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| 1 | 息肉状脉络膜血管病和脉络膜新生血管患者房水中血管内皮生长因子和色素上皮衍生因子的表达水平显示文摘PURPOSE: To determine the aqueous levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in patients with active polypoidal choroidal vasculopathy (PCV) and choroidal neovascularization (CNV)-secondary to age-related macular degeneration (AMD) and pathologic myopia. DESIGN: Prospective,comparative control study. METHODS: Aqueous humors were collected from 32 eyes of 32 patients for either active PCV or CNV. Among them,11 eyes had active and symptomatic PCV,12 eyes had active CNV secondary to AMD,and nine eyes had active CNV of pathologic myopia. Levels of VEGF and PEDF were determined by commercially available enzyme-linked immunosorbent assay kits. A group of 10 aqueous samples from 10 patients who underwent cataract surgery without other ocular or systemic diseases comprised the controls. RESULTS: VEGF concentrations in aqueous humor were markedly increased in patients with PCV,CNV of AMD,and CNV of myopia when compared with the controls (analysis of variance ANOVA,P < .001). VEGF levels in eyes with PCV were,however,significantly lower than those of exudative AMD (P=.045)-. The PEDF levels were also significantly different among the groups (ANOVA,P=.001),and we observed increased levels in PCV,CNV of AMD,and CNV of myopia. CONCLUSIONS: VEGF and PEDF factors were coexpressed and increased with positive correlation in aqueous humor of eyes with active PCV. The different levels of both factors in eyes of PCV and AMD might suggest distinct clinical entities or different angiogenesis courses between PCV and AMD. | Tong J. -P. Chan W. -M. Liu D. T. L. 杨秀梅(译) | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，6： | 7 |
| 2 | Comprehensive characterization of indoor airborne bacterial profile显示文摘This is the first detailed characterization of the airborne bacterial profiles in indoor environments. Two restaurants were selected for this study. Fifteen genera of bacteria were isolated from each restaurant and identified by three different bacterial identification systems including MIDI, Biolog and Riboprinter . The dominant bacteria of both restaurants were Gram-positive bacteria in which Micrococcus and Bacillus species were the most abundant. Most bacteria identified were representative species of skin and respiratory tract of human, and soil. Although the bacterial levels in these two restaurants were below the limit of the Hong Kong Indoor Air Quality Objective (HKIAQO) Level 1 standard (i.e., < 500 cfu/m3), the majority of these bacteria were opportunistic pathogens. These results suggested that the identity of airborne bacteria should also be included in the IAQ to ensure there is a safety guideline for the public. | P. L. Chan P. H. F. Yu Y. W. Cheng C. Y. Chan P. K. Wong | 2009 | Journal of Environmental Sciences2009，21，8： | 5 |
| 3 | Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial显示文摘 | S. L. Samson P. Sathyanarayana M. Jogi E. V. Gonzalez A. Gutierrez R. Krishnamurthy R. Muthupillai L. Chan M. Bajaj | 2011 | Diabetologia2011，，12： | 3 |
| 4 | One-year record of organic and elemental carbon in fine particles in downtown Beijing and Shanghai显示文摘 | Yang F. He K. Ye B. Chen X. Cha L. Cadle S. H. Chan T. Mulawa P. A | 2005 | Atmospheric Chemistry and Physics2005，，51： | 3 |
| 5 | A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma显示文摘 | Stephen L. Chan Frankie K. F. Mo Cesar S. C. Wong Charles M. L. Chan Linda K. S. Leung Edwin P. Hui Brigette B. Ma Anthony T. C. Chan Tony S. K. Mok Winnie Yeo | 2011 | Cancer2011，，16： | 2 |
