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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 4 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 5 | Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains显示文摘 | Rodriguez E Hu Z Ou S | 2003 | J Ind Microbiol Biotechnol2003，30，8： | 1 |
| 6 | Absence of hose specificity for in vitro adhesion of probiotic lactic acid bhacteria to intestinal mucus显示文摘 | Rinhinen M Westermarck E Salminens OU wehand A C | 2003 | Vet Microbiol2003，97，12： | 1 |
| 7 | Persistence, Distribution, and Emission of Telone C35 Injected into a Florida Sandy Soil as Affected by Moisture, Organic Matter, and Plastic Film Cover显示文摘 | THOMAS J E OU L T ALLEN L H | 2004 | J Environ Sci Heal Part B2004，39，4： | 1 |
| 8 | The effect of simvastatin onchemotactic capability of SDF - 1 alpha and the promotion of boneregeneration 显示文摘 | LIU Y S OU M E LIU H | 2014 | Biomaterials2014，35，15： | 1 |
| 9 | Identification of the transcriptional targets of FOXP2,a gene linked to speech and language,in developing human brain显示文摘 | Spiteri E Konopka G Coppola G Bomar J Oldham M Ou J | | 0，，06： | 1 |
| 10 | The effectiveness of nursing education as an intervention to decrease fatigue in Turkish patients receiving chemotherapy显示文摘 | Yesilbalkan OU Karadakovan A Goker E | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 11 | Quality of life in mental y il,physical y il and healthy individuals:the valida-tion of the Greekversion of the World Health Organization Quality of Life(WHOQOL-100)questionnaire显示文摘 | Ginieri-Coccossis M Triantafil ou E Tomaras V | | 0，，08： | 1 |
| 12 | T regulatory cells in atopic dermatitis and subversion of their activity by superantigeus显示文摘 | Ou LS Goleva E Hall C | 2004 | J Allergy Clin Immunol2004，113，4： | 1 |
| 13 | The effectiveness of nursing education as an intervention to decrease fatigue in Turk- ish patients receiving chemotherapy显示文摘 | Yesilbalkan OU Karadakovan A Goker E | 2009 | Oncol Nuts Forum2009，36，4： | 1 |
| 14 | The effectiveness of nursing education as an intervention to decrease fatigue in Turkish patients receiving chemotherapy显示文摘 | Yesilbalkan OU Karadakovan A Goker E | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 15 | T regulatory cells in atopic dermatitis and subversion of their activity by superantigens 显示文摘 | OU L S GOLEVA E HALL C | 2004 | J Allergy Clin Immunol2004，113，4： | 1 |
| 16 | Tissue culture of mini-papaya显示文摘 | XIE E B OU S S YAO J | | 0，，07： | 1 |
| 17 | Electromigration and critical product in eutectlc SnPb solder lines at 100 ℃ 显示文摘 | Agarwal R Ou Shengquan E and Tu K N | 2006 | Journal of Applied Physics 1002006，，02： | 1 |
| 18 | Prevalence of rheumatic heart disease detected by echocardiographic screening 显示文摘 | Marijon E Phalla OU David S | 2007 | N Engl J Med2007，357，5： | 1 |
| 19 | Nematode, fungi, and weed control using Telone C35 and colored plastic mulches 显示文摘 | THOMAS J E OU L T ALLEN L H | 2009 | Crop Prot2009，28，4： | 1 |
| 20 | Effects of age and castration on activities of calpains and calpastatin in sheep skeletal muscle显示文摘 | H H Meyer N E Forsberg | 2004 | Jour of Ani Sci2004，5，69： | 1 |
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