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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly 显示文摘 | OTtO C M LIND B K KITZMAN D W | 1999 | N Engl J Med1999，341，1： | 1 |
| 3 | Early T-cell inactivation and apoptosis-critical events for tolerance induction after allogeneic liver transplantation显示文摘 | Meyer D Thorwarth W Otto C | 2001 | Trans- plantation Proc2001，33，12： | 1 |
| 4 | Evolution of neuroendocrine peptide systems: Gonadotropin-releasing hormone and somatostatin 显示文摘 | Lin X W Otto C J Peter R E | 1998 | Comparative Biochemistry and Physiology C1998，119，： | 1 |
| 5 | Influence of donor MHC class I antigen expression on graft survival after rat parathyroid allotransplantation 显示文摘 | Timm S Hamelmann W Otto C | 2001 | Langenbecks Arch Surg2001，386，6： | 1 |
| 6 | Circulating mesenchymal stem cells显示文摘 | ROUFOSSE C A DIREKZE N C OTTO W R | 2004 | Int J Biochem Cell Biol2004，36，： | 1 |
| 7 | Raman spectroscopy of palladium oxide on γ-alumina applicable to automotive catalysts: nondestructive, quantitative analysis, oxidation kinetics,fluorescence quenching显示文摘 | Otto K Hubbard C P Weber W H | 1992 | Applied Catalysis B: Environmental1992，1，： | 1 |
| 8 | Contributions of groundwater conditions to soil and water salinization 显示文摘 | SALAMA R B OTTO C J FITZPATRICK R W | 1999 | Hydrogeology Journal1999，，7： | 1 |
| 9 | Putative regulatory function of alloreactive Th2 cells in tolerant recipients after small bowel transplantation 显示文摘 | GASSER M OTTO C TIMMERMANN W | 2001 | Transplant Proc2001，33，： | 1 |
| 10 | Antimicrobial resistance is a major threat to public health显示文摘 | Richard W Tong H Otto C | 1998 | BMJ1998，317，： | 1 |
| 11 | P53/p21 (WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagie acid treated cancer cells 显示文摘 | Bhagavathi A N Otto G Mark C W | 1999 | Cancer Letters1999，136，： | 1 |
| 12 | Circulating mesenchymal stem cells显示文摘 | ROUFOSSE C DIREKZE N OTTO W WRIGHT N | 2004 | Int J Biochem Cell Biol2004，36，4： | 1 |
| 13 | Contributions of groundwater conditions to soil and water salinization显示文摘 | Salama R B Otto C J Fitzpatrick R W | 1999 | Hydrogeology Journal1999，7，： | 1 |
| 14 | Part 7:CPR techniques and devices:2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care显示文摘 | Cave D M Gazmuri R J Otto C W | 2010 | Circulation2010，122，183： | 1 |
| 15 | Part 8:adult advanced cardiovascular life support:2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care显示文摘 | Neumar R W Otto C W Link M S | 2010 | Circulation2010，122，183： | 1 |
| 16 | Part 8:Adult advanced cardiovascular life support=2010 A merican heart association guidelines for cardiopulmo- nary resuscitation and emergency cardiovascular care 显示文摘 | NEUMAR R W OTTO C W LINK M S | 2010 | Circulation2010，122，： | 1 |
| 17 | Bacterial peritonitis after elective endoscopic variceal ligation: a prospective study显示文摘 | Otto SL Shun-Sheng W Yang-Yuan C | 2000 | The American Journal of Gastro- enterology2000，95，1： | 1 |
| 18 | Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene显示文摘 | Bowers R R Kim J W Otto T C | 2006 | Proc Natl Acad Sci U S A2006，103，13： | 1 |
| 19 | Initiation of population-based mammography screening in Dutch municipalities and effect on breast-cancer mortality:a systematic review显示文摘 | OtTO S J FRACHEBOUD J LOOMAN C W | 2003 | Lancet2003，361，9367： | 1 |
| 20 | Evolution of neuroendocrine peptide systems:Gonadotropin -releasing hormone and sornatostatin显示文摘 | Otto C J Peter R E | 1998 | Comparative Biochemistry and Physiology C1998，119，： | 1 |
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