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| 1 | Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells显示文摘Enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and-4(PFKFB-3 and PFKFB-4)play a significant role in the regulation of glycolysis in cancer cells as well as its proliferation and survival.The expression of these mRNAs is increased in malignant tumors and strongly induced in different cancer cell lines by hypoxia inducible factor(HIF)through active HIF binding sites in promoter region of PFKFB-4 and PFKFB-3 genes.Moreover,the expression and hypoxia responsibility of PFKFB-4 and PFKFB-3 was also shown for pancreatic(Panc1,PSN-1,and MIA PaCa-2)as well as gastric(MKN45 and NUGC3)cancer cells.At the same time,their basal expression level and hypoxia responsiveness vary in the different cells studied:the highest level of PFKFB-4 protein expression was found in NUGC3 gastric cancer cell line and lowest in Panc1 cells,with a stronger response to hypoxia in the pancreatic cancer cell line.Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is correlated with enhanced expression of vascular endothelial growth factor(VEGF)and Glut1 mRNA as well as with increased level of HIF-1αprotein.Increased expression of different PFKFB genes was also demonstrated in gastric,lung,breast,and colon cancers as compared to corresponding nonmalignant tissue counterparts from the same patients,being more robust in the breast and lung tumors.Moreover,induction of PFKFB-4 mRNA expression in the breast and lung cancers is stronger than PFKFB-3mRNA.The levels of both PFKFB-4 and PFKFB-3 proteins in non-malignant gastric and colon tissues were more pronounced than in the non-malignant breast and lung tissues.It is interesting to note that Panc1and PSN-1 cells transfected with dominant/negative PFKFB-3(dnPFKFB-3)showed a lower level of endogenous PFKFB-3,PFKFB-4,and VEGF mRNA expressions as well as a decreased proliferation rate of these cells.Moreover,a similar effect had dnPFKFB-4.In conclusion,there is strong evidence that PFKFB-4 and PFKFB-3 isoenzymes are induced under hypoxia in pancreatic and other cancer cell lines,are overexpressed in gastric,colon,lung,and breast malignant tumors and undergo changes in their metabolism that contribute to the proliferation and survival of cancer cells.Thus,targeting these PFKFB may therefore present new therapeutic opportunities. | Oleksandr H Minchenko Katsuya Tsuchihara Dmytro O Minchenko Andreas Bikfalvi Hiroyasu Esumi | 2014 | World Journal of Gastroenterology2014，20，38： | 17 |
| 2 | Crosstalk between gut microbiota and antidiabetic drug action显示文摘Type 2 diabetes (T2D) is a disorder characterized by chronic inflated blood glucose levels (hyperglycemia), at first due to insulin resistance and unregulated insulin secretion but with tendency towards global spreading. The gut microbiota is recognized to have an influence on T2D, although surveys have not formed a clear overview to date. Because of the interactions between gut microbiota and host homeostasis, intestinal bacteria are believed to play a large role in various diseases, including metabolic syndrome, obesity and associated disease. In this review, we highlight the animal and human studies which have elucidated the roles of metformin,α-glucosidase inhibitors, glucagon-like peptide-1 agonists, peroxisome proliferator-activated receptors γ agonists, inhibitors of dipeptidyl peptidase-4, sodium/glucose cotransporter inhibitors, and other less studied medications on gut microbiota. This review is dedicated to one of the most widespread diseases, T2D, and the currently used antidiabetic drugs and most promising new findings. In general, the gut microbiota has been shown to have an influence on host metabolism, food consumption, satiety, glucose homoeostasis, and weight gain. Altered intestinal microbiota composition has been noticed in cardiovascular diseases, colon cancer, rheumatoid arthritis, T2D, and obesity. Therefore, the main effect of antidiabetic drugs is on the microbiome composition, basically increasing the short-chain fatty acids-producing bacteria, responsible for losing weight and suppressing inflammation. | Yevheniia Kyriachenko Tetyana Falalyeyeva Oleksandr Korotkyi Nataliia Molochek Nazarii Kobyliak | 2019 | World Journal of Diabetes2019，10，3： | 9 |
