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您的检索式：作者名="Nima Rahimi"
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| 1 | MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth显示文摘内在地混乱的蛋白质(IDP )/intrinsically 未组织的蛋白质被缺乏描绘修理或稳定的第三级的结构,并且逐渐地在信号 transduction 和 transcriptional 规定与主要角色作为蛋白质的一个重要的班被认出。在这研究,我们报导鉴定和功能的描述一以前 uncharacterized 蛋白质(UPF0258/KIAA1024 ) ,主要内在地混乱的联系 Notch2 的受体 1 (MINAR1 ) 。当 MINAR1 带一个单个 transmembrane 领域和一个短细胞质的领域时,它有不与已知的蛋白质序列分享类似的一个大细胞外的领域。Uncharacteristically, MINAR1 是一高度,有将近 70% 它的氨基酸的 IDP 定序未组织。我们证明 MINAR1 身体上与 Notch2 交往,它到 Notch2 的绑定增加它的稳定性和函数。MINAR1 广泛地包括胸的上皮的房间和血容器的 endothelial 房间在各种各样的纸巾被表示。当它在房间文化并且在塞子和 zebrafish angiogenesis 建模的老鼠 matrigel 禁止 angiogenesis, MINAR1 在 angiogenesis 起一个否定作用。而且,当 MINAR1 高度在正常的人的胸被表示时,它的表示是显著地,在先进人的乳癌的 downregulated 和它在乳癌房间的重新表示禁止了肿瘤生长。我们的学习证明 MINAR1 是否定地调整乳癌细胞的 angiogenesis 和生长的 IDP。 | Rachel Xi-Yeen Ho Rosana D. Meyer Kevin B. Chandler Esma Ersoy Michael Park Philip A. Bondzie Nima Rahimi Huihong Xu Catherine E. Costello Nader Rahimi | 2018 | Journal of Molecular Cell Biology2018，10，3： | 1 |
| 2 | Gelatin-based hydrogel functionalized with taurinemoieties for in vivo skin tissue regeneration显示文摘Functionalized hydrogels stimulate the migration and morphogenesis of endothelial cells(ECs)and are useful substrates for wound healing.The present study investigates the feasibility of covalent conjugation of taurine(Tau)on a gelatin-based hydrogel.This hydrogel is expected to maintain positive charged growth factors such as basic fibroblast growth factor(bFGF)and vascular endothelial growth factors(VEGFs)near ECs within the hydrogel microenvironment.The gelatin was conjugated with hydroxyl phenol(Ph)and Tau moieties,and in following that Ph residues were crosslinked through a horseradish peroxidase-catalyzed reaction.The migration characteristics of ECs were analyzed by scratch migration assay and microparticle-based cell migration assay.Cellular morphology and amounts of angiopoietin 1(Ang 1),bFGF,and VEGF proteins were evaluated for encapsulated cells.The potential of synthesized hydrogels in wound healing was assessed by the percentage of reduction from the original wound size and histopathological analyses of rat skin.The incorporated Tau molecules within the hydrogel remained stable through covalent bonds during incubation.During extended incubation,the gelatin-based hydrogel conjugated with Tau improved the migration distance and number of existing migrated ECs.Immobilized Tau within the gelatin-based hydrogel induced high motility of ECs,accompanied by robust cytoskeleton extension and a cell subpopulation that expressed CD44 and CD31 receptors as well as enhancement of Ang 1,bFGF,and VEGF.We found that injectable Gel-Ph-Tau effectively improves wound-healing parameters. | Farnaz Rahimi Nima Ahmadkhani Aida Goodarzi Fariba Noori Sajad Hassanzadeh Sepideh Saghati Mehdi Khanmohammadi Arash Goodarzi | 2023 | Bio-Design and Manufacturing2023，6，3： | 0 |
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