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| 1 | Circulating micro RNA, mi R-122 and mi R-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma显示文摘AIM: To explore the potential usefulness of serum miR-122 and miR-221 as non-invasive diagnostic markers of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS: This prospective study was conducted on 90 adult patients of both sex with HCV-related chronic liver disease and chronic hepatitis C related HCC. In addition to the 10 healthy control individuals, patients were stratified into; interferon-na?ve chronic hepatitis C(CH)(n = 30), post-hepatitis C compensated cirrhosis(LC)(n = 30) and treatment-naive HCC(n = 30). All patients and controls underwent full clinical assessment and laboratory investigations in addition to the evaluation of the level of serum miR NA expression by RT-PCR.RESULTS: There was a significant fold change in serum mi RNA expression in the different patient groups when compared to normal controls; mi R-122 showed significant fold increasing in both CH and HCC and significant fold decrease in LC. On the other hand, mi R-221 showed significant fold elevation in both CH and LC groups and significant fold decrease in HCC group(P = 0.01). Comparing fold changes in miR NAs in HCC group vs non HCC group(CH and Cirrhosis), there was non-significant fold elevation in miR-122(P = 0.21) and significant fold decreasing in miR-221 in HCC vs non-HCC(P = 0.03). ROC curve analysis for miR-221 yielded 87% sensitivity and 40% specificity for the differentiation of HCC patients from non-HCC at a cutoff 1.82. CONCLUSION: Serum miR-221 has a strong potential to serve as one of the novel non-invasive biomarkers of HCC. | Hassan El-Garem Ayman Ammer Hany Shehab Olfat Shaker Mohammed Anwer Wafaa El-Akel Heba Omar | 2014 | World Journal of Hepatology2014，6，11： | 18 |
| 2 | Phase II Trial: Undifferentiated Versus Differentiated Autologous Mesenchymal Stem Cells Transplantation in Egyptian Patients with HCV Induced Liver Cirrhosis显示文摘 | Mervat El-Ansary Iman Abdel-Aziz Sherif Mogawer Samah Abdel-Hamid Olfat Hammam Salwa Teaema Marwa Wahdan | 2012 | Stem Cell Reviews and Reports2012，，3： | 4 |
| 3 | Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4–infected Children显示文摘 | Olfat G. Shaker Yasser H. Nassar Zeinab A. Nour Mona El Raziky | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，2： | 3 |
| 4 | Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis显示文摘Objective:To investigate the antifibrotic role of rosmarinic acid(RA),a natural polyphenolic compound,on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods:The impact of RA on stellate cell line(HSC-T6) proliferation,activation and apoptosis was assessed along with its safety on primary hepatocytes. In vivo,rats were divided into:(i) normal;(ii) thioacetamide(TAA)-intoxicated rats for 12 weeks;(iii) TAA+silymarin or(iv) TAA+RA. At the end of experiment,liver functions,oxidative stress,inflammatory and profibrogenic markers,tissue inhibitor metalloproteinases type-1(TIMP-1) and hydroxyproline(HP) levels were evaluated. Additionally,liver histopathology and immunohistochemical examinations of alpha-smooth muscle actin(α-SMA),caspase-3 and proliferation cellular nuclear antigen(PCNA) were determined. Results:RA exhibited anti-proliferative effects on cultured HSCs in a time and concentration dependent manner showing an IC50 of 276 μg/mL and 171 μg/mL for 24 h and 48 h,respectively,with morphological reversion of activated stellate cell morphology to quiescent form. It significantly improved ALT,AST,oxidative stress markers and reduced TIMP-1,HP levels,inflammatory markers and fibrosis score(S1 vs S4). Furthermore,reduction in α-SMA plus elevation in caspase-3 expressions of HSCs in vitro and in vivo associated with an inhibition in proliferation of damaged hepatocytes were recorded. Conclusions:RA impeded the progression of liver fibrosis through inhibition of HSCs activation/proliferation and induction of apoptosis with preservation of hepatic architecture. | Naglaa M.El-Lakkany Walaa H.El-Maadawy Sayed H.Seif el-Din Olfat A.Hammam Salwa H.Mohamed Shahira M.Ezzat Marwa M.Safar Samira Saleh | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，5： | 2 |
| 5 | Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC显示文摘 | Mervat El Ansary Sherif Mogawer Samah Abd Elhamid Sahr Alwakil Fatma Aboelkasem Hatem El Sabaawy Olfat Abdelhalim | 2013 | Journal of Cancer Research and Clinical Oncology2013，，： | 2 |
| 6 | Differential MicroRNAs Expression in Serum of Patients with Lung Cancer, Pulmonary Tuberculosis, and Pneumonia显示文摘 | Amal A. Abd-El-Fattah Nermin Abdel Hamid Sadik Olfat Gamil Shaker Mariam Lotfy Aboulftouh | 2013 | Cell Biochemistry and Biophysics2013，，3： | 2 |
| 7 | Role of sulfurous mineral water and sodium hydrosulfide as potent inhibitors of fibrosis in the heart of diabetic rats显示文摘 | Mohamed M. El-Seweidy Nermin A.H. Sadik Olfat G. Shaker | 2010 | Archives of Biochemistry and Biophysics2010，，1： | 1 |
