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| 1 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 2 | Cyclostationary signa- tures in practical cognitive radio applications 显示文摘 | SUTrON P D NOLAN K E DOYLE L E | 2008 | IEEE Journal on Selected Areas in Communications2008，26，1： | 1 |
| 3 | Survival after pulmonary edema due to enterovirus 71 encephalitis显示文摘 | NOLAN N A CRAIG M E LAHRA M M | 2003 | Neurology2003，60，10： | 1 |
| 4 | Quantification of mRNA using real-time RT-PCR 显示文摘 | Nolan T Hands R E Bustin S A | 2006 | Nat Protoc2006，1，3： | 1 |
| 5 | Tools and tactics for the optical detection of mercuric ion显示文摘 | Nolan E M Lippard S J | 2008 | Chemistry Review2008，108，34： | 1 |
| 6 | Hippocampus NCAM 180 transiently increases sialylation during the acquisition and consolidation of a passive avoidance response in the adult rat显示文摘 | Doyle E Nolan PM Bell R | 1992 | J Neurosci Res1992，31，： | 1 |
| 7 | 2006, Quantification of mRNA using Real-time RT-PCR显示文摘 | Nolan T Hands R E Bustin S A | 2006 | Nature Protocols2006，1，3： | 1 |
| 8 | Measurement of labile Cu in soil using stable isotope dilution and isotope ratio analysis by ICP-MS显示文摘 | Nolan A L Ma Y B Lombi E | 2004 | Analytical and Bioanalytical Chemistry2004，380，： | 1 |
| 9 | Midrange affinity fluorescent Zn( Ⅱ ) sensors of the zinpyr family: Syntheses, characterization, and biological imaging applications显示文摘 | Nolan E M Jaworski J Racine M E | 2006 | Inorg Chem2006，45，： | 1 |
| 10 | Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses显示文摘 | Gaudieri S Nolan D McKinnon E | 2005 | Mol Immunol2005，42，4： | 1 |
| 11 | Lipid mediators in inflammatory in obesity-related glomerulopathy显示文摘 | Nolan E O'Meara YM Godson C | 2013 | Nephrol Dial Transplant2013，55，3： | 1 |
| 12 | Characterisation of the legume SERK-NIK gene superfamily including splice variants:Implications for development and defence显示文摘 | NOLAN K E KURDYUKOV S ROSE R J | 2011 | BMC Plant Biology2011，11，1： | 1 |
| 13 | Epigenetics and gene expression 显示文摘 | Gibney E R Nolan C M | 2010 | Heredity2010，105，： | 1 |
| 14 | Lipoxins attenuate re- nal fibrosis by inducing let - 7c and suppressing TGF beta R1 显示文摘 | Brennan EP Nolan KA Borgeson E | 2013 | J Am Soe NephroI2013，24，4： | 1 |
| 15 | Detection and verification of quantitative trait loci for resistance to Dothistroma needle blight in Pinus radiate显示文摘 | Devey M E Groom K A Nolan M F | 2004 | Theor Appl Genet2004，108，： | 1 |
| 16 | Near-surface moisture gradients and in situ permeation tests 显示文摘 | BASHEER P A M NOLAN E | 2001 | Construc- tion and Building Materials2001，，15： | 1 |
| 17 | Connecting the mecha-nisms of T-cell regulation:dendritic cells as the missing link显示文摘 | Cobbold SP Adams E Nolan KF | | 0，，1： | 1 |
| 18 | Demon- stration of Additive Use for Enhanced Mercury Emissions Control in Wet Desulphurization Systems 显示文摘 | P S Nolan K E Redinger G T Amrhein | 2004 | Fuel Process Techno2004，85，58： | 1 |
| 19 | Accumulation of mitochondrialDNA mutations in human immunodeficiency virus-infected patients treatedwith nucleoside-analogue reverse-transcriptase inhibitors显示文摘 | Martin AM Hammond E Nolan D | 2003 | Am J HumGenet2003，72，3： | 1 |
| 20 | Transponson mutagenesis used to study the role of complement re- sistance in the virulence of an avian Escherichia coli isolate显示文摘 | Nolan L K Wooley R E Cooper R K | 1992 | Avian Disease1992，36，2： | 1 |
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