| 6 | Visual outcomes and optical performance of a monofocal intraocular lens and a new-generation multifocal intraocular lens显示文摘 | Jorge L. Alió David P. Pi?ero Ana B. Plaza-Puche Maria Joanna Rodriguez Chan | 2011 | Journal of Cataract & Refractive Surgery2011，，2： | 1 |
| 7 | Study of 1-3 PZT Fibre/Epoxy Composites with Low Volume Fraction of Ceramics显示文摘 | S. H. Choy H. L. W. Chan M. W. Ng P. C. K. Liu | 2004 | Integrated Ferroelectrics2004，，1： | 1 |
| 8 | Evidence for Altered Numb Isoform Levels in Alzheimers Disease Patients and a Triple Transgenic Mouse Model显示文摘 | Srinivasulu Chigurupati Meenu Madan Eitan Okun Zelan Wei Jogi V. Pattisapu Mohamed R. Mughal Mark P. Mattson Sic L. Chan | 2011 | Journal of Alzheimers Disease2011，，： | 1 |
| 9 | Prognostic significance of the total dose of cisplatin administered during concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma显示文摘 | Herbert H. Loong Brigette B.Y. Ma Sing-Fai Leung Frankie Mo Edwin P. Hui Michael K. Kam Stephen L. Chan Brian K.H. Yu Anthony T.C. Chan | 2012 | Radiotherapy and Oncology2012，，3： | 1 |
| 10 | Release characteristics of pectin microspheres prepared by an emulsification technique显示文摘 | T. W. Wong L. W. Chan H. Y. Lee P. W. S. Heng | 2002 | Journal of Microencapsulation2002，，4： | 1 |
| 11 | Technical refinements in laparoscopic repair of childhood inguinal hernias显示文摘 | K. L. Chan P. K. H. Tam | 2004 | Surgical Endoscopy2004，，6： | 1 |
| 12 | Prevalence and extent of subclinical atherosclerosis in patients with psoriasis显示文摘 | K.‐H. Yiu C.‐K. Yeung C.‐T. Zhao J. C. Chan C.‐W. Siu S. Tam C.‐S. Wong G. H. Yan W. S. Yue P.‐L. Khong H. H. Chan H.‐F. Tse | 2012 | J Intern Med2012，，： | 1 |
| 13 | Shorter durations and lower doses of peginterferon alfa‐2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C显示文摘 | Y.‐F. Liaw J.‐D. Jia H.L.Y. Chan K.H. Han T. Tanwandee W.L. Chuang D.M. Tan X.Y. Chen E. Gane T. Piratvisuth L. Chen Q. Xie J.J.Y. Sung C. Wat C. Bernaards Y. Cui P. Marcellin | 2011 | Hepatology2011，，： | 1 |
| 14 | Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B—related pathway显示文摘 | G. G. Chen N.-C. Liang J. F. Y. Lee U. P. F. Chan S. H. Wang B. C. S. Leung K. L. Leung | 2004 | APOPTOSIS2004，，5： | 1 |
| 15 | Diffusion-weighted MR imaging of the liver: distinguishing hepatic abscess from cystic or necrotic tumor显示文摘 | J. H. M. Chan E. Y. K. Tsui S. H. Luk A. S. L. Fung M. K. Yuen M. L. Szeto Y. K. Cheung K. P. C. Wong | 2001 | Abdominal Imaging2001，，2： | 1 |
| 16 | Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress显示文摘 | Dong Liu Sic L. Chan Nadja C. Souza-Pinto John R. Slevin Robert P. Wersto Ming Zhan Khadija Mustafa Rafael Cabo Mark P. Mattson | 2006 | NeuroMolecular Medicine2006，，： | 1 |
| 17 | Body-mind-spirit intervention for IVF Women显示文摘 | Celia H. Y. Chan Cecilia L. W. Chan S. M. Ng Ernest H. Y. Ng P. C. Ho | 2005 | Journal of Assisted Reproduction and Genetics (-)2005，，11： | 1 |
| 18 | Implementation of an All-Optical NOR Gate Using a Multi-Wavelength Injection-Locked Diode Laser显示文摘We demonstrated an all optical NOR gate operating at 10 Gb/s using a multi-wavelength mutual injection-locked Fabry-Perot laser diode (FP-LD). | K. K. Qureshi L. Y. Chan P. K. A. Wai L. F. K. Lui W. H. Chung Hwa-yaw Tam | 2003 | 光学学报2003，23，S1： | 1 |
| 19 | Perovskite barium zirconate titanate nanoparticles directly synthesized from solutions显示文摘 | J. Q. Qi Y. Wang W. P. Chen L. T. Li H. L. W. Chan | 2006 | Journal of Nanoparticle Research2006，，6： | 1 |
| 20 | A Simple Tool to Identify Asian Women at Increased Risk of Osteoporosis显示文摘 | L. K. H. Koh W. Ben Sedrine T. P. Torralba A. Kung S. Fujiwara S. P. Chan Q. R. Huang R. Rajatanavin K. S. Tsai H. M. Park J. Y. Reginster | 2001 | Osteoporosis International2001，，： | 1 |
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