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| 1 | Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients. | Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | Consequences of bullying victimization in childhood and adolescence:A systematic review and meta-analysis显示文摘AIM To identify health and psychosocial problems associated with bullying victimization and conduct a meta-analysis summarizing the causal evidence.METHODS A systematic review was conducted using Pub Med, EMBASE, ERIC and Psyc INFO electronic databases up to 28 February 2015. The study included published longitudinal and cross-sectional articles that examined health and psychosocial consequences of bullying victimization. All meta-analyses were based on qualityeffects models. Evidence for causality was assessed using Bradford Hill criteria and the grading system developed by the World Cancer Research Fund.RESULTS Out of 317 articles assessed for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis.Statistically significant associations were observed between bullying victimization and a wide range of adverse health and psychosocial problems. The evidence was strongest for causal associations between bullying victimization and mental health problems such as depression, anxiety, poor general health and suicidal ideation and behaviours. Probable causal associations existed between bullying victimization and tobacco and illicit drug use. CONCLUSION Strong evidence exists for a causal relationship between bullying victimization, mental health problems and substance use. Evidence also exists for associations between bullying victimization and other adverse health and psychosocial problems, however, there is insufficient evidence to conclude causality. The strong evidence that bullying victimization is causative of mental illness highlights the need for schools to implement effective interventions to address bullying behaviours. | Sophie E Moore Rosana E Norman Shuichi Suetani Hannah J Thomas Peter D Sly James G Scott | 2017 | World Journal of Psychiatry2017，7，1： | 12 |
| 3 | 咽鼓管功能障碍定义、类型、临床表现及诊断的共识声明显示文摘1引言 英国NIHR卫生技术评估(HTA)计划发表的咽鼓管功能障碍治疗的系统回顾性研究指出,目前缺乏咽鼓管功能障碍统一的定义和诊断标准,推进这一领域研究进展的关键是针对咽鼓管功能障碍的诊断标准和重要临床结果达成共识。因此,2014年06月21日在荷兰阿姆斯特丹召开了由咽鼓管功能障碍领域的医学专家和科学家们参加的研讨会,旨在针对咽鼓管功能障碍的定义、临床表现、诊断及未来研究领域等方面达成共识。本文针对本次会议讨论结果总结如下。 | Schilder AG Bhutta MF Butler CC Holy C Levine LH Kvaerner KJ Norman G Pennings RJ Poe D Silvola JT Sudhoff H Lund VJ 翻曲腾飞 龚树生 | 2015 | 中国医学文摘(耳鼻咽喉科学)2015，30，6： | 5 |
| 4 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 5 | Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives显示文摘The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor(VEGF)and epidermal growth factor receptor(EGFR)signaling has improved clinical outcome of patients withmetastatic colorectal cancer(mCRC).In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC.The effects of available treatment strategies for mCRC are often temporary,with resistance and disease progression developing in most patients.Thus,new treatment strategies are urgently needed.Some GI peptides including gastrin and gastrin releasing peptide,certain growth factors such as insulin-like growth factor-ⅠandⅡand neuropeptides such as growth hormone releasing hormone(GHRH)are implicated in the growth of CRC.Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide,GHRH,and with cytotoxic peptides that can be targeted to peptide receptors on tumors,are summarized in the second part of the review. | Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally | 2014 | World Journal of Gastroenterology2014，20，20： | 3 |
| 6 | A Two source Time integrated Model for Estimating Surface Fluxes from Thermal Infrared Satellite Observations显示文摘 | Anderson M C Norman J M Diak G R | 1997 | Remote Sensing of Environment1997，60，2： | 1 |
| 7 | Health measurement scales:a practical guide to their development and use显示文摘 | Streiner D Norman G | 1994 | Oxford Medical Publication1994，，： | 1 |
| 8 | Does Problem-based Learning Work?A Meta-analysis of Evaluative Research显示文摘 | Norman G Schmidt H | 1993 | Academic Medicine1993，68，： | 1 |
| 9 | Methodological prob- lems in the retrospective computation of responsiveness to change: The lesson of Cronbach显示文摘 | Norman GR Startford P Regehr G | 1997 | J Clin Epidemiol1997，50，8： | 1 |
| 10 | Canopy structure:field methods and instrumentation 显示文摘 | NORMAN J M CAMPBELL G S | 1989 | Plant Physiological Ecology1989，91，： | 1 |
| 11 | Tissue-specific cytokine production during experiment pancreatitis: a probable mechanism for distant organ dysfunction显示文摘 | Fink G Denham W | 1997 | Dig Dis Sci1997，42，8： | 1 |
| 12 | Carbon distribution and aboveground net primary production in aspen,jack pine,and black spruce stands in Saskatchewan and Manitoba,Canada显示文摘 | Gower S T Vogel J G Norman J M | 1997 | J Geophys Res1997，102，29： | 1 |
| 13 | Does the direction of portal blood flow determine outcome with small-diameter prosthetic H-graft portacaval shunt? 显示文摘 | Rosemurgy A S Norman J G Goode S E | 1997 | Surgery1997，121，1： | 1 |
| 14 | Beyond Mind- reading: Multi-voxel Pattern, Analysis of fMRI Data显示文摘 | Norman K A Polyn A M Detre G J | 2006 | Trendsin Cognitive Science2006，10，9： | 1 |
| 15 | Automatic verifica- lion of real-lime syslems wilh discrete pobability distributions 显示文摘 | Kwiatkowska M Norman G Segala R | 2002 | Them''etical Computer Science2002，282，1： | 1 |
| 16 | Is there a common mechanism for the progTession of different types of re- nal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia 显示文摘 | FINE L G BANDYOPADHAY D NORMAN J T | 2000 | Kidney Int2000，75，： | 1 |
| 17 | Flash-lamp-pumped Ho∶ Tm∶ Cr∶ YAG and Ho∶ Tm∶ Er∶ YLF lasers:experimental results of a single,long pulse length comparison显示文摘 | Mahendra G Jani Norman P Barnes Keith E Murray | 1997 | Applied Optics1997，36，15： | 1 |
| 18 | Does the Transtheoretical Model Needan Attitude Adjustment?Integrating Attitude with Decisional Balance asPredictors of Stage of Change for Exercise显示文摘 | Jordan P J Nigg C R Norman G J | 2002 | Psychology of Sport andExercise2002，，3： | 1 |
| 19 | Active interleukin-1 receptor required for maximal progression of acute pancreatitis显示文摘 | Norman JG Fink G Franz M | 1996 | Ann Surg1996，223，： | 1 |
| 20 | Measuring change over time:assessing the usefulness of evaluative instruments显示文摘 | Guyatt G Walter S Norman G | 1987 | J Chronic Dis1987，40，2： | 1 |
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