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| 1 | Effect of TGF-131 antisense oligodeoxynucleotide on renal function in chronic renal failure rats显示文摘目的:学习是调查转变生长因素( TGF )贝它 1 反的有效性的礼品的目的在改善察觉到 oligodeoxynucleotides ( ODN )在有 导致puromycin 的长期的肾衰竭( CRF )的老鼠的败坏的肾功能 .Methods :盐,嘌呤霉素,puromycin+TGF贝它 1 反感觉 ODN 或 puromycin+scrambled ODN 予被以单方地 nephrecto-mized 老鼠。肾的血液动力学、分泌的大小在经历了外科的 procedure.Results 的使麻木的老鼠被拿:在 CRF 老鼠,在肾的血流( RBF )有显著减小,这被观察, glomerular 率( GFR ),严重蛋白尿,并且几乎6褶层在控制老鼠作为与那相比增加了钠( FE Na^+)的部分排泄(所有 P < 0.05 )。在 CRF 老鼠,有 1 反察觉到的 TGF 贝它的处理,然而并非爬的 ODN,显著地稀释了 RBF, GFR,和蛋白尿的减小并且显著地阻止了 FE Na^+ 的增加,这进一步被观察(所有 P < 0.05 ) 。另外,在 CRF 的肾的肥大组织(P < 0.05 对非肾的失败控制) 是有 TGF-1 反感觉 ODN 的显著地稀释的术后疗法(P < 0.05 ) 。焦点的部分肾小球硬化症在未经治疗、爬的对待 ODN 的 CRF 组仅仅是明显的。这研究的有趣的观察在 CRF 老鼠是那,尽管有显著 attenuating 和TGF贝它的预防效果败坏的肾的功能上的 1 反感觉 ODN ,反感觉处理没在TGF贝它的肾的表示引起任何显著变化 1 在蛋白质 level.Conclusion :一起,获得的数据建议 1 反感觉 ODN 拥有的那TGF贝它在 导致puromycin 的长期的肾衰竭的有益的效果并且在形态学的恶化和处于这个病理学的状态的损害肾的功能部分地依赖于TGF贝它的行动 1 在肾以内。 | Law Chung HIONG Kiew Lik VOON Nor Azizan ABDULLAH Munavvar A SATTAR Nazarina Abdul RAHMAN Abdul Hye KHAN4, Edward James JOHNS | 2008 | Acta Pharmacologica Sinica2008，29，4： | 7 |
| 2 | Genetic barriers in transplantation medicine显示文摘The successful of transplantation is determined by the shared human leukocyte antigens(HLAs) and ABO blood group antigens between donor and recipient. In recent years, killer cell receptor [i.e., killer cell immunoglobulinlike receptor(KIR)] and major histocompatibility complex(MHC) class I chain-related gene molecule(i.e., MICA) were also reported as important determinants of transplant compatibility. At present, several different genotyping techniques(e.g., sequence specific primer and sequence based typing) can be used to characterize blood group, HLA, MICA and KIR and loci. These molecular techniques have several advantages because they do not depend on the availability of anti-sera, cellular expression and have greater specificity and accuracy compared with the antibody-antigen based typing. Nonetheless, these molecular techniques have limited capability to capture increasing number of markers which have been demonstrated to determine donor and recipient compatibility. It is now possible to genotype multiple markers and to the extent of a complete sequencing of the human genome using next generation sequencer(NGS). This high throughput genotyping platform has been tested for HLA, and it is expected that NGS will be used to simultaneously genotype a large number of clinically relevant transplantation genes in near future. This is not far from reality due to the bioinformatics support given by the immunogenetics community and the rigorous improvement in NGS methodology. In addition, new developments in immune tolerance based therapy, donor recruitment strategies and bioengineering are expected to provide significant advances in the field of transplantation medicine. | Hisham A Edinur Siti M Manaf Nor F Che Mat | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 3 | Energy Consumption, Economic Growth and Environmental Pollutants in Indonesia 显示文摘 | Jafari Y Othman J Nor A H S M | 2012 | Journal of Policy Modeling2012，34，6： | 1 |
