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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Towards property oriented testing 显示文摘 | MACHADO P D L SILVA D A MOTA A C | 2007 | Electrical Notes in Theoretical Computer Science2007，184，： | 1 |
| 3 | Mechanical characterization of reactively magnetron-sputtered TiN films 显示文摘 | Vaz F Machado P Rebouta L | 2003 | Surface and Coatings Technology2003，，： | 1 |
| 4 | Source,level and age differences in fat utilization in broilers 显示文摘 | Machado L P Vieira S L Quadros R V | 2003 | Poul Sci2003，82，： | 1 |
| 5 | Inhibition of interleukin - lbeta re- duces mouse lung inflammation induced by ex- posure to cigarette smoke 显示文摘 | Castro P Legora - Machado A Cardilo - Reis L | 2004 | Eur J Phar- macol2004，498，123： | 1 |
| 6 | No tillageand crop rotation effects on soil aggregation and organic carbonin a Rhodic Ferralsol from southern Brazil显示文摘 | MADARI B MACHADO P L O A TORRES E | 2005 | Soil and TillageResearch2005，80，18： | 1 |
| 7 | Time-series forecasting through wavelets transformation and a mixture of expert models显示文摘 | Milidiu R L Machado R J Rentera R P | 1999 | Neurocompuring1999，，28： | 1 |
| 8 | Soil organic carbon and fractions of a Rhodic Ferralsol under the influence of tillage and crop rotation systems in southern Brazil显示文摘 | Freixo A A Machado P L Santos H P | 2002 | Soil and Tillage Research2002，64，34： | 1 |
| 9 | Life cycle as- sessment Of wastewater treatment options for small and decentralized communities 显示文摘 | Machado A P Urbano L Brito A G | 2007 | Water Sci Technol2007，56，3： | 1 |
| 10 | Nonlinear dynamics and chaos in coupled shape memory oscillators 显示文摘 | Machado L G Savi M A Pacheco P M | 2003 | International Journal of Solids and Structures2003，40，： | 1 |
| 11 | Angiotensin (1 -7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restore sbaroreflex bradycardia显示文摘 | Cangussu L M de Castro U G do Pilar Machado R Silva M E Ferreira P M dos Santos R A | 2009 | Peptides2009，30，： | 1 |
| 12 | Soil organic carbon and fractions of a Rhodic Ferralsol under the influence of tillage and crop rotation systems in southern Brazil显示文摘 | Freixo A A Machado P L O Santos H P | 2002 | Soil and Tillage Research2002，64，34： | 1 |
| 13 | Soil organic carbon and fractions of a Rhodie Ferralsol under the influence of tillage and crop rotation systems in southern Brazn 显示文摘 | Freixo A A P L Machado H P Santos | 2002 | Soil Till Res2002，64，： | 1 |
| 14 | Time-series forecasting through wavelets transformation and a mixture of expert models 显示文摘 | MILIDIU R L MACHADO R J RENTERA R P | 1999 | Neurocomputing1999，28，： | 1 |
| 15 | Mechanical characterization of reactively magnetron-sputtered TiN films 显示文摘 | Vaz F Machado P Rebouta L | 2003 | Surface and Coatings Technology2003，，： | 1 |
| 16 | No tillage and crop rotation effects on soil aggregation and organic carbon in ahodic Ferralsol from southern Brazil显示文摘 | Madari B Machado P L O A Torres E | 2005 | Soil and Tillage Research2005，80，： | 1 |
| 17 | Universal scaling of respiratory metabolism,size and nitrogen in plants显示文摘 | Reich P B Tjoelker M G Machado J L | 2006 | Nature2006，439，： | 1 |
| 18 | Universalscaling of respiratory metabolism,size and nitrogen in plants显示文摘 | Reich P B Tjoelker M G Machado J L | 2006 | Nature2006，439，： | 1 |
| 19 | Optimized heat transfer correlations for pure and blended refrigerants显示文摘 | PORTO M P PEDRO H T C MACHADO L | 2015 | International Journal of Heat and Mass Transfer2015，85，： | 1 |
| 20 | Nonlinear Dynamics and Chaos in Coupled Shape Memory Oscillators 显示文摘 | Machado L G Savi M A Pacheco P M | 2003 | International Journal of Solids and Structures2003，40，19： | 1 |
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