维普期刊资源整合服务平台（V6.5）

684篇 您的检索式：作者名="OLIVER C M"

选中清除导出查看参考文献查看引证文献引用追踪共35页首页上一页第1页下一页末页 /35 跳转

	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘	Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini	2007	Lancet Oncology2007，，：	2
3	An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiment显示文摘	Oliver W C Pharr G M	1992	J Mater Res1992，7，6：	2
4	Improved Technique for Determining Hardness and Elastic Modulus Using Load and Displacement Sensing Indentation Experiments 显示文摘	Oliver W C Pharr G M	1992	Journal of Materials Re- search1992，7，6：	1
5	Pressure and Velocity Distribution for Air Flow Through Fruits Packed in Shipping Containers Using Porous Media Flow Analysis 显示文摘	Talbot M T Oliver C C Gaffney P E	1990	ASHARE Transactions1990，9，：	1
6	On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘	E G Herbert G M Pharr W C Oliver B N Lucas J L Hay	2001	Thin Solid Films2001，，：	1
7	An improved technique for determining hardness and elastic-modulus using load and displacement sensing indentation experiments显示文摘	Oliver W C Pharr G M	1992	Journal of Materials Research1992，7，：	1
8	An Improved Technique for Determining Hardness and Elastic Modulus Using Load and Displacement Sensing Indentation Experiments显示文摘	Oliver W C Pharr G M	1992	Journal of Materials Research1992，7，6：	1
9	Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘	Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G	1998	Nature1998，393，：	1
10	An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments 显示文摘	OLIVER W C PHARR G M	1992	Journal of Materials Research1992，7，：	1
11	Bovine lactofemn supplementation supports immune and antioxidant status in healthy human males显示文摘	MULDER A M CONNELLAN P A OLIVER C J	2008	Nutrition Research2008，28，：	1
12	Smooth muscle cells orchestrate the endothelial cell response to flow and injury 显示文摘	Balcells M Martorell J Olive C	2010	Circulation2010，121，20：	1
13	An improved technique for deter- mining hardness and elastic modulus using load and dis- placement sensing indentation experiments 显示文摘	Oliver W C Pharr G M	1992	Journal of Materials Research1992，7，6：	1
14	Arteriovenous fistula outcomes in the era of the elderly dialysis population 显示文摘	Lok C Oliver M Su J	2005	Kidney Int2005，67，6：	1
15	The legitimacy of strategic alliances: An institutional perspective显示文摘	Dacin M T Oliver C Roy J P	2007	Strategic Management Journal2007，28，2：	1
16	Improved technique for determi ning hardness and elastic modulus using load and displace- ment sensing indentation experiments 显示文摘	Oliver W C Pharr G M	1992	Journal of Ma- terials Research1992，7，6：	1
17	Cloning,sequence comparison and in vivo expression of the gene encoding rat P-selectin显示文摘	AUCHAMPACH J A OLIVER M G ANDERSON D C	1994	Gene1994，145，：	1
18	Investigation of mixing in a rotor shape modified Taylor-vortex reactor by the means of a chemical test reaction显示文摘	Oliver R Markus M Bettina K C	2009	Chemical Engineering Science2009，64，：	1
19	An hnproved Technique for Determining Hardness and Elastic-modulus Using Load and Displacement Sensing Indentation Experiments 显示文摘	OLIVER W C PHARR G M	1992	Journal of Materials Research1992，7，6：	1
20	Improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments 显示文摘	OLIVER W C PHARR G M	1992	Journal of Materials Research1992，7，6：	1

返回顶部每页显示：

共35页首页上一页第1页下一页末页 /35 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示