| 4 | Azithromycin for the secondary prevention of coronary heart disease events:The WIZARD study:a randomized controlled trial显示文摘 | O'Con nor CM Dun ne M W Pfeffer M A | | 0，，： | 1 |
| 5 | Tissue plasminogen actirator and plasminogen actirator inhibitor - 1 in stubke patients 显示文摘 | Lindgren A Lindoff C Norring 13 | 1996 | stroke1996，27，： | 1 |
| 6 | Performance of earthing systems of low resistivity soils 显示文摘 | Nor N M Haddad A Griffiths H | 2006 | IEEE Transactions on PWRD2006，21，4： | 1 |
| 7 | In vitro propagation of Acacia hybrid through alginate-encapsulated shoots and axillary buds 显示文摘 | Nor Asmah H Nor Hasnida H Noraliza A | 2012 | African Journal of Biotechnol- ogy2012，11，12： | 1 |
| 8 | Utilizing neighbours-table to improve tree routing 显示文摘 | Mostafa KA AI-Harbawi Mohd Fadlee A Rasid Nor Karnariah Noordin | 2012 | Wireless Personal Communications2012，65，： | 1 |
| 9 | Effectiveness of uncoated WC - Co and PCD inserts in end milling of titanium alloy - Ti - 6Al- 4V显示文摘 | A K M Nurul Amin Ahmad F Ismail M K Nor Khairusshima | 2007 | Journal of Materials Processing Technology2007，，： | 1 |
| 10 | Ligation of the intersphincteric fis- tula tract (LIFT) , a sphincter - saving technique for fistula - in - ano显示文摘 | Shanwani A Nor AM Amri N | 2010 | Dis Colon Rectum2010，53，1： | 1 |
| 11 | Chemical Composition and in situ Dry Matter Degradability of Stover Fractions of Five Sorghum Varieties显示文摘 | FADEL A M A ELSEED Niemat I NOR ELDAIM | 2007 | Journal of Applied Sciences Research2007，3，10： | 1 |
| 12 | Improved three-phase power-flow methods using sequence components显示文摘 | Abdel-Akher M Nor K M Rashid A H A | 2005 | IEEE Transactions on Power Systems2005，20，3： | 1 |
| 13 | Spectral analysis methods for vehicle interior vibro-acoustics identifica- tion显示文摘 | Fouladi M H Nor M J Ariffin A K | 2009 | Mechanical Systems and Signal Processing2009，23，2： | 1 |
| 14 | Bacterial pathogens and antibiotic resistance patterns in children with urinary tract infection in a Malaysian tertiary hospital显示文摘 | Noor Shafina MN Nor Azizah A Mohammad AR | 2015 | Med J Malaysia2015，70，3： | 1 |
| 15 | Cell surface molecular chaperones as endogenous modulators of the innate immune response 显示文摘 | Triantafilou M Sawyer D Nor A | 2008 | Novartis Found Symp2008，291，1： | 1 |
| 16 | Ligation of theintersphincteric fistula tract (LIFT):a sphincter-savingtechnique for fistula-in-ano显示文摘 | Shanwani A Nor AM Amri N | | 0，，01： | 1 |
| 17 | The Impact of Social Capital on Quality of Life: Evidence from Malaysia European 显示文摘 | Roslan A H Ismail R Nor Azam A R | 2010 | Journal of Eco- nomics Finance and Administrative Sciences2010，22，11： | 1 |
| 18 | An Algorithm for the Optimal Scheduling of Variable Head Hydro and Thermal Plants 显示文摘 | Halim A Rashid A Nor K M | 1993 | IEEE Trans on Power Systems1993，8，3： | 1 |
| 19 | Hydrothermal scheduling based Lagrangian relaxation approach to hydrothermal coordination显示文摘 | Salam M S Nor K M Hamdan A R | 1998 | IEEE Transactions on Power Systems1998，13，1： | 1 |
| 20 | Scheduling jobson grid computing using firefly algorithm显示文摘 | Yousif A Abdullanh A H Nor S M | 2011 | Journal of Theoretical and Applied Information Technology2011，33，2： | 1 |
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