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| 1 | Asymptomatic ca- rotid disease-a new tool for assessing neurological risk 显示文摘 | Pedro LM Sanches JM Seabra J | 2014 | Echocardiography2014，31，3： | 1 |
| 2 | Effect of the hepatitis B virus HB x protein on integrin-mediated adhesion to and migration on extracellular matrix 显示文摘 | Pedro LM Maria YM | 2001 | J Hepatol2001，34，3： | 1 |
| 3 | Computer-assisted carotid plaque analysis:characteristics of plaques associated with cerebrovascular symptoms and cerebral infarction显示文摘 | PEDRO LM PEDRO MM GONCALVES I | 2000 | Eur J Vasc Endovasc Surg2000，19，2： | 1 |
| 4 | Computer-assisted carotid plaque analysis:characteristics of plaques associated with cerebrovascular symptoms and cerebral infarction显示文摘 | Pedro LM Pedro MM Goncalves I | 2000 | Eur J Vasc Endovasc Surg2000，19，2： | 1 |
| 5 | Ultrasonographic risk score of carotid plaques显示文摘 | Fernandes J Pedro MM | 2002 | Eur J Vasc Endovasc Surg2002，24，： | 1 |
| 6 | A bovine pericardium rigid prosthesis for left ventricle restoration : 12 years of follow-up 显示文摘 | SILVEIRA FILHO LM PETRUCCI O VILARINHO KA BAK- ER RS GARCIA F OLWEIRA PEDRO PM | 2011 | Rev Bras Cir Cardiovase2011，26，2： | 1 |
| 7 | Ult rasonographic risk score of carotid plaques显示文摘 | Pedro LM Fernandes J Pedro MM | 2002 | Eur J Vasc Endovasc Surg2002，24，6： | 1 |
| 8 | A 3-D Ultrasound-based Framework to Characterize the Echo Morphology of Carotid Plaques显示文摘 | Seabra JC Pedro LM e Fernandes JF | 2009 | IEEE Trans Biomed Eng (S0018-9294)2009，56，5： | 1 |
| 9 | Computer-assisted carotid plaque analysis: characteristics of plaques associated with cerebrovascular symptoms and cerebral infarction 显示文摘 | Pedro LM Pedro MM Goncalves I | 2001 | Eur J Vasc Endovasc Surg2001，19，： | 1 |
| 10 | Inhibition of macrophage migration inhi- bitory factor decreases proliferation and cytokine expression in bladder cancer cells 显示文摘 | Katherine LM Pedro LV Erica CL | 2004 | BMC Cancer2004，4，1： | 1 |
| 11 | Ultrasonographic risk score of carotid plaques显示文摘 | Pedro LM Fernandes J Pedro MM | 2002 | Eur J Vasc Endovasc Surg2002，24，： | 1 |
| 12 | Takayasu arteritis presenting with internal carotid artery dissection显示文摘 | Geraldes R Batista P Pedro LM | | 0，，： | 1 |
| 13 | Septic shock 3.0 criteria application in severe COVID-19 patients:An unattended sepsis population with high mortality risk显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)can be associated with life-threatening organ dysfunction due to septic shock,frequently requiring intensive care unit(ICU)admission,respi-ratory and vasopressor support.There-fore,clear clinical criteria are pivotal for early recognition of patients more likely to need prompt organ support.Although most patients with severe COVID-19 meet the Sepsis-3.0 criteria for septic shock,it has been increasingly recognized that hyperlactatemia is frequently absent,possibly leading to an underestimation of illness severity and mortality risk.AIM To identify the proportion of severe COVID-19 patients with vasopressor support requirements,with and without hyperlactatemia,and describe their clinical outcomes and mortality METHODS We performed a single-center prospective cohort study.All adult patients admitted to the ICU with COVID-19 were included in the analysis and were further divided into three groups:Sepsis group,without both criteria;Vasoplegic Shock group,with persistent hypotension and vasopressor support without hyperlactatemia;and Septic Shock 3.0 group,with both criteria.COVID-19 was diagnosed using clinical and radiologic criteria with a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)positive RT-PCR test.RESULTS 118 patients(mean age 63 years,87%males)were included in the analysis(n=51 Sepsis group,n=26 Vasoplegic Shock group,and n=41 Septic Shock 3.0 group).SOFA score at ICU admission and ICU length of stay were different between the groups(P<0.001).Mortality was significantly higher in the Vasoplegic Shock and Septic Shock 3.0 groups when compared with the Sepsis group(P<0.001)without a significant difference between the former two groups(P=0.713).The log rank tests of Kaplan-Meier survival curves were also different(P=0.007).Ventilator-free days and vasopressor-free days were different between the Sepsis vs Vasoplegic Shock and Septic Shock 3.0 groups(both P<0.001),and similar in the last two groups(P=0.128 and P=0.133,respectively).Logistic regression identified the maximum dose of vasopressor therapy used(AOR 1.046;95%CI:1.012-1.082,P=0.008)and serum lactate level(AOR 1.542;95%CI:1.055-2.255,P=0.02)as the major explanatory variables of mortality rates(R20.79).CONCLUSION In severe COVID-19 patients,the Sepsis 3.0 criteria of septic shock may exclude approximately one third of patients with a similarly high risk of a poor outcome and mortality rate,which should be equally addressed. | JoséPedro Cidade LM Coelho Vasco Costa Rui Morais Patrícia Moniz Luís Morais Pedro Fidalgo António Tralhão Carolina Paulino David Nora Bernardino Valério Vítor Mendes Camila Tapadinhas Pedro Povoa | 2022 | World Journal of Critical Care Medicine2022，11，4： | 0 |
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