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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors显示文摘 | Martyn E. Caplin Marianne Pavel Jaros?aw B. ?wik?a Alexandria T. Phan Markus Raderer Eva Sedlá?ková Guillaume Cadiot Edward M. Wolin Jaume Capdevila Lucy Wall Guido Rindi Alison Langley Séverine Martinez Jo?lle Blumberg Philippe Ruszniewski | 2014 | The New England Journal of Medicine2014，，： | 3 |
| 3 | Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes显示文摘AIM To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contributes to lipodystrophy syndrome. METHODS Preadipocytes from healthy donors were assessed for proliferation and differentiation in the presence of nucleoside reverse transcriptase inhibitors(NRTIs), nonnucleoside reverse transcriptase inhibitors(NNRTIs), and protease inhibitors(PIs) individually and in combination. Effects on proliferation were assessed with a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay and effects on differentiation were assessed from glycerol-3-phosphate dehydrogenase(GPDH) activity and quantitation of Oil Red O staining for intracellular lipid. Data were analyzed with a randomized block ANOVA with post-hoc Fisher's Least Significant Difference test. RESULTS Preadipocyte proliferation was inhibited by a combination of NNRTI + NRTI(14% at 48 h, P < 0.001) and PI + NRTI(19% at 48 h, P < 0.001) with additional suppression when ritonavir(RTV) was added(26% at 48 h). The drug combination of atazanavir(ATV) + RTV + emtricitabine(FTC) + tenofovir(TDF) had the greatest inhibitory effect on proliferation at 48 h. Preadipocyte differentiation was most significantly reduced by the efavirenz + FTC + TDF assessed either by GPDH activity(64%) or lipid accumulation(39%), P < 0.001. Combining NRTIs with a PI(ATV + FTC + TDF) significantly suppressed differentiation(GPDH activity reduced 29%, lipid accumulation reduced by 19%, P < 0.01). This effect was slightly greater when a boosting amount of RTV was added(ATV + FTC + TDF + RTV, P < 0.001). CONCLUSION Although combination antiretroviral therapy is clinically more efficacious than single drug regimens, it also has a much greater inhibitory effect on preadipocyte proliferation and differentiation. | Eyone Jones Pavel Mazirka Margaret A McNurlan Frank Darras Marie C Gelato Giuseppe Caso | 2017 | World Journal of Virology2017，6，3： | 3 |
| 4 | Reverse micellar synthesis of a nanoparticle/polymer composite 显示文摘 | Pavel F M Mackay R A | 2000 | Langmuir2000，16，23： | 1 |
| 5 | A study on the PAPR Reduction by Hybrid Algorithm Based on the PTS and SIaM Techniques显示文摘 | Pavel A Pushkarev KW Ryu | 2003 | IEEE20032003，2003，： | 1 |
| 6 | Finding composite regulatory patterns in DNA sequences 显示文摘 | Eleazar Eskin Pavel A Pwvzner | 2002 | Bioinformatics2002，18，1： | 1 |
| 7 | ENETS consensus guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary 显示文摘 | Pavel M Baudin E Couvelard A | 2012 | Neuroendocrinol- ogy2012，95，2： | 1 |
| 8 | DIAL-infrared lidar for monitoring of main pipelines and gas industry objects 显示文摘 | Pavel G Philippov Yurij A Bakhirkin Victor N Moiseev | 1998 | SPIE1998，，3504： | 1 |
| 9 | Overview of support effects in bydrotreating catalysts显示文摘 | MICH LE B PAVEL A CHRISTOPHE G | 2003 | Catalysis Today2003，86，14： | 1 |
| 10 | Chemically Patterned Microspheres for Controlled Nanoparticle Assembly in the Construction of SERS Hot Spots 显示文摘 | BRAUN G PAVEL I MORRILL A R et at | 2007 | J Am Chem Soc2007，129，： | 1 |
| 11 | An Experimental and Numerical Study on Heat Transfer Enhancement for Gas Heat Exchangers Fitted with Porous Media 显示文摘 | Pavel B I Mohamad A A | 2004 | International Journal of Heat and Mass Transfer2004，47，23： | 1 |
| 12 | New alternating copolyimides by high temperature synthesis in benzoic acid medium显示文摘 | Alexander A K Marina Y Y Pavel V B | 2004 | High Performance Poly?mers2004，16，： | 1 |
| 13 | 显示文摘 | Pavel A | 2005 | Journal of Magnetism and Magnetic Materials2005，289，： | 1 |
| 14 | An experimental and numeri- cal study on heat transfer enhancement for gas heat ex- changers fitted with porous media 显示文摘 | Pavel B I Mohamad A A | 2004 | International Journal of Heat and Mass Transfer2004，47，23： | 1 |
| 15 | Molecular genetic alterations of FH1T and p53 genes in benign and malignant thyroid gland lesions 显示文摘 | PAVELIC K DEDIVITIS R A K APITANOVIC S | 2006 | Mulat Res2006，599，： | 1 |
| 16 | Resonant transformation of modes in oversize electrodynamic systems 显示文摘 | Malygin S A Pavel'ev V G Tsimring S E | 1983 | Radiophysics and Quantum Electronics1983，26，9： | 1 |
| 17 | Coupled resonator gyrotrons with mode conversion显示文摘 | Zapevalov V E Malygin S A Pavel'ev V G | 1984 | Radiophys Quantum Electron1984，27，： | 1 |
| 18 | Reverse micellar synthesis of a nanoparticle/polymer composite 显示文摘 | Pavel F M Mackay R A | 2000 | Langmuir2000，16，23： | 1 |
| 19 | Steady-state and transient characterises of 10 kV 4H-SiC diodes显示文摘 | Mnatsakanov Tigran T Ivanov Pavel A | 2004 | Solid-state Electonics2004，48，： | 1 |
| 20 | Increased Angioten- sin 11 AT: receptor mRNA and binding in spleen andlung of ATz receptor gene disrupted mice显示文摘 | Pavel J Terr6n J A Benicky J | 2009 | Regul Pept2009，158，13： | 1 |
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