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| 1 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 2 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 3 | Contrast enhancement of medical images using muhiscale decomposition 显示文摘 | Trifas Monica A Tyler John M Pianykh Oleg S | 2006 | Proceedings of SPIE2006，6057，： | 1 |
| 4 | Vector properties in photodiasociation: Quantum treatment of the correlation between the spatial anisotropy and the angular momentum polarization of the fragments 显示文摘 | Laurens D A Siebbeles Oleg S | 1994 | Journal of Chemical Physics1994，100，5： | 1 |
| 5 | Dickkopfl regulates fate de- cision and drives breast cancer stem cells to differentiation: An ex- perimentally supported mathematical model 显示文摘 | Zvia A Oleg UK Genadiy V | 2011 | PLoS One2011，6，24： | 1 |
| 6 | Nutrient and phytoplankton trends on the western Blank Sea shelf in response to cult- wral eutrophication and dimate changes显示文摘 | Oleg A Yunev Jacob | 2007 | Estuarine Coastal and shelf science2007，74，6： | 1 |
| 7 | Shushakov Inversion of surface NMR data显示文摘 | ANATOLY V LEGCHENKO OLEG A | 1998 | Geophysics1998，63，1： | 1 |
| 8 | Anomalous transparency of water-air in- terface for low-frequency sound显示文摘 | OLEG A G | 2006 | Physical Review Letters2006，97，16： | 1 |
| 9 | Shushakov Groundwater NMR in conductive water显示文摘 | OLEG A | 1996 | Geophysics1996，61，： | 1 |
| 10 | Viscosity of H2-CO2 mixtures at 500,800,and 1 100 K显示文摘 | VASILII A M OLEG A N SERGEY A N | | 0，，03： | 1 |
| 11 | A total model for monthly mean hourly direct solar radiation 显示文摘 | OLEG A ANTUN M JOSIP K | 2000 | Ecological Modelling2000，129，2： | 1 |
| 12 | Fissile materials and weapon design显示文摘 | STEVE F VALERY A F OLEG F P | 1990 | Science and Global Security1990，1，： | 1 |
| 13 | Nutrient and phytoplankton trends on the western Black Sea shelf in response to cultural eutrophication and climate changes显示文摘 | OLEG A Y JACOB C SNEJANA M | 2007 | Estuarine Coastal and Shelf Science2007，74，： | 1 |
| 14 | Organic solvent dispersions of single-walled carbon nanotubes: toward solutions of pristine nanotubes 显示文摘 | Kevin D A Richard P Oleg L | 2000 | The Journal of Physical Chemistry2000，104，38： | 1 |
| 15 | Laser diodes emitting up to 25 W at 808 nm显示文摘 | V V Bezotosnyi Vadim Yu Bondarev Oleg N Krokhin G T Mikaelyan V A Oleshchenko Valerii F Pevtsov Yurii M Popov E A Cheshev | 2009 | Quantum Electronics2009，，3： | 1 |
| 16 | Surface Coating of NiTi Shape Memory Alloys with Calcium Phosphates by Dip-coating or Plasma-spraying-biological Characterization Examined by in vitro Testing Methods显示文摘The influence of different surface coatings of NiTi shape memory alloys was examined using in vitro testing methods. Plates of superelastic nickel-titanium shape memory alloy (NiTi) were coated with calcium phosphates (hydroxyapatite) by high-temperature plasma-spraying or by dip-coating. The biocompatibility was tested in vitro by cultivation of isolated human granulocytes and whole blood cells. As substrates, pure NiTi, plasma-spray-coated NiTi and dip-coated NiTi were used. Isolated granulocytes showed an increased adhesion to both calcium phosphate-coated NiTi samples. Compared to non-coated NiTi or dip-coated NiTi, the number of dead granulocytes adherent to plasma-sprayed surfaces was significantly increased (p<0.01). Whether the differences in apoptosis of granulocytes on dip-coated vs plasma-sprayed coatings observed are due to differences in material surface morphologies has to be analyzed in further studies. Because of the cellular interactions with the coating layers, it is likely that the results obtained are not caused by the underlying NiTi but due to the coating itself. | Esenwein Stefan A Bogdanski Denise Prymak Oleg Epple Matthias Muhr Gert Kller Manfred | 2005 | Journal of Wuhan University of Technology(Materials Science)2005，20，B12： | 1 |
| 17 | Modelling daily topographic solar radiation without site-specific hourly radiation data显示文摘 | Oleg A | 1998 | Ecological Modelling1998，113，13： | 1 |
| 18 | The shaped charge jet interaction with finite thickness targets显示文摘 | Oleg V S Nicolaip K Boris A K | 2001 | Inter- national Journal of Impact Engineering2001，26，： | 1 |
| 19 | Hemostasis of massive bleeding from esophageal tumor:A case report显示文摘BACKGROUND Esophageal cancer is a common type of cancer and serious bleeding from esophageal tumors can occur in routine clinical practice.The arrest of bleeding from esophageal tumor is not a trivial task,which can sometimes require non-standard solutions.We report a case of successful hemostasis of massive bleeding from esophageal tumor performed by a novel two-balloon catheter inserted endoscopically,with a local hemostatic treatment applied.CASE SUMMARY A 36-years old male patient with advanced esophageal cancer developed bleeding from the tumor following endoscopic stenting with a self-expanding metal stent.Due to the ineffectiveness of standard approaches,after a medical conference,the patient was treated with a novel method based on the use of a two-balloon catheter creating an isolated area in esophagus and locally dispersing hemostatic polysaccharide powder inside the isolated interior.Hemostasis was successful and subsequent endoscopic examination revealed the presence of organized clot and localized defect,which was coagulated in a planned manner.CONCLUSION The authors present a new catheter-based method of hemostasis of esophageal tumor bleeding. | Aleksei A Kashintsev Dmitriy S Rusanov Mariya V Antipova Sergey V Anisimov Oleg K Granstrem NikolaiYu Kokhanenko Konstantin V Medvedev Eldar B Kutumov Anastasya A Nadeeva Vitali Proutski | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 20 | Anomaly induced effects in a magnetic field显示文摘 | Ignatios A Alexey B Oleg R | 2008 | Nuclear Physics: B2008，793，12： | 1 |
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