Xia Daiyin Tian Jihong Dai Ke Yang Enmei Liu Yujun Shi Q.Richard Lu Lin Zou Zhou Fu | 2017 | Genes & Diseases2017，4，4： | 3 |
| 3 | Predicting the Potential Distribution of Rubia cordifolia L.in China显示文摘[Objectives]We intend to conduct a study to predict habitat suitability and geographic distribution of Rubia cordifolia L.,to find the most suitable ecological environment for its growth,and to provide a theoretical basis for the development and cultivation of R.cordifolia L.industry.[Methods]Based on the environmental factors and the occurrence data,we predicted the potential geographic distribution of R.cordifolia L.in China by combining the MaxEnt model and ArcGIS.[Results]The training set and test set AUC were respectively 0.963 and 0.946,indicating that the MaxEnt model predicted well.The wettest monthly precipitation,precipitation in July,precipitation of driest season,and average monthly temperature in September and April were the dominant environmental factors affecting the distribution of R.cordifolia L.The highly habitable areas were mainly concentrated in central,eastern and northern China.[Conclusions]The results of this study can be used as a reference for the development of R.cordifolia L.industry in related areas. | Wei QIN Suping JIANG Xueke ZHANG Dingkang CHEN Shoujin LIU Daiyin PENG | 2021 | Medicinal Plant2021，12，3： | 2 |
| 4 | TSC1 enables plastid development under dark conditions, contributing to rice adaptation to transplantation shock显示文摘Since its domestication from wild rice thousands of years ago, rice has been cultivated largely through transplantation. During transplantation from the nursery to the paddy field, rice seedlings experience transplantation shock which affects their physiology and production.However, the mechanisms underlying transplantation shock and rice adaptation to this shock are largely unknown. Here,we isolated a transplant-sensitive chloroplast-deficient(tsc_1)rice mutant that produces albino leaves after transplantation.Blocking light from reaching the juvenile leaves and leaf primordia caused chloroplast deficiencies in transplanted tsc_1 seedlings. TSC_1 encodes a noncanonical adenosine triphosphate-binding cassette(ABC) transporter homologous to At NAP_(14) and is of cyanobacterial origin. We demonstrate that TSC_1 controls plastid development in rice under dark conditions, and functions independently of light signaling.However, light rescued the tsc_1 mutant phenotype in a spectrum-independent manner. TSC_1 was upregulated following transplantation, and modulated the iron and copper levels, thereby regulating prolamellar body formation during the early P_4 stage of leaf development. Therefore, TSC_1 is indispensable for plastid development in the absence of light,and contributes to adaptation to transplantation shock.Our study provides insight into the regulation of plastid development and establishes a framework for improving recovery from transplantation shock in rice. | Xiaoliang Shi Sunlu Chen Yu Peng Yufeng Wang Jiugeng Chen Zhanghua Hu Baohe Wang Aihong Li Daiyin Chao Yuhong Li Sheng Teng | 2018 | Journal of Integrative Plant Biology2018，60，2： | 2 |
| 5 | Structure and mechanism of a group-I cobalt energy coupling factor transporter显示文摘联合精力的因素(ECF ) transporters 是最近在微生物识别的 ATP 有约束力的盒子 transporters 的一个大家庭。为从环境的微量元素举起负责, ECF transporters 是由膜底层绑定部件 EcfS 和由不可分的膜支架部件 EcfT 和二细胞质的 ATP 绑定 / 水解作用的部件 EcfA/A 组成的一个 ECF 模块组成的模块化的 transporters。ECF transporters 被分类进组我和 II。当前,组的分子的理解 -- 我 ECF transporters 很被限制,部分由于 transporter 的缺乏复杂结构的信息。这里,我们现在的结构和这个组的基于结构的分析 -- 我钴 ECF transporter CbiMNQO,谁的组成的子单元 CbiM/CbiN, CbiQ,和 CbiO 分别地对应于 group-II ECF transporters 的 EcfS, EcfT,和 EcfA 部件。通过不同 CbiMNQO 子单元的宪法和相关 ATPase 和 transporter 活动的决心,底层绑定子单元 CbiM 被发现刺激 CbiQOs 基础 ATPase 活动。CbiMQO 建筑群的结构在它的里面打开符合构造和 CbiO 的被决定在, -methyleneadenosine 第 5-triphosphate-bou 关上的符合构造。基于结构的分析揭示了在不同部件, CbiM 的 L1 循环的底层门函数,和 ATP 绑定和产品版本在 CbiMNQO transporter 建筑群以内导致的 CbiO 的 conformational 变化之间的相互作用。这些调查结果使我们能建议 CbiMNQO transporter,运输过程在要求旋转的一个工作模型或倒下 CbiQ 和 CbiM,和在联合 conformational 的 CbiN 力量功能在 CbiQ 和 CbiM 之间变化。 | Zhihao Bao Xiaofeng Qi Sen Hong Ke Xu Fangyuan He Minhua Zhang Jiugeng Chen Daiyin Chao Wei Zhao Dianfan Li Jiawei Wang Peng Zhang | 2017 | Cell Research2017，27，5： | 1 |
| 6 | Taohong Siwu decoction(桃红四物汤)ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor-κB signal pathway显示文摘OBJECTIVE:To investigate the effect of Taohong Siwu decoction(桃红四物汤,TSD)on atherosclerosis in rats as well as investigate the underlying mechanism based on molecular docking.METHODS:Sixty healthy male Sprague-Dawley rats were randomly divided into 6 groups with 10 rats in each group:control group,model group,atorvastatin group(AT,2.0 mg/kg),and TSD groups(20,10,5 g/kg)after 7 d of acclimation.The model of atherosclerosis was successfully established except the control group by high fat diet(HFD)and vitamin D2.Biochemical analyzers were used to detect the levels of triglyceride(TG),total cholestero(TC),low density lipoprotein-cholesterol(LDLC)and high density lipid-cholesterol(HDL-C)in blood lipid.The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-1β(IL-1β)were determined by enzyme-linked immunosorbent assay.Sudan IV staining and Hematoxylin and eosin staining(HE staining)were performed to observe the pathological changes in aortic tissue.Molecular docking technology was used to predict the best matching between the main components of TSD and the target proteins.The expression of target proteins was further detected by quantitative real time polymerase chain reaction(q RTPCR)and Western blot analysis.RESULTS:The results showed that TSD restricted atherosclerosis development and decreased the inflammatory cytokines in plasma.Molecular docking results predicted that the main components of TSD showed a strong binding ability with toll-like receptor(TLR4),myeloid differentiation primary response protein 88(My D88),and nuclear factor kappa-B(NF-κB).The results of q RT-PCR and Western blot analysis showed that the m RNA and protein expressions of TLR4,My D88 and NF-κB p65 in the aorta were reduced in atorvastatin group and TSD group.CONCLUSIONS:TSD can ameliorate atherosclerosis in rats,and the underlying mechanism is supposed be related to the suppression of inflammatory response by regulating TLR4/My D88/NF-κB signal pathway. | CHANG Fengjin ZHOU Peng LI Guoying ZHANG Weizhi ZHANG Yanyan PENG Daiyin CHEN Guangliang | 2024 | Journal of Traditional Chinese Medicine2024，44，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员