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| 1 | GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer显示文摘Colorectal cancer(CRC)is the third most frequently diagnosed cancer worldwide,responsible for over 880000 deaths each year.Growth/differentiation factor 15(GDF-15)is reported to be a promising diagnostic and prognostic factor in CRC.It induces pleiotropic effects in tumor cells:proliferation,sternness,invasion and metastasis.Some studies indicate that GDF-15 may stimulate angiogenesis in malignant neoplasms.However,it has not been investigated in CRC yet.The aim of our study was to determine the level of GDF-15 and the concentrations of hypoxia-inducible factor-la(HIF-1α),VEGF-A and chemokine-like receptor 1(CMKLR1)in tumor and margin specimens of CRC in relation to histological grade and TNM staging.The study comprised 33 samples of tumor and margin tissues obtained from CRC patients.To assess the concentration of GDF-15,HIF-1α,VEGF-A and CMKLR1,commercially available enzyme-linked immunosorbent assay(ELISA)kits were used.We found significantly increased levels of GDF-15 and CMKLR1 in tumor tissue compared to margin tissue and higher concentrations of HIF-1α and VEGF-A in margin tissue than in tumor tissue.The levels of GDF-15 and HIF-1α were significantly correlated with VEGF-A and CMKLR1 in margin tissue.In CRC,the increased level of GDF-15 might stimulate angiogenesis through upregulation of HIF-1α,VEGF A and CMKLR1 expression.Our study is the first one to reveal the correlation between the levels of GDF-15 and CMKLR1 in CRC.The elevated levels of HIF-1α and VEGF-A in tumor-free margin tissues suggest that noncancer cells in the tumor microenvironment are an important source of proangiogenic factors. | Sylwia Mielcarska Kamila Stopifnska Miriam Dawidowicz Agnieszka Kula Pawel Kicamer Alicja Prawdric Senkowska Ewa Nowakowska Zajde Katarzyna Walkiewicz Dariusz Waniczek Elzbieta Swietochowska | 2021 | Current Medical Science2021，41，3： | 3 |
| 2 | 天然恒牙列的动态咬合接触形式显示文摘目的:在既往研究中.从未停止过关于修复和正畸治疗中进行咬合重建时.应该建立何种形式的咬合接触的讨论。对天然恒牙列的动态咬合的流行病学调查将有助于走出这种持续讨论的困境。本研究的目的就是要通过调查研究.总结年青群体和老年群体天然牙列的特征性动态咬合接触形式,并且分析动态咬合接触形式与性别和年龄之间的相关性。材料和方法:本研究共调查了834人。所有的调查对象都具有天然牙列.并且没有修复体存在。调查对象的年龄范围是20--63岁。在调查对象进行牙诱导的侧方和前伸运动过程中,检查天然牙的动态咬合接触形式。结果:结果发现存在以下的动态咬合接触形式:双侧和单侧的尖牙保护[牙合],组牙功能[牙合].平衡[牙合]以及“其他[牙合]型”。男性和女性之间不同类型的动态咬合接触形式的出现概率相同。但是.一些咬合接触形式的出现率与年龄有相关性。随着年龄的增加.双侧和单侧尖牙保护耠的出现率出现下降趋势,而组牙功能[牙合]的出现率上升。平衡[牙合]以及“其他[牙合]型”的出现率很低.并且没有呈现与年龄相关的变化趋势。结论:双侧尖牙保护[牙合]和组牙功能[牙合]是年青患者的特征性咬合接触形式.而老年患者中组牙功能[牙合]的接触形式更加普遍。当年青患者接受修复和正畸手段的咬合重建时.尖牙保护[牙合]是一种最适合的咬合接触形式,而对于老年患者来说.组牙功能[牙合]则更加适合。需要进一步的研究来探讨[牙合]型和牙周炎、磨牙症或者颞下颌关节紊乱病之间的关系。 | Halina Panek Teresa Matthews-Brzozowska Danuta Nowakowska Beata Panek Grzegorz Bielicki Slawomir Makacewicz Malgorzata Mank iewicz 李健(译) 姜婷(审) | 2009 | 中国口腔医学继续教育杂志2009，12，6： | 2 |
| 3 | New medication treatment options for bipolar disorders 显示文摘 | KETTER TA WANG PW NOWAKOWSKA C | 2004 | Aeta Psychiat Scand Suppl2004，，422： | 1 |
