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| 1 | Effects of estrogen replacement therapy on apoptosis and vascular endothelial growth factor expression in ocular surface epithelial cells:An experimental study显示文摘AIM:To investigate the effects of estrogen replacement therapy (ERT) on apoptosis and vascular endothelial growth factor (VEGF) expression in ocular surface in an experimental rat model.· METHODS:Forty female,Wistar rats were randomized in 4 groups in the study.Subcutaneous ERT (17β-estradiol,10g/kg/day) was administered to the first group without ovariectomy and to the second group with ovariectomy for three months.Third group had only ovariectomy and fourth group had sham operation.All rats were sacrificed in estrous cycles determined by vaginal smear test and their right eyes were enucleated at the end of the third month.Enucleated eyes were analyzed by immunohistochemical method for expressions of caspase-3,bcl-2,VEGF and TUNEL assay.· RESULTS:Caspase-3 expression of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.005),and group 2 (P =0.007).TUNEL score of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.006).TUNEL score of corneal epithelium was significantly higher in group 3 than group 2 (P =0.012),and group 4 (P =0.002).There was no significant difference between groups in that bcl-2 and VEGF expressions.· CONCLUSION:We determined increased apoptosis in ocular surface epithelial cells in ovariectomized rats.ERT and endogen estrogen decreased the apoptosis,and did not result in difference in VEGF expression between the groups.Estrogen may be beneficial for the treatment of apoptosis-mediated ocular surface disorders such as dry eye.Further studies are needed on this subject for a better understanding of the role of estrogen and to provide a new insight for treatment and prevention of apoptosis-mediated ocular surface disorders. | Fatih zcura Sema Oru Dndar Emel Dikicioglu etin Nahit Beder Mehmet Dndar | 2012 | International Journal of Ophthalmology(English edition)2012，5，1： | 7 |
| 2 | Effect of exercise on colorectal cancer prevention and treatment显示文摘In recent years, because of improved cancer screening, detection and treatment modalities, a rapid increase in the population of colorectal and other cancer survivors has been observed. The increasing population has justified the requirement of preventive strategies such as lifestyle modifications with regard to obesity, physical activity, diet and smoking. Physical activity may prevent approximately 15% of the colon cancers. Furthermore, several observational studies have demonstrated the efficacy and dose-dependent and anti-cancer effects of exercise on decreasing the mortality and risk of recurrence before and after the colorectal cancer(CRC) diagnosis. However, the required exercise dose,type and intensity are yet unclear. The results of randomised prospective studies are expected to determine the optimal amount, type and intensity of exercise and formulate the most appropriate exercise plan and guidelines, according to the requirements and comorbidities of the patients. In addition, recent studies have focused on the molecular and genetic mechanisms underlying the effect of physical activity on disease outcomes and recurrence rates. This review aimed to investigate the effects of physical activity and the biological basis of these effects in preventing the risk and recurrence of CRC and decreasing the hazards of cancer and cancer treatment. | Zeynep Oru? Muhammed Ali Kaplan | 2019 | World Journal of Gastrointestinal Oncology2019，11，5： | 2 |
| 3 | Low- flow- simulation of the Dongjiang basin based on Xinanjiang watershed hydrologicalmodel 显示文摘 | H U A N G G u oru C H E N Yong-qin | 2006 | Journal Article2006，34，： | 1 |
| 4 | Sexual life following total abdominal hysterectomy显示文摘 | Kuscu NK Orue S Ceylan E | 2005 | Arch Gynecol Obstet2005，271，31： | 1 |
| 5 | Cyberbullying in adoles-cents:Modalities and aggressors' profile显示文摘 | CALVETE E ORUE I ESTVEZ A | 2010 | Comput Hum Behav2010，26，5： | 1 |
| 6 | Inhibition of reninangiotensin system in experimental acute pancreatitis in rats: a new therapeutic target? 显示文摘 | Orue N Ozutemiz O Nart D | 2010 | Exp Toxicol Pathol2010，62，4： | 1 |
| 7 | Meniscal tears:pathologfc correation with MR imaging显示文摘 | Stoller PW Martfn C Orues JV 3rd | 1987 | Eadiology1987，165，5： | 1 |
| 8 | Endoerowns: review 显示文摘 | Sevimli G Cengiz S Oru S | 2015 | J Istan- bul Univ Fac Dent2015，49，2： | 1 |
| 9 | Synergy analysis of collaborative supply chain management in energy systems using multi-period MILP 显示文摘 | Soylu A Orue C Turkay M | 2006 | European Journal of Operational Research2006，174，1： | 1 |
| 10 | Office hystero- scopic findings in patients with two,three,and four or more, consecutive miscarriages 显示文摘 | Seckin B Sarikaya E Orue AS | 2012 | Eur J Contracept Reprod Health Care2012，17，5： | 1 |
| 11 | Effect of extrusion cooking on structure and functional properties of pea and kidney bean proteins 显示文摘 | Alonso R Orue E Zabalza M J | 2000 | Journal of the Science of Food and Agriculture2000，80，3： | 1 |
| 12 | Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy显示文摘 | Jarreta D Orus J Barrientos A | 2000 | Cardiovasc Res2000，45，4： | 1 |
| 13 | Very large magnetoimpedance (MI) in FeNi/Au multilaryer filem systems显示文摘 | de Cos D Fry N Orue I | 2006 | Sensors and Actuators A2006，129，12： | 1 |
| 14 | Prognostic valuve of serum cytokines in patients with congestive heart failure显示文摘 | Orus J Roig E Perez V F | 2000 | J Heart Lung Transplant2000，19，： | 1 |
| 15 | Local structure and ferromagnetic character of Fe-B and Fe-P amorphous alloys显示文摘 | ORUE I PIZZINI S | 2000 | Phys Rev:B2000，62，9： | 1 |
| 16 | Prognostic value of serum cytokines in patients with congestive heart failure 显示文摘 | Orus J Roig E Perez-Villa F | 2000 | J Heart Lung Transplant2000，19，5： | 1 |
| 17 | Glucagonoma and pseudoglucagonoma syndrome 显示文摘 | Echenique-Elizondo M Tuneu Vails A Elorza Orue JL | 2004 | JOP2004，5，4： | 1 |
| 18 | Local structure and ferromagnetic character of Fe - B and Fe - P amorphous alloys 显示文摘 | I Orue Pgorria S Pizzini | 2000 | Phys Rev B2000，62，9： | 1 |
| 19 | La Peste des Petits Ruminants en Afrique Occidentale Francaise, ses Rap- ports avecia Peste Bovine 显示文摘 | Mornet P Orue J Gilbert Y | 1956 | R6v E14v Med Vet Pays Trop1956，9，12： | 1 |
| 20 | The effect of waiting time on local control and survival in head and neck carcinoma patients treated with radiotherapy显示文摘 | de Vega M Orus C | 2003 | Radiother Oncol2003，66，： | 1 |
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