| 3 | 电磁旋流水口连铸技术对小方坯凝固组织形貌和宏观偏析的影响显示文摘在不同工业实验条件下,研究了电磁旋流水口技术对小方坯的凝固组织和C、S元素宏观偏析特征的影响规律,并与结晶器电磁搅拌所得结果相比较。结果表明,仅用电磁旋流水口技术,在电流频率为50 Hz时,随着电流强度由200 A升至600 A,等轴晶逐渐增多,而中心偏析严重程度先减轻后加重,在凝固组织以细小柱状晶为主时出现最优值。研究还表明,可以通过调整电磁旋流装置的电流参数来改变浸入式水口内钢水的旋流强度,进而获得不同凝固组织形貌和宏观偏析严重程度的铸坯。在本实验条件下,当装置的电流参数达到一定值后,电磁旋流水口技术在提高铸坯质量方面可以达到与结晶器电磁搅拌相同甚至更优的效果。 | 吴春雷 李德伟 朱晓伟 王强 Oleksandr Tretiak 雷洪 | 2019 | 金属学报2019，55，7： | 7 |
| 4 | 耐磨铸铁研究现状与发展趋势显示文摘从耐磨铸铁的分类、发展历程、现行标准、性能特征、磨损性能影响因素、典型应用等方面论述了国内外耐磨铸铁的研究现状与进展,重点介绍了化学成分、基体组织、热处理工艺和碳化物对耐磨铸铁磨损性能的影响,提出了耐磨铸铁存在韧性低、成本高等问题,以及低成本无镍化,建立理论模型,ZrO2作为形核剂,新型复合碳化物等今后研究方向的建议。 | 郑欢 胡锋 ISAYEV Oleg HRESS Oleksandr YERSHOV Serhii 吴开明 | 2020 | 钢铁研究学报2020，32，9： | 6 |
| 5 | Analysis of Efficiency of the Ship Propulsion System with Thermochemical Recuperation of Waste Heat显示文摘One of the basic ways to reduce polluting emissions of ship power plants is application of innovative devices for on-board energy generation by means of secondary energy resources.The combined gas turbine and diesel engine plant with thermochemical recuperation of the heat of secondary energy resources has been considered.It is suggested to conduct the study with the help of mathematical modeling methods.The model takes into account basic physical correlations,material and thermal balances,phase equilibrium,and heat and mass transfer processes.The paper provides the results of mathematical modeling of the processes in a gas turbine and diesel engine power plant with thermochemical recuperation of the gas turbine exhaust gas heat by converting a hydrocarbon fuel.In such a plant,it is possible to reduce the specific fuel consumption of the diesel engine by 20%.The waste heat potential in a gas turbine can provide efficient hydrocarbon fuel conversion at the ratio of powers of the diesel and gas turbine engines being up to 6.When the diesel engine and gas turbine operate simultaneously with the use of the LNG vapor conversion products,the efficiency coefficient of the plant increases by 4%–5%. | Oleksandr Cherednichenko Serhiy Serbin | 2018 | Journal of Marine Science and Application2018，17，1： | 5 |
| 6 | The impact of macroeconomic uncertainty on non-financial firms’ demand for liquidity显示文摘 | Christopher F. Baum Mustafa Caglayan Neslihan Ozkan Oleksandr Talavera | 2006 | Review of Financial Economics2006，，4： | 3 |
| 7 | Balanced scorecard-based analysis of customer expectations for cosmetology services:a hybrid decision modeling approach显示文摘The goal of this study is to analyze and characterize customer expectations in the cosmetics sector.Within this framework,first,the extant literature is reviewed,and 12 most prominent performance measurement criteria are identified.Then,these criteria are organized along the four different balanced scorecard dimensions.By employing an Interval Type-2 Fuzzy DEMATEL methodology,the weighted importance of these dimensions and criteria are identified.Additionally,with the Interval Type-2 Fuzzy TOPSIS approach,13 leading cosmetic service providers in Ukraine are ranked based on their relative scores.The findings of the study indicate that consumer is the most significant dimension while learning and growth seem to have the least importance.Similarly,it is also concluded that all consumerfocused criteria(i.e.diversification of services,feedback on the product and services,and customer loyalty)have the highest priorities in the complete criterion set. | Dursun Delen Oleksandr Dorokhov Liudmyla Dorokhova Hasan Dincer Serhat Yüksel | 2020 | Journal of Management Analytics2020，7，4： | 3 |
