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| 1 | Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat显示文摘Drought is a major environmental factor limiting wheat production worldwide,and developing drought-tolerant cultivars is a central challenge for wheat breeders globally.Therefore,it is important to identify genetic components determining drought tolerance in wheat.In this study,we identified a wheat NAC gene(TaNAC071-A)that is tightly associated with drought tolerance by a genome-wide association study.Knockdown of TaNAC071-A in wheat attenuated plant drought tolerance,whereas its overexpression significantly enhanced drought tolerance through improved water-use efficiency and increased expression of stress-responsive genes.This heightened water-saving mechanism mitigated the yield loss caused by water deficit.Further candidate gene association analysis showed that a 108-bp insertion in the promoter of TaNAC071-A alters its expression level and contributes to variation in drought tolerance among wheat accessions.This insertion contains two MYB cis-regulatory elements(CREs)that can be directly bound by the MYB transcription activator,TaMYBL1,thereby leading to increased TaNAC071-A expression and plant drought tolerance.Importantly,introgression of this 108-bp insertion allele,TaNAC071-AIn-693,into drought-sensitive cultivars could improve their drought tolerance,demonstrating that it is a valuable genetic resource for wheat breeding.Taken together,our findings highlight a major breakthrough in determining the genetic basis underlying phenotypic variation in wheat drought tolerance and showcase the potential of exploiting CRE-containing indels for improving important agronomical traits. | Hude Mao Shumin Li Bin Chen Chao Jian Fangming Mei Yifang Zhang Fangfang Li Nan Chen Tian Li Linying Du Li Ding Zhongxue Wang Xinxiu Cheng Xiaojing Wang Zhensheng Kang | 2022 | Molecular Plant2022，15，2： | 9 |
| 2 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 3 | Induction paclitaxel and carboplatin followed by concurrent chemoradiotherapy in patients with unresectable, locally advanced non-small cell lung cancinoma:report of Ffox Chase Cancer Center Study 94-001 显示文摘 | Langer C J Movsas B Hudes R | 1997 | Semin Oncol1997，24，12： | 1 |
| 4 | Temsimlimus, interferon alfa, or both for advanced renal-cell carcinoma显示文摘 | Hudes G Cardueci M Tomczak P | 2007 | N Engl J Med2007，356，： | 1 |
| 5 | Phase Ⅰ study of paclitaxel and estramustine:preliminary activity in hormone-refractory prostate cancer显示文摘 | Hudes G R Obasaju C Chapman A | 1995 | Semin Oncol1995，22，： | 1 |
| 6 | Temsirolimus,Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma 显示文摘 | Hudes G Carducci M Tomczak P | 2007 | N Engl J Med2007，356，22： | 1 |
| 7 | Targeting mTOR in renal cell carcinoma显示文摘 | Hudes GR | 2009 | Cancer2009，115，10： | 1 |
| 8 | Diet in midpuberty and sedentary activity in prepuberty predict peak bone mass 显示文摘 | Wang MC Crawford PB Hudes M | 2003 | Am J Clin Nutr2003，2，： | 1 |
| 9 | Phase Ⅱ trial of 96-hour paclitaxel plus oral estramustine phosphate in metastatic hormone-refractory prostate cancer显示文摘 | Hudes G R Nathan F Khater C | 1997 | J Clin Oncol1997，15，： | 1 |
| 10 | Temsi- rolimus, interferon alfa, or both for advanced renal-cell carcinoma显示文摘 | HUDES G CARDUCCI M TOMCZAK P | 2007 | N Engl J Med2007，356，22： | 1 |
| 11 | Phase I1 study of axitinib in sorafenib-reffactory metastatic renal cell carcinoma 显示文摘 | Rini BI Wilding G Hudes G | 2009 | J Clin Oncol2009，27，27： | 1 |
| 12 | Targeting roTOR in renal cell carcinoma显示文摘 | Hudes GR | 2009 | Can- er2009，115，10： | 1 |
| 13 | Relationship of ascorbic acid to blood lead levels显示文摘 | Hudes ES | 1999 | JAMA1999，281，： | 1 |
| 14 | Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language 显示文摘 | Rosser ZH Zerjal T Hudes ME | 2000 | Am J Hum Gene2000，67，6： | 1 |
| 15 | Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma 显示文摘 | Hudes G Carducci M Tomczak P | 2007 | NEnglJMed2007，356，22： | 1 |
| 16 | Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma显示文摘 | HUDES G CARDUCCI M TOMCZAK P | 2007 | N Engl J Med2007，356，22： | 1 |
| 17 | Antioxidant supplementation decreases lipid peroxidation biomarker F (2)-isoprostanes in plasma of smokers显示文摘 | Dietrich M Block G Hudes M | | 0，，01： | 1 |
| 18 | Targeting mTOR in renal cell carcinoma显示文摘 | HUDES G R | 2009 | Cancer2009，115，10： | 1 |
| 19 | Temsirolimus,interferon alfa,or both for advanced renal-cell carcinoma显示文摘 | Hudes G Carducci M Tomczak P | | 0，，22： | 1 |
| 20 | Temsirolimus,interfer-on alfa,or both for advanced renal-cell carcinoma 显示文摘 | Hudes G Carducci M Tomczak P | 2007 | N Engl JMed2007，356，22： | 1 |
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