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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Synthesis and scale-up of HNIW from 2, 6, 8, 12-tetraacetyl-4, 10-dibenzyl-2, 4, 6, 8, 10, 12-hexaazaisowurtzitane显示文摘 | Nikolaj V L Ulf W Patrick G | 2000 | Org Proc Res & Development2000，4，3： | 1 |
| 3 | Coronary stents: Current status显示文摘 | SCOT G PATRICK W SERRUYS M D | 2010 | Journal of American College of Cardiology2010，56，10： | 1 |
| 4 | Near infrared spectroscopy in patient with sever brain injury and elevated ICP:a pilot study显示文摘 | Melville S Mark G | 1997 | Acta Neurochir Suppl(wien)1997，70，1： | 1 |
| 5 | Synthesis and scale-up of HNIW from 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane显示文摘 | V L Nikolaj W Ulf G Patrick | 2000 | Org Proc Res & Develop2000，4，3： | 1 |
| 6 | Interleukin-8 signaling attenuates TRAIL-and chemotherapyinduced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells显示文摘 | Catherine W Timothy W Patrick G J | 2008 | Mol Cancer Ther2008，7，9： | 1 |
| 7 | Effect of estuarine sediment pH and oxidation-reduction potential on microbial hydrocarbon degradation 显示文摘 | Hambrick G A DeLaune R D Patrick W H | 1980 | Appl Environ Mierobiol1980，40，2： | 1 |
| 8 | Costs and returns ofeducation in five agricultural regions of eastern Brazil显示文摘 | KEHRBERG E W | 1973 | American Journal of Agricultural Economics1973，，55： | 1 |
| 9 | Pathogenesis of endometriosis显示文摘 | Annemiek W N Patrick G G Ayse Y D | 2004 | Best Pract Res Clob2004，18，2： | 1 |
| 10 | Metabolic engineering of sugars and simple sugar derivatives in plants显示文摘 | Patrick J W Botha F C Birch R G | 2013 | Plant Biotechnology Journal2013，11，2： | 1 |
| 11 | The kinetics of the hydriding of uranium metal显示文摘 | POWELL G L HARPER W L KIRK- PATRICK J R | 1991 | J Less-Common Met1991，，： | 1 |
| 12 | Coronary stents: Current status 显示文摘 | SCOT G PATRICK W SERRUYS M D | 2010 | Journal of the American College of Cardiology2010，56，10： | 1 |
| 13 | Disease outbreak detection system using syndromic data in the greater Washington DC area 1 1 Information for the full text of this article is available via AJPM Online at www.ajpm-online.net.显示文摘 | Michael D Lewis Julie A Pavlin Jay L Mansfield Sheilah O’Brien Louis G Boomsma Yevgeniy Elbert Patrick W Kelley | 2002 | American Journal of Preventive Medicine2002，，3： | 1 |
| 14 | Sources of and Responses to Risk:Factor Analyses of Large-scale US Combelt Farmers显示文摘 | Musser W N | 1997 | Manaholt Studies1997，，7： | 1 |
| 15 | Sources of and Responses to Risk: Factor Analyses of Large-scale US Cornbeh Farmers 显示文摘 | Patrick G F Musser W N | 1997 | Manshoh Studies1997，7，： | 1 |
| 16 | Amplitude mask patterned on an excimer laser mirror for high intensity writing of long period fibre gratings显示文摘 | Patrick H J Askins C G McElhanon R W | 1997 | Electronics Letters1997，33，13： | 1 |
| 17 | Delay differential equations via the matrix Lambert W function and bifurcation anal- ysis: application to machine tool chatter显示文摘 | SUN Yi Patrick W Nelson ULSOY A G | 2007 | Mathematical Biosciences and Engineering2007，4，2： | 1 |
| 18 | Plasma-enhanced Chemical Vapor Deposition of Silicon Dioxide Using Tetraethoxysilane and Oxygen: Characterization and Properties of Films显示文摘 | PATRICK W J SCHWARTZ G C CHAPPLE-Soko J D I | 1992 | J Electrochem Soc1992，139，9： | 1 |
| 19 | Enhanced coagulation:its effect on NOM removal and chemical costs显示文摘 | Gil G Patrick W Matthew M | 1995 | J AWWA1995，87，1： | 1 |
| 20 | Effects of mycophenolic acid on IL-6 expression of human renal proximal and distal tubular cells in vitro 显示文摘 | Patrick CB Binytha W Helmut G | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
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