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| 1 | Bacterial entombment by intratubular mineralization following orthograde mineral trioxide aggregate obturation: a scanning electron microscopy study显示文摘The time domain entombment of bacteria by intratubular mineralization following orthograde canal obturation with mineral trioxide aggregate(MTA) was studied by scanning electron microscopy(SEM). Single-rooted human premolars(n560) were instrumented to an apical size #50/0.06 using ProF ile and treated as follows: Group 1(n510) was filled with phosphate buffered saline(PBS); Group 2(n510) was incubated with Enterococcus faecalis for 3 weeks, and then filled with PBS; Group 3(n520) was obturated orthograde with a paste of OrthoM TA(BioM TA, Seoul, Korea) and PBS; and Group 4(n520) was incubated with E. faecalis for 3 weeks and then obturated with OrthoM TA–PBS paste. Following their treatments, the coronal openings were sealed with PBS-soaked cotton and intermediate restorative material(IRM), and the roots were then stored in PBS for 1, 2, 4, 8 or 16 weeks. After each incubation period, the roots were split and their dentin/MTA interfaces examined in both longitudinal and horizontal directions by SEM. There appeared to be an increase in intratubular mineralization over time in the OrthoM TA-filled roots(Groups 3 and 4). Furthermore, there was a gradual entombment of bacteria within the dentinal tubules in the E. faecalis inoculated MTA-filled roots(Group 4). Therefore, the orthograde obturation of root canals with OrthoM TA mixed with PBS may create a favorable environment for bacterial entombment by intratubular mineralization. | Jun Sang Yoo Seok-Woo Chang So Ram Oh Hiran Perinpanayagam Sang-Min Lim Yeon-Jee Yoo Yeo-Rok Oh Sang-Bin Woo Seung-Hyun Han Qiang Zhu Kee-Yeon Kum | 2014 | International Journal of Oral Science2014，6，4： | 5 |
| 2 | Plasmid DNA-loaded asymmetrically porous membrane for guided bone regeneration显示文摘Although bone defects can be restored spontaneously,bone reconstruction with sufficient strength and volume continues to be a challenge in clinical practices.In recent years,the use of a variety of biomaterials with bioactivity has been attempted to compensate for this limitation.Herein,we fabricated a pDNA(encoding for BMP-2)-loaded asymmetrically porous polycaprolactone(PCL)/Pluronic F127 membrane as a bioactive guided bone regeneration(GBR)membrane,using a modified immersion-precipitation method.It was observed that the GBR membrane allows continuous release of pDNA for more than20 weeks.The pDNA was sufficiently transfected into human bone marrow stem cells(h BMSCs)without significant cytotoxicity and the gene-transfected cells showed prolonged synthesis of BMP-2.From in vitro osteogenic differentiation and in vivo animal studies,the effective induction of osteogenic differentiation of h BMSCs and enhanced bone regeneration by the pDNA-loaded asymmetrically porous PCL/Pluronic F127 membrane was observed,suggesting that the pDNA-loaded membrane as a bioactive GBR membrane can be an alternative therapeutic technique for effective bone regeneration. | Se Heang Oh June-Ho Byun So Young Chun Young-Joo Jang Jin Ho Lee | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 3 | Cisplatin ototoxicity involves cytokines and STAT6 signaling network显示文摘我们此处调查了在支持 inflammatory cytokines 和 cisplatin ototoxicity 的生产表明串联的 STAT 的角色。