| 8 | P53 rs1042522 and CD95 rs1800682 genetic variations in HCV-4a response to antiviral therapy显示文摘Current estimates indicate that the hepatitis C(HCV)is the leading cause of mortality around the world,with infection rates steadily increasing in Egypt.The dual therapy for this silent epidemic with pegylated-interferon-a2b/ribavirin has markedly improved the success rates in genotype-4 patients.It was reported that apoptosis plays a vital mechanistic role in limiting viral replication.P53,a key regulator of apoptosis,induces CD95 gene expression and subsequently initiates apoptotic cascade to be activated.The current study examined the impact of P53 rs1042522 and CD95 rs1800682 polymorphisms on the treatment response.Three groups of 240 volunteers were enrolled in this study;86 in sustained virological responders group,74 in non-responders group,and 80 in control group.All patients had HCV genotype-4a and were interferon treatment naı¨ve.Quantizations of HCV-RNA by qRT-PCR and histological scores were performed for all patients.In addition,genotyping of HCV-RNA,P53 rs1042522 Arg/Pro and CD95 rs1800682 A/G polymorphisms were investigated in all subjects.It was resulted that P53 Pro/Pro homozygous genotype has high significant increase,while CD95 A/A homozygous genotype has high significant decrease when comparing non-responders with responders.Finally,it was concluded that Pro variant of P53 rs1042522 may be used as a genetic predictor for non-responsiveness,while A/A variant of CD95 rs1800682 may be used as a sensitive biomarker for responsiveness to antiviral therapy of HCV genotype-4a infection.In addition,low prolactin,high total testosterone,and high GH levels may provide promising biomarkers for early prediction of the response when associated with these genetic polymorphisms. | Ahmed A.Abd-Rabou Emad F.Eskander Mervat S.Mohamed Shaymaa M.M.Yahya Ashraf El Sherbini Olfat G.Shaker | 2015 | Genes & Diseases2015，2，2： | 1 |
| 9 | Obtaining fulldiversity space-frequency codes from space-time codes via mapping显示文摘 | W F Su Z Safar M Olfat K J Ray Liu | 2003 | IEEE Trans Signal processing2003，51，11： | 1 |
| 10 | Multiband- OFDM MIMO Coding Framework for UWB Communication Systems 显示文摘 | PAIRAT W P SU Wei-feng OLFAT M | 2006 | IEEE Transactions on Signal Processing2006，54，1： | 1 |
| 11 | Flocking for multi-agent dynamic systems: algorithms and theory显示文摘 | OLFATIC SABER R | 2006 | Th IEEE Transactions on Auto- matic Control2006，51，3： | 1 |
| 12 | Effect of terrain on foot pressures during walking显示文摘 | Olfat Mohamed | 1999 | J Biomech1999，18，： | 1 |
| 13 | A new signal subspace processing for DOA estimation显示文摘 | OLFAT A | 2004 | Signal Processing2004，84，4： | 1 |
| 14 | Recursive Construction of 16-QAM Super- Golay Codes for OFDM Systems 显示文摘 | Olfat M Liu K J R | 2003 | IEEE International Conference on Communications2003，，5： | 1 |
| 15 | Power allocation for OFDM using adaptive beamforming over wireless networks 显示文摘 | OLFAT M FARROKHI F R LIU K J R | 2005 | IEEE Transactions on Communications2005，53，3： | 1 |
| 16 | Integration of cadastral survey data into building information models显示文摘Cadastral surveying plays an important role in defining legal boundaries of land and property.The current practice for recording cadastral survey data mainly relies on 2D digital or analog documents.This practice is efficient for simple land parcels but can be challenged in complex building developments.To address the issues stemmed from 2D methods of representing cadastral survey data,3D spatial information models can be considered as a viable solution for managing cadastral survey data.Building Information Modeling(BIM)enables colsslaborative 3D management of the design,construction,and operation of buildings.There have been extensive studies conducted to investigate the connectivity between BIM and 3D cadaster.Most of these studies focus on managing legal information,such as ownership boundaries and attributes,in BIM-based environments.However,there is limited investigation on how survey-ing measurements can be mapped into BIM.In this study,the proposed method for integrating the cadastral survey data into the BIM environment includes identifying cadastral survey requirements,using BIM entities relevant to cadastral survey data,enrichment of a BIM proto-type,and evaluation of the prototype.The major contribution of this study is to demonstrate the storage of cadastral survey data such as survey marks and traverse lines in the BIM environment.Therefore,this research contributes to the further enrichment of BIM with incorporating data elements related to cadastral surveying practices.It is confirmed that current BIM-based tools provide restricted capabilities for explicit management and visualiza-tion of cadastral survey data.This limitation can be addressed in the future enhancements of BIM in terms of supporting important elements for cadastral survey data. | Behnam Atazadeh Leila Halalkhor Mirkalaei Hamed Olfat Abbas Rajabifard Davood Shojaei | 2021 | Geo-Spatial Information Science2021，24，3： | 1 |
| 17 | Low peak to average power ratio cyclic Golay sequences for OFDM Systems显示文摘 | Olfat M Liu K J R | 2004 | IEEE Communication Society2004，2，20： | 1 |
| 18 | Vaspin gene in rat adipose tissue: relation to obesity-induced insulin resistance显示文摘 | Olfat G. Shaker Nermin Abdel Hamid Sadik | 2013 | Molecular and Cellular Biochemistry2013，，1： | 1 |
| 19 | Effect of terrain on foot pressures during walking显示文摘 | OLFAT M KAY C LILY H | 2000 | Diabetes Care2000，22，： | 1 |
| 20 | Recursive construction of 16-QAM super-Golay codes for OFDM systems显示文摘 | OLFAT M LIU K J R | 2003 | IEEE International Conference on Communications2003，5，： | 1 |
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