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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 3 | Solitary rectal ulcer syndrome presenting as polypoid mass lesions in a young girl显示文摘Solitary rectal ulcer syndrome (SRUS) is a rare condition in children. We report a case of SRUS in an 8-year old Saudi girl who presented with recurrent rectal bleeding,intermittent mucosal prolapse,and passage of mucus per rectum. Colonoscopy revealed multiple polypoid mass lesions with histopathological features of SRUS. The polypoid variant of SRUS is very rare in children and may be confused with rectal malignant or inflammatory conditions. | Omar I Saadah Maram S Al-Hubayshi Ahmad T Ghanem | 2010 | World Journal of Gastrointestinal Oncology2010，2，8： | 2 |
| 4 | Interleukinl β polymorphisms increase risk of hypochlorhydira and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan显示文摘 | Furuta T El- Omar E Xiao F | 2002 | Gastroenterology2002，123，1： | 1 |
| 5 | Interface properties due to microslip from vibration measurement显示文摘 | Sherif H A Omar T M A | 2001 | Journal of Tribology2001，123，1： | 1 |
| 6 | Evaluation of hand function after early excision and skin grafting of burns versus delayed skin grafting a randomized clinical trial显示文摘 | Omar M T Hassan A A | 2011 | Burns2011，37，4： | 1 |
| 7 | Systematic re- view of oncological outcomes following surgical man agement of localised renal cancer显示文摘 | MacLennan S Imanmra M Lapitan M C Omar M I Lain T B Hilvano-Cabungcal A M | 2012 | Eur Urol2012，61，97： | 1 |
| 8 | Cellular transcripts of chicken brain tissues in response to H5N1 and Newcastle disease virus infection显示文摘 | Balasubramaniam V R Wai T H Omar A R | | 0，，： | 1 |
| 9 | Some observations on the interrelationships of potassium and magnesium 显示文摘 | Omar M A El-Kobbia T | 1966 | Soil Science1966，101，6： | 1 |
| 10 | Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts 显示文摘 | WANG B OMAR A ANGELOVSKA T | 2007 | Am J Physiol Heart Circ Physiol2007，293，： | 1 |
| 11 | Metal-organic framework materials with ultrahigh surface areas: is the sky the limit?显示文摘 | Farha Omar K Eryazici Ibrahim Jeong Nak Cheon Hauser Brad G Wilmer Christopher E Sarjeant Amy A Snurr Randall Q Nguyen SonBinh T Ozgox Yazaythn A Hupp Joseph T | 2012 | Journal of the American Chemical Society2012，134，15： | 1 |
| 12 | Removal of Dyes and Industrial Dye Wastes by Magnesium Chloride 显示文摘 | Tan B H Teng T T Omar A K M | 2000 | Water Research2000，34，2： | 1 |
| 13 | Investigation of soil multi-element composition in Antalya,Turkey显示文摘 | NILGUN G OMAR A GMDAL T | 2003 | Environ International2003，10，55： | 1 |
| 14 | Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts显示文摘 | Omar A Angelovska T | 2007 | Am J Physiol Heart Circ Physiol2007，293，2： | 1 |
| 15 | Interface properties due to microslip from vibration measurement显示文摘 | Sherif H A Abu Omar T M | 2001 | ASME Journal of Tribology2001，123，1： | 1 |
| 16 | 显示文摘 | Gonzalez-Munoz M T Omar N B Martinez-Canamero M | 1996 | Journal of Crystal Growth1996，163，： | 1 |
| 17 | 显示文摘 | Omar N B Gonzalez-Munoz M T Penalver J M A | 1998 | Chemosphere1998，36，3： | 1 |
| 18 | Is airway smooth muscle the 'missing link' modulating airway inflammation in asthma显示文摘 | Omar T Yassine A Reynold A | 2008 | Chest2008，133，1： | 1 |
| 19 | Removal of dyes and industrial dye wastes by magnesium chloride显示文摘 | Tan B H Teng T T Omar A K M | 2000 | Wat Res2000，34，2： | 1 |
| 20 | Entanglement of Two Impurities thorough Electron Scattering 显示文摘 | Costa A T Bose S Omar Y | 2006 | Phys Rev Lett2006，96，23： | 1 |
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