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| 1 | Analysis of ABC (D) stratification for screening patients with gastric cancer显示文摘AIM:To evaluate the value of ABC(D) stratification [combination of serum pepsinogen and Helicobacter pylori(H.pylori) antibody]of patients with gastric cancer.METHODS:Ninety-five consecutive patients with gastric cancer were enrolled into the study.The serum pepsinogenⅠ(PGⅠ) /pepsinogenⅡ(PGⅡ) and H.pylori antibody levels were measured.Patients were classified into five groups of ABC(D) stratification according to their serological status.Endoscopic findings of atrophic gastritis and histological differentiation were also analyzed in relation to the ABC(D) stratification.RESULTS:The mean patient age was(67.9±8.9) years.Three patients(3.2%) were classified into group A,7 patients(7.4%) into group A',27 patients(28.4%) into group B,54 patients(56.8%) into group C,and 4patients(4.2%) into group D,respectively.There were only three cases in group A when the patients taking acid proton pump inhibitors and those who had undergone eradication therapy for H.pylori(group A') were excluded.These three cases had mucosal atrophy in the grey zone according to the diagnostic manual of ABC(D) stratification.Histologically,the mean age of the patients with well differentiated adenocarcinoma was significantly higher than that of the patients with poorly differentiated adenocarcinoma(P<0.05) .There were no differences in the pattern of atrophy in the endoscopies between the well differentiated and poorly differentiated groups.CONCLUSION:ABC(D) stratification is a good method for screening patients with gastric cancers.Endoscopy is needed for grey zone cases to check the extent of mucosal atrophy. | Tomohiro Kudo Satoru Kakizaki Naondo Sohara Yasuhiro Onozato Shinichi Okamura Yoshikatsu Inui Masatomo Mori | 2011 | World Journal of Gastroenterology2011，17，43： | 17 |
| 2 | Can endoscopic submucosal dissection be safely performed in a smaller specialized clinic?显示文摘AIM:To investigate whether endoscopic submucosal dissection(ESD) can be safely performed at small clinics,such as the Shirakawa Clinic.METHODS:One thousand forty-seven ESDs to treat gastrointestinal tumors were performed at the Shirakawa Clinic from April 2006 to March 2011.The efficacy,technical feasibility and associated complications of the procedures were assessed.The ESD procedures were performed by five endoscopists.Sedation was induced with propofol for esophagogastorduodenal ESD.RESULTS:One thousand forty-seven ESDs were performed to treat 64 patients with esophageal cancer(E),850 patients with gastric tumors(G:764 patients with cancer,82 patients with adenomas and four others),four patients with duodenal cancer(D) and 129 patients with colorectal tumors(C:94 patients with cancer,21 patients with adenomas and 14 others).The en bloc resection rate was 94.3%(E:96.9%,G:95.8%,D:100%,C:79.8%).The median operation time was 46 min(range:4-360 min) and the mean size of the resected specimens was 18 mm(range:2-150 mm).No mortal complications were observed in association with the ESD procedures.Perforation occurred in 12 cases(1.1%,E:1 case,G:9 cases,D:1 case,C:1 case) and postoperative bleeding occurred in 53 cases(5.1%,G:51 cases,D:1 case,C:1 case);however,no case required either emergency surgery or blood transfusion.All of the perforations and postperative bleedings were resolved by endoscopic clipping or hemostasis.The other problematic complication observed was pneumonia,which was treated with conservative therapy.CONCLUSION:ESD can be safely performed in a clinic with established therapeutic methods and medical services to address potential complications. | Naondo Sohara Satoshi Hagiwara Riki Arai Haruhisa Iizuka Yasuhiro Onozato Satoru Kakizaki | 2013 | World Journal of Gastroenterology2013，19，4： | 15 |
| 3 | Analysis of colonoscopic perforations at a local clinic and a tertiary hospital显示文摘AIM:To define the clinical characteristics,and to assess the management of colonoscopic complications at a local clinic.METHODS:A retrospective review of the medical records was performed for the patients with iatrogenic colon perforations after endoscopy at a local clinic between April 2006 and December 2010.Data obtained from a tertiary hospital in the same region were also analyzed.The underlying conditions,clinical presentations,perforation locations,treatment types(operative or conservative) and outcome data for patients at the local clinic and the tertiary hospital were compared.RESULTS:A total of 10 826 colonoscopies,and 2625 therapeutic procedures were performed at a local clinic and 32 148 colonoscopies,and 7787 therapeutic procedures were performed at the tertiary hospital.The clinic had no perforations during diagnostic colonoscopy and 8(0.3%) perforations were determined to be related to therapeutic procedures.The perforation rates in each therapeutic procedure were 0.06%(1/1609) in