cisplatin 注射引起的一个重要听觉缺陷在 Balb/c 被观察(野类型, WT ) 并且 STAT4 −/−, 然而并非在 STAT6 −/− 老鼠。而且,蛋白质的表示层次和支持 inflammatory cytokines 的 mRNA,包括 TNF-α, IL-1β,并且 IL-6,显著地在 WT 和 STAT4 −/−, 然而并非 STAT6 −/− 老鼠的浆液和蜗被增加。Organotypic 文化表明 stereocilia 捆的形状和在从 STAT6 −/− 鼠标的 Corti 的机关的感觉毛细胞层的数组在有 cisplatin 的处理以后是未经触动的,而那些高度在处理以后从 WT 和 STAT4 −/− 鼠标被弄歪并且弄乱。Cisplatin 在 HEI-OC1 听觉的房间导致了 STAT6 的 phosphorylation,并且由显著地保护的 STAT6 特定的 siRNA 的 STAT6 击倒从导致 cisplatin 的房间死亡的 HEI-OC1 听觉的房间和禁止的支持 inflammatory cytokine 生产。我们进一步证明 cisplatin 导致的 IL-4 和 IL-13 与 IL-4 受体 alpha 和 IL-13Rα 由绑定调制了 STAT6 的 phosphorylation; 1。这些调查结果建议发信号的 STAT6 在调停 cisplatin 的支持 inflammatory cytokine 生产和 ototoxicity 起一个枢轴的作用。 | Hyung-Jin Kim Gi-Su Oh Jeong-Han Lee Ah-Ra Lyu Hye-Min Ji Sang-Heon Lee Jeho Song Sung-Joo Park Yong-Ouk You Jeong-Dug Sul Channy Park Sang-Young Chung Sung-Kyun Moon David J Lim Hong-Seob So Raekil Park | 2011 | Cell Research2011，21，6： | 2 |
| 4 | uPAR expression under hypoxic conditions depends on iNOS modulated ERK phosphorylation in the MDA-MB-231 breast carcinoma cell line显示文摘尿激 plasminogen 使活跃之物受体(uPAR ) 戏在癌症侵略和转移和 uPAR 表示的一个主要角色在各种各样的癌症类型与差的预后被相关。而且, uPAR 的表示在 hypoxic 条件下面被增加。氮的氧化物(没有) 并且它可诱导的氮的氧化物 synthase (i NOS ) 生产的代谢物是 hypoxic 应力的重要产品,并且可以不激活或调制细胞外的信号调整 kinase (英皇家空军之阶级最低之兵) 。这里,我们在 MDA-MB-231 人的乳癌房间线在 hypoxic 条件,和 i NOS 并且不的调节效果下面在 A, uPAR,和激活的英皇家空军之阶级最低之兵层次上面评估了。房间在 hypoxic 或 normoxic 孵卵器被孵化并且与 PD98059 对待(一个 MEK 1/2 禁止者,它废除英皇家空军之阶级最低之兵 phosphorylation ) 并且 aminoguanidine (选择 i NOS 禁止者) 。uPAR 表示,英皇家空军之阶级最低之兵 phosphorylation,并且在 A 上面,活动被发现在 hypoxic 条件下面被增加。而且当房间在 hypoxic 条件下面与 PD98059 被对待时, uPAR 低调整,而 aminoguanidine 显著地以一种剂量依赖者方式增加了英皇家空军之阶级最低之兵 phosphorylation。而且, aminoguanidine 增加了 uPAR 表示并且由 PD98059 阻止了 uPAR 表示的抑制。这些结果证明 uPAR 被组织缺氧导致,那增加的 uPAR 表情被英皇家空军之阶级最低之兵 phosphorylation 调停,它被 iNOS/NO 接着在 MDA-MB-231 房间调制。我们结束那 iNOS/NO 在下面经由英皇家空军之阶级最低之兵小径调整在 hypoxic 条件下面调整 uPAR 的表示。 | So Young Yoon Yoo Jung Lee Jae Hong Seo Hwa Jung Sung Kyong Hwa Park In Keun Choi Seok Jin Kim Sang Cheul Oh Chul Won Choi Byung Soo Kim Sang Won Shin Yeul Hong Kim Jun Suk Kim | 2006 | Cell Research2006，16，1： | 2 |
| 5 | Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial显示文摘BACKGROUND Increasing levels of antibiotic resistance have reduced the Helicobacter pylori(H.pylori)eradication rates afforded by the standard triple therapy.Thus,2-wk firstline four-drug regimens must be considered.AIM To analyze the eradication rates of modified bismuth-containing quadruple therapy(mBCQT)and concomitant therapy(CT),the associated adverse events,and compliance.METHODS Patients infected with H.pylori were prospectively randomized to receive mBCQT or CT for 2 wk.mBCQT featured a proton pump inhibitor(PPI),bismuth,metronidazole,and tetracycline,taken twice daily.CT included a PPI,clarithromycin,metronidazole,and amoxicillin,taken twice daily.The 13C-urea breath test was performed no earlier than 4 wk after therapy concluded to confirm eradication.If either the histological or rapid urease test was positive,H.pylori infection was diagnosed.RESULTS The demographic characteristics of 68 patients who received mBCQT and 68 who received CT did not differ significantly.On intention-to-treat analysis,the eradication rate was 88.2%(60/68)in the mBCQT group and 79.4%(54/68)in the CT group(P=0.162).By per-protocol