|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | Ethylene resistance in flowering ornamental plants – improvements and future perspectives显示文摘Various strategies of plant breeding have been attempted in order to improve the ethylene resistance of flowering ornamental plants. These approaches span from conventional techniques such as simple cross-pollination to new breeding techniques which modify the plants genetically such as precise genome-editing. The main strategies target the ethylene pathway directly;others focus on changing the ethylene pathway indirectly via pathways that are known to be antagonistic to the ethylene pathway, e.g. increasing cytokinin levels. Many of the known elements of the ethylene pathway have been addressed experimentally with the aim of modulating the overall response of the plant to ethylene. Elements of the ethylene pathway that appear particularly promising in this respect include ethylene receptors as ETR1, and transcription factors such as EIN3. Both direct and indirect approaches seem to be successful, nevertheless, although genetic transformation using recombinant DNA has the ability to save much time in the breeding process, they are not readily used by breeders yet. This is primarily due to legislative issues, economic issues, difficulties of implementing this technology in some ornamental plants, as well as how these techniques are publically perceived, particularly in Europe. Recently, newer and more precise genome-editing techniques have become available and they are already being implemented in some crops. New breeding techniques may help change the current situation and pave the way toward a legal and public acceptance if products of these technologies are indistinguishable from plants obtained by conventional techniques. | Andreas Olsen Henrik Lütken Josefine Nymark Hegelund Renate Müller | 2015 | Horticulture Research2015，2，1： | 2 |
| 3 | lntraocular lens power calculation with an improved anterior chamber prediction algorithm 显示文摘 | Olsen T Corydon L Gimbe H | 1995 | J Cataract Refract Surg1995，21，3： | 1 |
| 4 | Sexual identity, sex of sexual con- tacts,and health - risk behaviors among students in grades 9 - 12 - - youth risk behavior surveillance, selected sites, United States, 2001 - - 2009显示文摘 | Kann L Olsen EO McManus T | 2011 | MMWR Surveill Suture2011，60，7： | 1 |
| 5 | Coordinating Production and Delivery under a (z ,Z)-Type Vendor-Man-aged Inventory Contract 显示文摘 | Fry M J Kapuscinski R Olsen T L | 2001 | Manufacturing & Service Operations Management2001，3，2： | 1 |
| 6 | Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling 显示文摘 | Eklund L Olsen BR | 2006 | Exp Cell Res2006，312，5： | 1 |
| 7 | Effects of temperature on the diversity and community structure of known methanogenic groups and other archaeal in high Arctic peat显示文摘 | HΦJ L OLSEN R A TORSVIK V L | 2008 | The ISME Journal2008，2，1： | 1 |
| 8 | Thermoelas- tic properties of ScBz, TiBz, YB4 and HOB4: Ex- perimental and theoretical studies 显示文摘 | Waskowska A Gerward L Olsen J S | 2011 | Aeta Mater2011，59，： | 1 |
| 9 | Elevated circulating levels of copper and nickel are found in elderly subjects with left ventricular hy pertrophy显示文摘 | Lind PM Olsen L Lind L | 2012 | Ecotoxicology and Environmental Safety2012，86，6： | 1 |
| 10 | Risk and short-term prognosis of myocardial infarction among users of antidiabetic drugs显示文摘 | JOHNSEN S P MONSTER T B OLSEN M L | 2006 | Am J Ther2006，13，2： | 1 |
| 11 | Sketch-based modeling:a survey显示文摘 | Olsen L Samavati F F Sousa M C | 2009 | Computers & Graphics2009，33，1： | 1 |
| 12 | Hip fracture risk in statin users-a population-based Danish case-control study 显示文摘 | REJNMARK L OLSEN ML JOHNSEN SP | 2004 | Osteoporos lnt2004，15，： | 1 |
| 13 | Modeling of brazing processes that use coating and interlayers显示文摘 | Liu S Olsen D L Martin G P | 1991 | Welding Journal1991，70，8： | 1 |
| 14 | Cloning of a Salmo salar interleukin-1 receptor-like cDNA显示文摘 | Subramaniam S Stansberg C Olsen L | 2002 | Dev Comp Immunol2002，26，5： | 1 |
| 15 | Serologic evidence ofHI swine Influenza virus infection in swine farm residents andemployees显示文摘 | Olsen CW Brammer L Eastcerday BC | 2002 | Emerg Infect Dis2002，8，8： | 1 |
| 16 | A Lyme bor-reliosis cycle inseabirds and Ixodes uriae ticks显示文摘 | OLSEN B JAENSON T G NOPPA L | 1993 | Nature1993，362，6418： | 1 |
| 17 | The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine显示文摘 | Geenen K Favoreel H W Olsen L | | 0，，： | 1 |
| 18 | A Reverse J-Shaped Association Between Serum 25-Hydroxyvitamin D and Cardiovascular Disease Mortality: The CopD Study显示文摘 | Darshana Durup Henrik L?vendahl J?rgensen Jane Christensen Anne Tj?nneland Anja Olsen Jytte Halkj?r Bent Lind Anne-Marie Heegaard Peter Schwarz | 2015 | The Journal of Clinical Endocrinology & Metabolism2015，，6： | 1 |
| 19 | Explanation for Low-efficiency CuE O Schottky-barrier Solar Cells显示文摘 | Olsen L C Bohara RC Urie M W | 1979 | Applied Physics Letter1979，34，1： | 1 |
| 20 | Elevated cytokine and chemokine levels and prolonged pulmonary air flow resistance in a murine mycoplasma pneumoniae model: a microbiologic, histologic, immunologic, and respiratory plethysmographic profile 显示文摘 | Hardy RD Jarfi HS Olsen K l | 2001 | Ifec and Immun2001，69，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员