| 4 | Comparison of be- havioural effects of venlafaxine and imipramine in rats显示文摘 | NOWAKOWSKA E KUS K CItODERA A | 2003 | Arzne- imittel-Forschung2003，53，4： | 1 |
| 5 | Animal models ofschizophrenia: developmental preparation in rats 显示文摘 | Ratajczak P Wozniak A Nowakowska E | 2013 | Acta Neu-robiol Exp2013，73，4： | 1 |
| 6 | Behavioural effects of fluoxetine and tianeptine, two antidepressants with op- posite action mechanisms, in rats 显示文摘 | NOWAKOWSKA E KUS K CHODERA A | 2000 | Arzneimittel-Forschung2000，50，1： | 1 |
| 7 | Genotyping of Toxoplasma gondii by multiplex PCR and peptide-based serological testing of samples from infants in Poland diagnosed with congenital toxoplasmosis显示文摘 | NOWAKOWSKA D COLON I REMINGTON JS | 2006 | J Clin Microbiol2006，44，4： | 1 |
| 8 | amino acid composition of cereal and oilseed显示文摘 | SOBKOWSKA E WARCHALEWSKI J NOWAKOWSKA K | 1973 | Nahrung1973，17，3： | 1 |
| 9 | Polymeric delivery systems for Dexamethasone 显示文摘 | Urbafiska J Karewicz A Nowakowska M | 2014 | Life Sci2014，96，1： | 1 |
| 10 | A review of anti infective and anti inflammatory chalcones 显示文摘 | Nowakowska Z | 2007 | European Journal of Medicinal Chemistry2007，42，2： | 1 |
| 11 | C4d deposition and positive posttransplant crossmatch are not necessarily markers of antibody-mediated rejection in renal allograft recipients显示文摘 | BANASIK M BORATYNSKA M NOWAKOWSKA B | 2007 | Ransplant Proc2007，39，9： | 1 |
| 12 | Consecutive exotropia as a result of esotropia surgery显示文摘 | Nowakowska O Broniarczyk-Loba A Bogorodzki B | 1999 | Klin Oczna1999，101，1： | 1 |
| 13 | New medication treatment options for bipolar disorders 显示文摘 | Ketter TA Wang PW Nowakowska C | 2004 | Acta Psychiatr Scand Suppl2004，，422： | 1 |
| 14 | Genetic alterations of WWOX in Wilms'tumor are involved in its carcinogenesis显示文摘 | Pluciennik E Nowakowska M Wujcicka W I | 2012 | Oncol Rep2012，28，4： | 1 |
| 15 | Prevalence of uterine malformations and their impact on fertility显示文摘 | Gruszka M Wilczyński J Nowakowska D | 2012 | Ginekol Pol2012，83，7： | 1 |
| 16 | Adjustable sutures surgery of intermittent divergent squint in adolescents and adults显示文摘 | Broniarezyk-Loba A Nowakowska O | 2003 | Klin Oczna2003，105，12： | 1 |
| 17 | Prevalence of uterine malforma- tions and their impact on fertility显示文摘 | Gruszka M Wilezynski J Nowakowska D | 2012 | Ginekol Pol2012，83，7： | 1 |
| 18 | Reversal of stressinduced memory changes by moclobemide:the role of neurotransmitters显示文摘 | NOWAKOWSKA E CHOLERA A KUS K | 2001 | Pol J Pharmacology2001，53，22： | 1 |
| 19 | Synthesis and spectroscopic properties of 5-tert-butyl-3-(trffluoromethyl) phthalonitrile: a novel precursor for the synthesis of phthalocyanines显示文摘 | Lapok L Gut A Nowakowska M | 2013 | Tetra- hedron Letters2013，54，33： | 1 |
| 20 | WWOX oxidoreductase-substrate and enzymatic characterization显示文摘 | Gorgul A Seta K Nowakowska M | | 0，，1： | 1 |
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