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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | The hyperbolic singular value decomposition and applications 显示文摘 | ONN R STEINHARDT A O BOJANCZYK A W | 1991 | IEEE Transactions on Signal Processing1991，39，7： | 1 |
| 3 | Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade显示文摘 | Wu W1 Onn A Isobe T | 2007 | Mol Cancer Ther2007，6，2： | 1 |
| 4 | 显示文摘 | Onn A Levo Y | 1999 | Allergy1999，54，2： | 1 |
| 5 | Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage 1 non-small cell lung cancer 显示文摘 | Onn A Correa A M Gilcrease M etal | 2004 | Clin Cancer Res2004，10，1： | 1 |
| 6 | Angiogenesis and lung cancer: prognostic and therapeutic implications显示文摘 | Herbst RS Onn A Sandler A | 2005 | J Clin Oncol2005，23，14： | 1 |
| 7 | Tumor cavitation in stage I nonsmall cell lung cancer: epidermal growth factor receptor expression and prediction of poor outcome 显示文摘 | Onn A Choe DH Herbst RS | 2005 | Radiology2005，237，1： | 1 |
| 8 | Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a pre?dictor of poor outcome in patients with stage I non-small-cell lung cancer显示文摘 | Onn A Correa AM Gilcrease M | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 9 | Dye coupling between rat striatal neurons recorded in vivo:compartmental organization and modulation by dopamine显示文摘 | Onn S P Grace A A | 1994 | J Neurophysiol1994，71，： | 1 |
| 10 | Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice显示文摘 | Onn A Isobe T Itasaka S | 2003 | Clin Cancer Res2003，9，50： | 1 |
| 11 | Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predic-tot of poor outcome in patients with stage Ⅰ non-small cell lung can-cer显示文摘 | Onn A Correa AM Gilcrease M | 2004 | Clin Cancer Res2004，10，1： | 1 |
| 12 | Current management of abvanced non- small cell lung cancer: targeted therapy 显示文摘 | Isobe T Herbst RS Onn A | 2005 | Semin Oncol2005，32，3： | 1 |
| 13 | Metastatic potential of human neoplasms显示文摘 | Onn A Fidler IJ | 2002 | In Vivo2002，16，6： | 1 |
| 14 | Angiogenesis and lung cancer: prognostic and therapeutic implications 显示文摘 | Herbest RS Onn A Sandier A | 2005 | J Clin Oncol2005，23，： | 1 |
| 15 | Current management of advanced nonsmall cell lung cancer:targeted therapy显示文摘 | Isobe T Herbst RS Onn A | 2005 | Semin Oncol2005，32，3： | 1 |
| 16 | Tumor cavitation in stage I non-small cell lung cancer: epidermal growth factor receptor expression and prediction of poor outcome显示文摘 | Onn A Choe DH Herbst RS | 2005 | Radiology2005，237，1： | 1 |
| 17 | Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer显示文摘 | Onn A Correa A M Gilcrease M | 2004 | Clinical Cancer Research2004，10，1： | 1 |
| 18 | Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer显示文摘 | Onn A Correa A M Gilcrease M | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 19 | Current management of advanced non- small cell lung cancer:targeted therapy显示文摘 | lsobe T Herbst R S Onn A | 2005 | Semin Oncol2005，32，3： | 1 |
| 20 | Existence of hyperbolic singular value decomposi-Tion显示文摘 | Bojanczyk A W Onn R Steinhardt A O | 1993 | Linear Algebra1993，185，： | 1 |
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