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| 1 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 2 | Chitosan -poly(acrylic) acid polyionic complex: in vivo study to demonstrate prolonged gastric retention 显示文摘 | Torrado S Prada P Paloma M | 2004 | Biomaterials2004，25，： | 1 |
| 3 | Release of Amoxicillin from Polyionic Complexes of Chitosan and Poly(acrylic acid):Study of Polymer/Polymer and Polymer/Drug Interactions within the Network Structure显示文摘 | Paloma M Torre D L Enobakhare Y | 2004 | Biomaterials2004，24，8： | 1 |
| 4 | Measurement of prethrom- botic markers in the assessment of acquired hypercoagulable states显示文摘 | Lopez Y Paloma M J Rifon J | 1999 | Thromb Res1999，93，2： | 1 |
| 5 | Novel mutations in the TULP1 gene catusing autosomal recessive retis pigmentosa显示文摘 | Paloma E Hjelmqvist L Bayes M | 2000 | Invest Ophthalmol Vis Sci2000，41，3： | 1 |
| 6 | End - user oriented strategies to facilitate multi - organizational adoption of e- mergency management information systems 显示文摘 | Aedo I Paloma D P John M C | 2010 | Informa- tion Processing dr Management2010，46，1： | 1 |
| 7 | Phylogenetic relationships of European strains of porcine reproductive and respiratory syndrome virus(PRRSV)inferred from DNA sequences of Putative ORF5 and ORF7 genes显示文摘 | Paloma S Rafael Z M Jesus Marti | 1996 | Virus Research1996，42，6： | 1 |
| 8 | A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-indueed reproductive failure显示文摘 | ADRIAAN F G CHRISTIANNE J M PALOMA R | 2006 | Vaccine2006，24，24： | 1 |
| 9 | A preli minary search for anthocya- nin-β-D-glucosidase activity in non-Sacharomyces wine yeasts显示文摘 | Paloma M Virginia R | 2000 | Internation J Food Science and Technology2000，35，： | 1 |
| 10 | Comparison of three media formulations for in vitro cu1ture of coconut embryos显示文摘 | Ri11o E P Paloma M B F | 1990 | O1eagineux1990，45，7： | 1 |
| 11 | Shrimp farming in coastal Brazil: Reasons for market failure and sustainability challenges 显示文摘 | Monica C S A Paloma M Pedro E S L | 2011 | Ocean & Coastal Management2011，54，9： | 1 |
| 12 | Characterization of peni- cillium species by ribosomal DNA sequencing and BOX, ERIC and REP-PCR analysis 显示文摘 | CRISTINA R JAIME C PALOMA M | 2009 | Mycopathologia2009，168，： | 1 |
| 13 | Measurement of prethrombotic markers in the assessment of acquired hypercoagulable statetes 显示文摘 | Lopez Y Paloma M J | 1999 | Throinbo Res1999，93，2： | 1 |
| 14 | Phylogenetic relationships of strains of porcine reproductive and respiratory syndrome virus(PRRSV) inferred from DNA sequences of Putative ORF-5 and ORF-7genes显示文摘 | Paloma S Rafael Z M jesus Marti e al | 1996 | Virus Research1996，42，： | 1 |
| 15 | End-User Oriented Strategies To Facilitate Multi-Organizational Adoption Of Emergency Management Information Sys- tems 显示文摘 | Aedo Ignacio Diaz Paloma Carroll John M | 2011 | Information Processing & Management2011，46，1： | 1 |
| 16 | Maximum information stratification method for controlling item exposure in com- puterized adaptive testing 显示文摘 | Ramon B J Paloma M Julio O | 2006 | Psicothema2006，18，1： | 1 |
| 17 | Intellectual capital in universities: improving transparency an internal management 显示文摘 | PALOMA S M SUSANA E | 2006 | Journal of Intellectual Capital2006，7，4： | 1 |
| 18 | Measurement of prethrombotic markers in the assessment of acquired hypercoagulable states显示文摘 | LOPEZY PALOMA M J RIFONJ | 1999 | Throm Res1999，93，2： | 1 |
| 19 | Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells 显示文摘 | PALOMA B B ENRIQUE P E FRESNO V A M | 2008 | Toxicol Vitro2008，22，6： | 1 |
| 20 | Determination of toxic cyclic heptapeptides by liquid chromatography with detection using ultra-violet, protein phosphatase assay and tandem mass spectrometry 显示文摘 | Ortea Paloma Muniz Allis Orla Healy Brendan M | 2004 | Chemosphere2004，55，10： | 1 |
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