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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Contact-damage-resistant ceramic-single-wall carbon nanotubes and ceramic/graphite composites显示文摘 | Xiaotong Wang Nitin P Padture Hidehiko Tanaka | 2004 | Nature Materials2004，，2： | 1 |
| 3 | Thermal barrier coatingsfor gas-turbine engine applications显示文摘 | Nitin P Padture Maurice Gell | 2002 | Science2002，296，： | 1 |
| 4 | A hybrid wavelet-ELM based short term price forecasting for electricity mar- kets 显示文摘 | NITIN A S BIJAYA K P | 2014 | Electrical Power and Energy Systems2014，55，： | 1 |
| 5 | Influence of prior corrosion on the high cycle fatigue behavior of microarc oxidation coated 6061-T6 Aluminum alloy显示文摘 | Nitin P W Jyothirmayi A Sundararajan G | 2011 | International Journal of Fatigue2011，33，： | 1 |
| 6 | Mechanisms of spallation of solution precursor plasma spray thermal barrier coatings 显示文摘 | Gell Maurice Xie Liangde Jordan Eric H Padture Nitin P | 2004 | Surface & Coatings Technology2004，，： | 1 |
| 7 | Flaw tolerance and crack resistance properties of alumina-aluminium titanate composites with tailored microstructure显示文摘 | Nitin P P Stephen J B Helen M C | 1993 | Journal of the American Ceramic Society1993，76，9： | 1 |
| 8 | Characterization of commercial EB-PVD TBC systems with CVD (Ni,Pt)Al bond coatings 显示文摘 | Nitin P P Maurice Gell Eric H Jordan | 2002 | Science2002，296，： | 1 |
| 9 | A review on the applications of high power, high frequency microwave source: gyrotron 显示文摘 | Nitin Kumar Udaybir Singh Singh T P | 2011 | J Fusion Energy2011，30，： | 1 |
| 10 | Thermal Barrier Coatings for Gas-turbine Engine Applications显示文摘 | PADTURE Nitin P GELL Maurice JORDAN Eric H | | 0，，： | 1 |
| 11 | Influence of fly ash on strength behavior of typical soils 显示文摘 | J Prabakar Nitin Dendorkar P K Morchhale | 2004 | Construction and Building Materials2004，18，4： | 1 |
| 12 | Urethral duplication in children : Our experience of eight cases 显示文摘 | Mane SB Abu Obaidah Nitin P | 2009 | Journal of Pe- diatric Urology2009，5，： | 1 |
| 13 | Thermal barrier coatings for bas-turbine engine applications显示文摘 | Nitin P Gell M Jordan Eh | 2002 | Science2002，296，： | 1 |
| 14 | Experimental Study of Non-Boiling Heat Transfer from a Horizontal Surface by Water Sprays 显示文摘 | Nitin K Sunil R K Subbarao P M V | 2007 | Experimental Thermal and Fluid Science2007，32，2： | 1 |
| 15 | Process intensification in Du- plex pressure swing adsorption显示文摘 | Thakur R S Nitin Kaistha Rao D P | 2011 | Computers and Chemical Engi- neering2011，35，5： | 1 |
| 16 | Exact logistic regression: theory and examples显示文摘 | Cyrus R M Nitin R P | 1995 | Stat in Med1995，15，： | 1 |
| 17 | Non-isothermal flow of a power fluid past a rectangular obstacle in channel:drag and heat transfer显示文摘 | NITIN S CHHABRA R P | 2005 | Int J of Engineering Science2005，43，： | 1 |
| 18 | Thermal Barrier Coatings for Gas-turbine Engine Applications显示文摘 | Nitin P Padture Gell M | 2002 | Science2002，12，4： | 1 |
| 19 | Effect of microstructural coarsening on Hertzian contact damage in silicon nitride显示文摘 | Hock H K Xu Wei Lanhua Nitin P Padture | 1995 | J Mater Sci1995，30，： | 1 |
| 20 | Thermal barrier coatings for gas-turbine engine applications显示文摘 | Padture Nitin P Gell Maurice Jordan Eric H | 2002 | Science2002，296，： | 1 |
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