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159篇 您的检索式：作者名="Olive DL"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Comparison of in- trauterine insemination with timed intercourse in superovu lated cycles with gonadotropins: a meta-analysis显示文摘	Zeyneloglu HB Arici A Olive DL	1998	Fertil Steril1998，69，3：	1
3	Fibroids and infertility:an upda-ted systematic review of the evidence显示文摘	Pritts EA Parker WH Olive DL	2009	Fertil Steril2009，91，4：	1
4	A call for more trans- parency of registered clinical trials on endometriosis 显示文摘	Guo SW Hnmmelshoj L Olive DL	2009	Hum Reprod2009，24，6：	1
5	Sonohysterography for screening in recurrent pregnancy loss显示文摘	Kehz MD Olive DL Kim AH	1997	Fertil Steril1997，67，4：	1
6	Medical therapy of endometriosis显示文摘	Olive DL	2003	Semi Reprod Med2003，21，2：	1
7	Medical therapy of endometriosis 显示文摘	Olive DL	2003	Semi Reprod Med2003，21，：	1
8	New medical treatments for endometriosis 显示文摘	Olive DL Lindheim SR Pritts EA	2004	Best Pract Res Clin Obstet Gynaecol2004，18，2：	1
9	Fibreids and infertility: an updated systematic review of the evidence 显示文摘	Pritts EA Parker WH Olive DL	2009	Fertil Steril2009，91，4：	1
10	Human trabecular bone cells are able to express both nsteoblastic and adipocytic phenotype:implications for osteopenic disorders显示文摘	Nuttall ME Patton AJ Oliver DL	1998	J Bone Miner Res1998，13，3：	1
11	显示文摘	Oliver JM Burg DL Wilson BS	1994	J Biol Chem1994，269，29：	1
12	Endometriosis显示文摘	Olive DL Sohwartz LB	1993	N Engl Med1993，328，24：	1
13	Comparison of intrauterine insemination with timed intercourse in superovulated cycles with gonadotropins:a meta-analysis显示文摘	Zeyneloglu HB Arici A Olive DL	1998	Fertil Steril1998，69，3：	1
14	A sex steroids mediate Hoxa11 expression in the human peri-implantation endometrium显示文摘	Taylor HS Igarashi P Olive DL	1999	J Clin Endocrinol Metab1999，84，3：	1
15	The surgical treatment of fibroids for infertility 显示文摘	Olive DL	2011	Semin Reprod Med2011，29，2：	1
16	Treatment of endometriosis显示文摘	Olive DL Pritts EA	2001	N Engl JMed2001，345，4：	1
17	Sonohysterography for screening in recurrent pregnancy loss 显示文摘	Keltz MD Olive DL Kim AH	1997	Fertil Steril1997，67，4：	1
18	Changing hysterectomy patterns after introduction of laparoscopically assisted vaginal hysterectomy显示文摘	Harris MB Olive DL	1994	Am J Obstet Gynecol1994，171，2：	1
19	Sex steroids mediate HOXA-11 expression in the human peri-implantation endometrium显示文摘	Taylor HS Igarshi P Olive DL	1999	J Clin Endocrinol Metab1999，84，：	1
20	The surgical treatment of fibroids for infertility 显示文摘	Olive DL	2011	29(2) : 113 -1232011，29，2：	1

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