polypectomy,0.2%(2/885) in endoscopic mucosal resection(EMR),and 3.8%(5/131) in endoscopic submucosal dissection(ESD).Perforation rates for ESD were significantly higher than those for polypectomy or EMR(P < 0.01).All of these patients were treated conservatively.On the other hand,three(0.01%) perforation cases were observed among the 24 361 diagnostic procedures performed,and these cases were treated with surgery in a tertiary hospital.Six perforations occurred with therapeutic endoscopy(perforation rate,0.08%;1 per 1298 procedures).Perforation rates for specific procedure types were 0.02%(1 per 5500) for polypectomy,0.17%(1 per 561) for EMR,2.3%(1 per 43) for ESD in the tertiary hospital.There were no differences in the perforation rates for each therapeutic procedure between the clinic and the tertiary hospital.The incidence of iatrogenic perforation requiring surgical treatment was quite low in both the clinic and the tertiary hospital.No procedure-related mortalities occurred.Performing closure with endoscopic clipping reduced the C-reactive protein(CRP) titers.The mean maximum CRP titer was 2.9 ± 1.6 mg/dL with clipping and 9.7 ± 6.2 mg/dL without clipping,respectively(P < 0.05).An operation is indicated in the presence of a large perforation,and in the setting of generalized peritonitis or ongoing sepsis.Although we did not experience such case in the clinic,patients with large perforations should be immediately transferred to a tertiary hospital.Good relationships between local clinics and nearby tertiary hospitals should therefore be maintained.CONCLUSION:It was therefore found to be possible to perform endoscopic treatment at a local clinic when sufficient back up was available at a nearby tertiary hospital. | Toshihiko Sagawa Satoru Kakizaki Haruhisa Iizuka Yasuhiro Onozato Naondo Sohara Shinichi Okamura Masatomo Mori | 2012 | World Journal of Gastroenterology2012，18，35： | 5 |
| 4 | Endoscopic submucosal dissection for early gastric cancers and large flat adenomas显示文摘 | Y. Onozato H. Ishihara H. Iizuka N. Sohara S. Kakizaki S. Okamura M. Mori | 2006 | Endoscopy2006，，10： | 3 |
| 5 | Endoscopic submucosal dissection for early gastric cancers and large flat adenomas显示文摘 | Y. Onozato H. Ishihara H. Iizuka N. Sohara S. Kakizaki S. Okamura M. Mori | 2006 | Endoscopy2006，，10： | 2 |
| 6 | Double-edged action of SOD mimetic in diabetic nephropathy显示文摘 | Asaba Kl Tojo A Onozato ML | 2007 | J Cardiovasc Pharmacol2007，49，1： | 1 |
| 7 | Experimental infection of cattle and goats with a foot-and-mouth disease virus isolate from the 2010 epidemic in Japan显示文摘 | Onozato H Fukai K Kitano R | 2014 | Archives of virology2014，159，11： | 1 |
| 8 | Protective effect of dietary potassium against vascular injury in salt-sensitive hypertension显示文摘 | Kido M Ando K Onozato ML | 2008 | Hypertension2008，51，2： | 1 |
| 9 | Genetic inactivation of crucian carp eggs using a simple X-ray irradiation apparatus显示文摘 | Fujikawa N Nakayama I Onozato H | 1993 | Bull Natl Res Inst Aquaculture1993，22，： | 1 |
| 10 | Oxidative stress and nitric oxide synthase in rat diabetic nephropathy,effect of ACEI and ARB显示文摘 | ONOZATO ML TOJO A GOTO A | 2002 | Kidney Int2002，61，1： | 1 |
| 11 | Prevalence of Foxp3 regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premaliguant lesions显示文摘 | Hiraoka N Onozato K Kosuge T | 2006 | Clin Cancer Res2006，12，18： | 1 |
| 12 | Endoscopic sub- mucosal dissection for early gastric cancers and large flat adeno- mas显示文摘 | ONOZATO Y ISHIHARA H IIZUKA H | 2006 | Endoscopy2006，38，10： | 1 |
| 13 | Angiotensin II blockade restores albumin reabsorption in the proximal tubules of diabetic rats 显示文摘 | Tojo A Onozato ML Kurihara H | 2003 | HypertensRes2003，26，5： | 1 |
| 14 | Optimization of dynamic allocation of transmitter power in a DS-CDMA cellular system using genetic algorithms 显示文摘 | SHIRAISHI Y ONOZATO Y | 2001 | IEICE Trans on Fundamentals2001，82，10： | 1 |
| 15 | Radical scavenging effect of gliclazide in diabetic rats fed with a high cholesterol diet显示文摘 | Onozato ML Tojo A Goto A | 2004 | Kidney Int2004，65，3： | 1 |
| 16 | Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB显示文摘 | Onozato ML Tojo A Goto A | 2002 | Kidney Int2002，61，： | 1 |
| 17 | Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney 显示文摘 | Chabrashvili T Tojo A Onozato ML | 2002 | Hypertension2002，39，2： | 1 |
| 18 | Oxidative stress and nitric ox- ide synthase in rat diabetic nephropathy, effect of ACEI and ARB 显示文摘 | Onozato ML Tojo A Goto A | 2002 | Kidney Int2002，61，1： | 1 |
| 19 | Suppressing renal NADPH oxidase to treat diabetic nephropathy 显示文摘 | TOJO A ASABA K ONOZATO M L | 2007 | Expert Opin Ther Targets2007，11，8： | 1 |
| 20 | Retrospective,matched case-control study comparing the oncologic outcomes between laparoscopic surgery and open surgery in patients with fight-sided colon cancer显示文摘 | Nakamura T Onozato W Mitomi H | 2009 | Surg Today2009，39，12： | 1 |
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