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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet . 2009 (9701)2009，，： | 4 |
| 3 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 4 | Oligomerization of nbutenes catalyzed by nickel complexes dissolved in organochloroaluminate ionic liquids显示文摘 | Olivier H Wyrvalski C N | 1997 | J Catal1997，165，： | 1 |
| 5 | Development and optimization of an adenovirus production process Amine 显示文摘 | AMINE K OLIVIER H | 2004 | J Gene Med2004，6，： | 1 |
| 6 | Overview of adverse reactions to nefopam: an analysis of the French Pharmaeovigilanee database 显示文摘 | Durrieu G Olivier P Bagheri H | 2007 | Fundam Clin Pharmacol2007，，5： | 1 |
| 7 | 显示文摘 | Chauvin Y Mussmann L Olivier H | 1995 | Angew Chem Int Ed Engl1995，34，： | 1 |
| 8 | Ionic liquids and catalysis: Recent progress from knowledge to applica- tions显示文摘 | OLIVIER B H MAGNA L MORVAN D | 2010 | Applied Catalysis A: General2010，373，12： | 1 |
| 9 | Hypersonic model testing in a shock tunnel 显示文摘 | Olivier H Gronig H Bozec A L | 1995 | AIAA Journal1995，33，2： | 1 |
| 10 | Long‐term fire history in northern Quebec: implications for the northern limit of commercial forests显示文摘 | France Oris Hugo Asselin Walter Finsinger Christelle Hély Olivier Blarquez Marie‐Eve Ferland Yves Bergeron Adam A. Ali | 2014 | J Appl Ecol2014，，3： | 1 |
| 11 | New method for analysing complete denture occlusion using the center of force concept: a clinical report显示文摘 | Olivier F Kang KH Hirayama H | 1998 | J Prosthet Dent1998，80，5： | 1 |
| 12 | The Ability of Stroke Volume Variations Obtained with Vigileo/FloTrac System to Monitor Fluid Responsiveness in Mechanically Ventilated Patients显示文摘 | Maxime Cannesson Henri Musard Olivier Desebbe Cécile Boucau Rémi Simon Roland Hénaine Jean-Jacques Lehot | 2009 | Anesthesia & Analgesia2009，，2： | 1 |
| 13 | Aggregation of 3,5-dihydroxybenzyl alcohol based dendrimers and hyperbranched polymers, and encapsulation of DR1 in such dendritic aggregates显示文摘 | Olivier B Jared B Rami H | 2004 | Inorg Chim Acta2004，357，13： | 1 |
| 14 | Carotenoid pigments of the green alga: assay on rainbow trout pigmentation in comparison with synthetic astaxanthin and canthaxanthin 显示文摘 | Georges C Olivier H | 1993 | Aqua- culture1993，112，： | 1 |
| 15 | 显示文摘 | Olivier H | 1995 | CHEMTECH1995，25，： | 1 |
| 16 | Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells显示文摘 | Héléne FD Olivier G Maria MM | 2002 | Carcinogenesis2002，23，8： | 1 |
| 17 | Gas Dynamic Principles and Experi-mental Investigations of Shock Tunnel Produced Coating显示文摘 | LUO X OLIVIER H | 2009 | Journal of Thermal Spray Technology2009，18，4： | 1 |
| 18 | Synthesis of pegylated immunonanoparticles 显示文摘 | Olivier J C Huertas R Lec H J | 2002 | Pharm Res2002，19，8： | 1 |
| 19 | Unsteady wave phenomena on a supercritical airfoil 显示文摘 | Alshabu A Olivier H | 2008 | AIAA Journal2008，46，8： | 1 |
| 20 | Inflammatory breast cancer:pilot study of intensive induction chemotherapy(FEC-HD) results in a high histologic response rate显示文摘 | CHEVALLIER B ROCHE H OLIVIER J P | 1993 | Am J Clin Oncol1993，16，： | 1 |
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