| 8 | Realizing ultra-pure red emission with Sn-based lead-free perovskites显示文摘Light-emitting diodes(LEDs)are key for the development of next-generation displays for ultra-high-definition television.Alternative materials beyond organic LEDs are required to meet the color purity standards,while retaining low processing cost and environmental friendliness.Liang and colleagues report in Advanced Science that two-dimensional(2D)tin halide perovskite—efficiently stabilized by H3PO2 incorporation—has great promise for ultra-pure red LEDs. | Oleksandr Voznyy | 2020 | Rare Metals2020，39，4： | 2 |
| 9 | 废热热化学回收对气体运输船能效的影响分析显示文摘Enlarging the fleet of gas carriers would make it possible to respond to the growing demand for hydrocarbon gases,but it will increase carbon dioxide emissions.The International Maritime Organization(IMO)has developed the energy efficiency design index(EEDI)with the objective of carbon emission reduction for new ships.In this paper,thirty gas carriers transporting liquefied natural gas(LNG)and liquefied petroleum gas(LPG)and equipped with various types of main engines are considered.As shown by the calculation of the attained EEDI,2 of the 13 LPG carriers and 6 of the 17 LNG carriers under study do not comply with the EEDI requirements.To meet the stringent EEDI requirements,applying thermochemical regenerators(TCRs)fed by main engine exhaust gases is suggested.Mathematical modeling is applied to analyze the characteristics of the combined gas-turbine-electric and diesel-electric power plant with thermochemical recuperation of the exhaust gas heat.Utilizing TCR on gas carriers with engines fueled by syngas produced from boil-off gas(BOG)reduces the carbon content by 35%and provides the energy efficiency required by IMO without the use of other technologies. | Oleksandr Cherednichenko Vira Mitienkova | 2020 | Journal of Marine Science and Application2020，19，1： | 2 |
| 10 | T-SPLINE开源内核的三层数据结构及算法原理显示文摘针对T-SPLINE开源内核,论述了T样条三层数据结构及相关算法原理,以帮助使用者更快更好地掌握和应用T-SPLINE开源内核的使用方法.首先介绍T-SPLINE开源内核及三层数据结构,论述该数据结构对T样条计算与存储的高效性;然后根据三层数据结构的特点设计了一系列高效的算法,主要包括面内节点初始化算法、关键参数抽取算法、高效基函数计算算法、重节点管理算法等,并详细说明了上述算法的原理;最后对T-SPLINE开源内核的时间复杂度和空间复杂度进行了分析与验证.实验证明,T-SPLINE开源内核在时间空间复杂度上具有一定的优势. | 肖文磊 刘亚醉 Oleksandr Zavalnyi 赵罡 | 2017 | 计算机辅助设计与图形学学报2017，29，11： | 2 |
| 11 | Selection and application of soft-ware testing techniques to specific conditions of softwareprojects 显示文摘 | Othmar M Oleksandr L | 2013 | International Journal of Computer Applica-tions2013，70，18： | 1 |
| 12 | Reduction of Listeria monocytogenes on frankfurters treated with lactic acid solutions of various temperatures显示文摘 | BYELASHOV OLEKSANDR A DASKALOV HRISTO GEORNARAS IFIGENIA | 2010 | Food Microbiology2010，27，： | 1 |
| 13 | Restructuring,productivity and technical efficiency in China's iron and steel industry,1988-2000显示文摘 | OLEKSANDR MOVSHUK | 2004 | Journal of Asian Economies2004，，15： | 1 |
| 14 | A simple parallelization technique with MPI for ocean circulation models 显示文摘 | Oleksandr Nesterov | 2010 | J ParaUel Distrib Comput2010，70，1： | 1 |
| 15 | The Structure of Conscientiousness an Empirical Investigation Based on Seven Major Personality Questionnaires显示文摘 | ROBERTS BRENT W CHERNYSHENKO OLEKSANDR S STARK S | 2005 | Personnel Psychology2005，58，1： | 1 |
| 16 | The effect of content of apple juice biopolymers on the concentration by membrane distillation 显示文摘 | Oleksandr S Lukanin Sergiy M Gunko Mikhaylo T Bryk | 2003 | Journal of Food Engineering2003，60，3： | 1 |
| 17 | Quantization error of CCD cameras and their influence on phase calculation in fringe pattern analysis显示文摘 | Oleksandr A Skydan Francis Lilley Michael J Lalor | 2003 | Optical Society of Amerian2003，42，26： | 1 |
| 18 | Mitochondrial processing peptidases 显示文摘 | Oleksandr G Patrizia C Grazia I | 2002 | Biochim Biophy Acta2002，1592，1： | 1 |
| 19 | Restructuring, Productivity and Technical Efficiency in China' s Steel Industry, 1988 - 2000 显示文摘 | Oleksandr Movshuk | 2004 | Journal of Asian Economics2004，，15： | 1 |
| 20 | Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation 显示文摘 | Michele S Ying Y Oleksandr P | 2002 | Am J Physiol Lung Cell Mol Physiol2002，283，： | 1 |
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