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| 1 | Comprehensive management of full-thickness luminal defects: The next frontier of gastrointestinal endoscopy显示文摘Full thickness gastrointestinal defects such as perforations, leaks, and fistulae are a relatively common result of many of the endoscopic and surgical procedures performed in modern health care. As the number of these procedures increases, so too will the number of resultant defects. Historically, these were all treated by open surgical means with the associated morbidity and mortality. With the recent advent of advanced endoscopic techniques, these defects can be treated definitively while avoiding an open surgical procedure. Here we explore the various techniques and tools that are currently available for the treatment of gastrointestinal defects including through the scope clips, endoscopic suturing devices, over the scope clips, sealants, endoluminal stents, endoscopic suction devices, and fistula plugs. As fistulae represent the most recalcitrant of defects, we focus this editorial on a multimodal approach of treatment. This includes optimization of nutrition, treatment of infection, ablation of tracts, removal of foreign bodies, and treatment of distal obstructions. We believe that by addressing all of these factors at the time of attempted closure, the patient is optimized and has the best chance at longterm closure. However, even with all of these factors addressed, failure does occur and in those cases, endoscopic therapies may still play a role in that they allow the patient to avoid a definitive surgical therapy for a time while nutrition is optimized, and infections are addressed. | Joshua S Winder Eric M Pauli | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，8： | 13 |
| 2 | Contemporary classification of histiocytic disorders: the WHO Committee on histiocytic/ retieulum cell proliferations, Reclassification Working Group of the Histiocyte Society 显示文摘 | Favara BE Feller AC Pauli M etal | 1997 | Med Pediatr Oncol1997，29，3： | 1 |
| 3 | Acute renal infarction:Clinical characteristics of 17 patients显示文摘 | Domanovits H Paulis M Nikfardjam M | 1999 | Medicine (Baltimore)1999，78，6： | 1 |
| 4 | Evaluating evidence-based medicine skills during a performance-based examination显示文摘 | Davidson ra Duerson M Romrell L Pauly R Watson rt | 2004 | Acad Med2004，79，3： | 1 |
| 5 | Sparse MRI:the application of compressed sensing for rapid MR imaging显示文摘 | Lustig M Donoho D Pauly JM | 2007 | Magn Reson Med2007，58，6： | 1 |
| 6 | Multi-scale feature extraction on point-sampled surfaces 显示文摘 | PAULY M KEISER R GROSS M | 2003 | Computer Graphics Forum2003，22，3： | 1 |
| 7 | The not -for -profit hospital as a physician's cooperative 显示文摘 | Pauly M Redisch M | 1973 | The America Economic Re- view1973，63，1： | 1 |
| 8 | Gas sensitivity of phthalocynine thin film显示文摘 | Maleysson C Pauly A | 1994 | Sensors and Actuators1994，19，13： | 1 |
| 9 | Classical swine fever virus:independent induction of protective immunity by two structural proteins 显示文摘 | K(o)nig M Lengsfeld T Pauly T | 1995 | J Virol1995，69，： | 1 |
| 10 | Preparation and characterization of nibium oxide for the catalytic aldol condensation of acetone 显示文摘 | PAULIS M MARTIN M SORIA D B | 1999 | Applied Catalysis A:General1999，180，12： | 1 |
| 11 | ,Tunable magneticproperties of nanoparticle two - dimensional assemblies ad-dressed by mixed self - assembled monolayers 显示文摘 | Pichon B P Pauly M Marie P | 2011 | Lang-muir2011，27，10： | 1 |
| 12 | Nonlinear phase correction for navigated diffusion imaging 显示文摘 | MILLER K L PAULY J M | 2003 | Magn Reson Med2003，50，2： | 1 |
| 13 | Example-Based Facial Rigging显示文摘 | Li H Weise T Pauly M | 2010 | ACM Transaction on Graphics2010，29，4： | 1 |
| 14 | Reassessing the environmental Kuznets curve for CO2 emission: a robustness exercise显示文摘 | Galeotti M Lanza A Pauli F | 2006 | Ecological Eco- nomics2006，57，1： | 1 |
| 15 | Classical swine fever virus: independent induction of protecive immunity by two structural glycoproteins显示文摘 | KONIG M LENGSFELD T PAULY T | 1995 | J Virol1995，69，10： | 1 |
| 16 | Reassessing the environmental Kuznets Curve for CO2 Emissions: A robustness exercise 显示文摘 | Galeotti M Lanza A Pauli F | 2006 | Ecological Economics2006，57，： | 1 |
| 17 | Classical swine fever virus:Independent induction of protective immunity by two structural glycoproteins显示文摘 | Konig M Lengsfeld T Pauly T | 1995 | J Virol1995，69，10： | 1 |
| 18 | Decontamination of surgical instruments from prion proteins显示文摘 | Lemmer K Mieke M Pauli G | 2004 | Journal of General Virology2004，85，： | 1 |
| 19 | Spectrum of KIT/ PDGFRA/BRAF mutations and l?hosphatidylinositol-3-Kinase pathway geue alterations in gastrointestinal stromal tumors (GIST) 显示文摘 | Daniels M Lurkin I Pauli R | 2011 | Cancer Lett2011，312，： | 1 |
| 20 | Multi-scale feature extraction on point-sampled surfaces显示文摘 | PAULY M KEISER R GROSS M | 2003 | Computer Graphics Forum2003，22，3： | 1 |
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