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| 1 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 2 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 3 | Intimal pericytes as the second line of immune defence in atherosclerosis显示文摘Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions. | Ekaterina A Ivanova Yuri V Bobryshev Alexander N Orekhov | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 4 | Stabilization and Destabilization of Austenite in Cr-Ni Co-Mo Maraging Steel显示文摘 | Nikol'skaya V L Orekhov N G Pevzner L M | 1979 | Metal Science and Heat Treatment1979，21，9： | 1 |
| 5 | Macrophages in immunopa- thology of atherosclerosis : a target for diagnostics and therapy 显示文摘 | Orekhov AN Sobenin IA Gavrilin MA | 2015 | Curr Pharm Des2015，21，： | 1 |
| 6 | Effect of Retained Austenite on the Properties of Cast Stainless Steels 显示文摘 | Nikol'skaya L Pevzner L M Orekhov N G | 1975 | Metal Science and Heat Treatment1975，17，9： | 1 |
| 7 | Mathematical model of monitoring the embankment dam of the Khoabin hydraulic power system 显示文摘 | Vladimirov V B Zaretskij Yu K Orekhov V V | 2003 | Gidrotekhnicheskoe Stroitel'' stvo2003，，6： | 1 |
| 8 | Simulator training for the high technology ship crews显示文摘 | AIZINOV S D OREKHOV A V | 2010 | Gyroscopy and Navigation2010，，1： | 1 |
| 9 | Plasmacytoiddendritic cells: development, functions, and role in atheroscle- rotie inflammation显示文摘 | Chistiakov DA Orekhov AN Sobenin IA | 2014 | Front Physiol2014，5，： | 1 |
| 10 | Vascular smooth muscle cell in a/herosclerosis显示文摘 | Chistiakov DA Orekhov AN Bobryshev YV | 2015 | Acta Physiol (Oxf)2015，214，1： | 1 |
| 11 | Contribution of neovas- eularization and intraplaque haemorrhage to atherosclerotic plaque progression and instability显示文摘 | Chistiakov DA Orekhov AN Bobryshev YV | 2015 | Acta Physiol( Oxf)2015，213，3： | 1 |
| 12 | Contribution ofneovascularization and intraplaque haemorrhage to atheroscleroticplaque progression and instability显示文摘 | Chistiakov DA Orekhov AN Bobryshev YV | 2015 | Acta Physiologica2015，213，3： | 1 |
| 13 | Simulator training for the high technology ship crews显示文摘 | Aizinov S Orekhov A | 2010 | Gyroscopy and Navigation2010，1，4： | 1 |
| 14 | Regulatory T cells in atherosclerosis and strategies to induce the endogenous atheropro- teetive immune response 显示文摘 | Chistiakov DA Subenin IA Orekhov AN | 2013 | hnmunl Lett2013，151，1： | 1 |
| 15 | Strategies to deliver microRNAs as potential therapeutics in the treatment of cardiovascular pathology 显示文摘 | Chistiakov DA Sobenin IA Orekhov AN | 2012 | Drug Deliv2012，19，8： | 1 |
| 16 | LDL electronegativity in- dex: a potential novel index for predicting cardiovascular disease 显示文摘 | Ivanova E A Bobryshev Y V Orekhov A N | 2015 | Vasc Health Risk Manag2015，11，： | 1 |
| 17 | Effect of retained austenite on the properties of cast stainless steels显示文摘 | Nikol'skaya V L Pevzner L M Orekhov N G | | 0，，09： | 1 |
| 18 | Vas- cular smooth muscle cell in atherosclerosis 显示文摘 | CHISTIAKOV D A OREKHOV A N BOBRYSHEV Y V | 2015 | Acta Physiol (Oxt)2015，214，1： | 1 |
| 19 | A comparison of convex and non-convex compressed sensing applied to multidimensional NMR显示文摘 | Kazimierczuk K Orekhov V Y | 2012 | J Magn Reson2012，223，： | 1 |
| 20 | Strategies to deliver microRNAs as potential therapeutics in the treatment of cardiovascular pathology显示文摘 | Dimitry A. Chistiakov Igor A. Sobenin Alexander N. Orekhov | 2012 | Drug Delivery2012，，： | 1 |
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