| 1 | Effects of astragali radix on the growth of different cancer cell lines显示文摘AIM: To investigate the inhibitory effect of a Chinese herb medicine Astragali radix (AR) on growth of different cancer cell lines.METHODS: To observe the in vitro effects of AR on tumor cell proliferation by trypan blue exclusion, MTS method and tritium thymidine incorporation assay. Apoptosis was detected by DNA ladder method.RESULTS: The inhibition rates of AR on the cell respiration of AGS, KATOⅢ, HT29, MDA231, MEL7 and MEL14 were 68.25%, 62.36%, 22.8%, 27.69%, 2.85% and 5.14%respectively at the concentration of 100 ug/ml; it inhibited AGS DNA synthesis by 87.33% at the concentration of 50ug/ml. The inhibitory effect on AGS was time-and dosedependent. AR did not induce apoptosis in AGS cells.CONCLUSION: AR specifically inhibits gastric cancer cells growth in vitro and the mechanism is mainly cytostatic but not cytotoxic or inducing apoptosis. | JiangLin Hui-FangDong JJOppenheim OMHoward | 2003 | World Journal of Gastroenterology2003，9，4： | 13 |
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