analysis,the respective eradication rates were 98.4%(60/61)and 93.1%(54/58)(P=0.199).More CT than mBCQT patients experienced adverse events[33.8%(23/68)mBCQT vs 51.5%(35/58)CT patients,respectively,P=0.037].All patients showed good compliance[85.3%(58/68)mBCQT vs 82.4%(56/68)CT patients,P=0.641].CONCLUSION The H.pylori eradication rates of the 2-wk mBCQT and CT regimens are high.Most patients show good compliance,and more CT than mBCQT patients experience adverse events. | So Jeong Kim Jun-Won Chung Hyun Sun Woo Su Young Kim Jung Ho Kim Yoon Jae Kim Kyoung Oh Kim Kwang An Kwon Dong Kyun Park | 2019 | World Journal of Gastroenterology2019，25，46： | 2 |
| 6 | Schottky Diodes Based on a Single GaN Nanowire显示文摘 | Jae-Ryoung Kim Hwangyou Oh Hye Mi So | 2002 | Institute of Physics Publishing Nanotecnology2002，13，： | 1 |
| 7 | Induction of early flowering in Cymbidium niveo-marginatum Mak in vitro显示文摘 | Kostenyuk I Oh B J So I S | 1999 | Plant Cell Reports1999，，19： | 1 |
| 8 | Effects of mitomycin C on delayed adjustment in experimental strabismus surgery显示文摘 | Oh SO Chang BL Lee J | 1995 | Korean J Ophthalmol1995，9，1： | 1 |
| 9 | Bacillus subtilis S1-0210 as a bio-control agent againstBotrytis cinereain strawberries显示文摘 | HANG NTT OH SO KIM GH | 2005 | Plant Pathol J2005，21，1： | 1 |
| 10 | A Rapid Method for RNA Preparation from Grampositive Bacteria显示文摘 | OH E T SO J S | 2003 | J Microbiol Methods2003，52，3： | 1 |
| 11 | Use of protease produced byBacillus sp. SJ-121 for improvement of dyeing quality in wool and silk显示文摘 | Soo-Jin Kim Min-Kyoung Cha Eun Taex Oh Sang-Mo Kang Jae-Seong So Yoon-Jung Kwon | 2005 | Biotechnology and Bioprocess Engineering2005，，3： | 1 |
| 12 | Preparation of silica dispersion and its phase stability in the presence of salts显示文摘 | Oh M H So J H Lee J D | 1999 | Korean Journal of Chemical Engineering1999，16，4： | 1 |
| 13 | Bioconversion of linoleic acid into con- jugated linoleic acid by immobilized Lactobaeillus reuteH显示文摘 | LEE SO HONG GW OH DK | 2003 | Biotech- nol Prog2003，19，3： | 1 |
| 14 | Induction of early flowering in Cymbidium niveo-marginatum Mark in vitro显示文摘 | Oh BJ So IS | 1999 | Plant cell Reports1999，，19： | 1 |
| 15 | Association of HLA-DR and type II collagen autoimm unity with Menieres disease 显示文摘 | Koo JW Oh SH Chang SO | 2003 | Tissue Anti- gen2003，61，1： | 1 |
| 16 | , Robust tests for unit roots in heterogeneous panels 显示文摘 | Yu Jin Oh Beong Soo So | 2004 | Economics Letters2004，3541，： | 1 |
| 17 | Reduction of postoperative adhesions in strabismus surgery显示文摘 | Oh SO Lee J | 1992 | Korean J Ophthalmol1992，6，2： | 1 |
| 18 | Induction of early flowering in Cymbidiumniveo-morginatum MAK in vitro显示文摘 | KOS'FENYUK I OH B J SO B J | 1999 | Plant Cell Reports1999，19，： | 1 |
| 19 | ANTIOXIDANT AND ANTIOBESITY ACTIVITIES OF SEED EXTRACT FROM CAMPBELL EARLY GRAPE AS A FUNCTIONAL INGREDIENT显示文摘 | JUNGMIN OH SO‐RA JUNG YUN‐JEONG LEE KYE WON PARK SO YEON KIM JAEJOON HAN | 2013 | Journal of Food Processing and Preservation2013，，4： | 1 |
| 20 | Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF-κB显示文摘 | Sun Mi Kim So Yong Lee Jin Suk Cho Seung Mo Son Sang Sook Choi Yeo Pyo Yun Hwan Soo Yoo Do Young Yoon Ki-Wan Oh Sang Bae Han Jin Tae Hong | 2009 | European Journal of Pharmacology2009，，1： | 1 |
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